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Csnk2a1 casein kinase 2, alpha 1 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 12995, updated on 5-Nov-2019

Summary

Official Symbol
Csnk2a1provided by MGI
Official Full Name
casein kinase 2, alpha 1 polypeptideprovided by MGI
Primary source
MGI:MGI:88543
See related
Ensembl:ENSMUSG00000074698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK2; Csnk2a1-rs4
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.4), whole brain E14.5 (RPKM 26.5) and 28 other tissues See more
Orthologs

Genomic context

See Csnk2a1 in Genome Data Viewer
Location:
2; 2 G3
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152226535..152281856)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152052576..152107588)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene transcription factor 15 Neighboring gene ribosomal protein S15A, pseudogene 7 Neighboring gene TBC1 domain family, member 20 Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
NuRD complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase CK2 complex ISO
Inferred from Sequence Orthology
more info
 
protein kinase CK2 complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
casein kinase II subunit alpha
Names
CK II alpha
casein kinase II, alpha 1 polypeptide
casein kinase II, alpha 1 related sequence 4
NP_031814.2
XP_006498720.1
XP_011237574.1
XP_030102934.1
XP_030102935.1
XP_030102936.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007788.3NP_031814.2  casein kinase II subunit alpha

    See identical proteins and their annotated locations for NP_031814.2

    Status: VALIDATED

    Source sequence(s)
    AK042898, AK146032, BF018216, BY015187, CA322616
    Consensus CDS
    CCDS16879.1
    UniProtKB/Swiss-Prot
    Q60737
    Related
    ENSMUSP00000096829.3, ENSMUST00000099224.9
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    152226535..152281856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247076.1XP_030102936.1  casein kinase II subunit alpha isoform X1

  2. XM_006498657.4XP_006498720.1  casein kinase II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006498720.1

    UniProtKB/Swiss-Prot
    Q60737
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  3. XM_030247075.1XP_030102935.1  casein kinase II subunit alpha isoform X1

  4. XM_030247074.1XP_030102934.1  casein kinase II subunit alpha isoform X1

  5. XM_011239272.3XP_011237574.1  casein kinase II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011237574.1

    UniProtKB/Swiss-Prot
    Q60737
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
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