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Csnk2a1 casein kinase 2, alpha 1 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 12995, updated on 27-Nov-2024

Summary

Official Symbol
Csnk2a1provided by MGI
Official Full Name
casein kinase 2, alpha 1 polypeptideprovided by MGI
Primary source
MGI:MGI:88543
See related
Ensembl:ENSMUSG00000074698 AllianceGenome:MGI:88543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK2; CK II alpha; Csnk2a1-rs4
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.4), whole brain E14.5 (RPKM 26.5) and 28 other tissues See more
Orthologs
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Genomic context

See Csnk2a1 in Genome Data Viewer
Location:
2 G3; 2 74.83 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152068468..152123772)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152226535..152281856)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcription factor 15 Neighboring gene STARR-seq mESC enhancer starr_06046 Neighboring gene STARR-seq mESC enhancer starr_06048 Neighboring gene ribosomal protein S15A, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_06049 Neighboring gene STARR-seq mESC enhancer starr_06050 Neighboring gene STARR-positive B cell enhancer ABC_E6001 Neighboring gene STARR-seq mESC enhancer starr_06051 Neighboring gene STARR-seq mESC enhancer starr_06052 Neighboring gene STARR-positive B cell enhancer ABC_E10153 Neighboring gene TBC1 domain family, member 20 Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of aggrephagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of chromosome separation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in response to testosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of Sin3-type complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein kinase CK2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase CK2 complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
casein kinase II subunit alpha
Names
casein kinase II, alpha 1 polypeptide
casein kinase II, alpha 1 related sequence 4
NP_001403894.1
NP_001403895.1
NP_001403896.1
NP_001403897.1
NP_001403898.1
NP_001403899.1
NP_001403900.1
NP_001403901.1
NP_001403902.1
NP_001403903.1
NP_031814.2
XP_011237574.1
XP_030102934.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416965.1NP_001403894.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
  2. NM_001416966.1NP_001403895.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
  3. NM_001416967.1NP_001403896.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
  4. NM_001416968.1NP_001403897.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
  5. NM_001416969.1NP_001403898.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
  6. NM_001416970.1NP_001403899.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
  7. NM_001416971.1NP_001403900.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
  8. NM_001416972.1NP_001403901.1  casein kinase II subunit alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL831735
  9. NM_001416973.1NP_001403902.1  casein kinase II subunit alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL831735
  10. NM_001416974.1NP_001403903.1  casein kinase II subunit alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL831735
  11. NM_007788.4NP_031814.2  casein kinase II subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_031814.2

    Status: VALIDATED

    Source sequence(s)
    AL831735
    Consensus CDS
    CCDS16879.1
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
    UniProtKB/TrEMBL
    Q61177
    Related
    ENSMUSP00000096829.4, ENSMUST00000099224.10
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152068468..152123772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247074.2XP_030102934.1  casein kinase II subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
    UniProtKB/TrEMBL
    Q61177
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  2. XM_011239272.4XP_011237574.1  casein kinase II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011237574.1

    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
    UniProtKB/TrEMBL
    Q61177
    Conserved Domains (1) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2