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PXDNL peroxidasin like [ Homo sapiens (human) ]

Gene ID: 137902, updated on 2-Mar-2021

Summary

Official Symbol
PXDNLprovided by HGNC
Official Full Name
peroxidasin likeprovided by HGNC
Primary source
HGNC:HGNC:26359
See related
Ensembl:ENSG00000147485 MIM:615904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMR1; PRM1; VPO2
Expression
Biased expression in heart (RPKM 10.6), testis (RPKM 1.5) and 1 other tissue See more
Orthologs
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Genomic context

See PXDNL in Genome Data Viewer
Location:
8q11.22-q11.23
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (51319575..51809445, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (52232137..52722005, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375830 Neighboring gene uncharacterized LOC105375831 Neighboring gene BRIX1 pseudogene 1 Neighboring gene uncharacterized LOC105375833 Neighboring gene BTF3 pseudogene 1 Neighboring gene uncharacterized LOC102724330 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25471

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
peroxidasin-like protein
Names
cardiac peroxidase
cardiovascular peroxidase 2
peroxidasin homolog-like
polysomal ribonuclease 1 homolog
vascular peroxidase 2
NP_653252.4
XP_005251225.1
XP_011515760.1
XP_016868530.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144651.5NP_653252.4  peroxidasin-like protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC011128, AC012413, AC090186, AC103958, AC107374
    Consensus CDS
    CCDS47855.1
    Related
    ENSP00000348645.4, ENST00000356297.5
    Conserved Domains (7) summary
    cd09826
    Location:8511286
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00082
    Location:180232
    LRRCT; Leucine rich repeat C-terminal domain
    smart00214
    Location:14001450
    VWC; von Willebrand factor (vWF) type C domain
    sd00031
    Location:5285
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:123182
    LRR_8; Leucine rich repeat
    pfam13927
    Location:234309
    Ig_3; Immunoglobulin domain
    cl11960
    Location:528596
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    51319575..51809445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517458.2XP_011515760.1  peroxidasin-like protein isoform X1

    Conserved Domains (9) summary
    cd09826
    Location:7161151
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00082
    Location:4597
    LRRCT; Leucine rich repeat C-terminal domain
    smart00214
    Location:12651315
    VWC; von Willebrand factor (vWF) type C domain
    pfam07679
    Location:377462
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:1336
    LRR_1; leucine-rich repeat [structural motif]
    pfam03098
    Location:5921130
    An_peroxidase; Animal haem peroxidase
    pfam12799
    Location:1247
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247
    LRR_8; Leucine rich repeat
    cl11960
    Location:393461
    Ig; Immunoglobulin domain
  2. XM_017013041.1XP_016868530.1  peroxidasin-like protein isoform X1

    Conserved Domains (9) summary
    cd09826
    Location:7161151
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00082
    Location:4597
    LRRCT; Leucine rich repeat C-terminal domain
    smart00214
    Location:12651315
    VWC; von Willebrand factor (vWF) type C domain
    pfam07679
    Location:377462
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:1336
    LRR_1; leucine-rich repeat [structural motif]
    pfam03098
    Location:5921130
    An_peroxidase; Animal haem peroxidase
    pfam12799
    Location:1247
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247
    LRR_8; Leucine rich repeat
    cl11960
    Location:393461
    Ig; Immunoglobulin domain
  3. XM_005251168.3XP_005251225.1  peroxidasin-like protein isoform X2

    Conserved Domains (3) summary
    cd09826
    Location:236671
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00214
    Location:785835
    VWC; von Willebrand factor (vWF) type C domain
    pfam03098
    Location:112650
    An_peroxidase; Animal haem peroxidase
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