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CPM carboxypeptidase M [ Homo sapiens (human) ]

Gene ID: 1368, updated on 2-Nov-2024

Summary

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Official Symbol
CPMprovided by HGNC
Official Full Name
carboxypeptidase Mprovided by HGNC
Primary source
HGNC:HGNC:2311
See related
Ensembl:ENSG00000135678 MIM:114860; AllianceGenome:HGNC:2311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 56.0), lung (RPKM 21.3) and 19 other tissues See more
Orthologs
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Genomic context

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See CPM in Genome Data Viewer
Location:
12q15
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (68842197..68963469, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (68821776..68943048, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69235977..69357249, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MAPK activated protein kinase 2 pseudogene Neighboring gene solute carrier family 35 member E3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:69181025-69181579 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:69181580-69182133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4648 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:69202246-69203445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:69225023-69225696 Neighboring gene SZRD1 pseudogene 1 Neighboring gene MDM2 proto-oncogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4650 Neighboring gene RNA, U7 small nuclear 4 pseudogene Neighboring gene PRELI domain containing 2 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:69401223-69401916 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:69417938-69419137 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:69420279-69420508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:69436381-69436882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:69436883-69437382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:69447351-69447948 Neighboring gene transcript overexpressed in dedifferentiated liposarcoma Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:69461643-69462842 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:69509413-69510201 Neighboring gene MPRA-validated peak1782 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:69633505-69634085 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:69634086-69634665 Neighboring gene Sharpr-MPRA regulatory region 12312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:69639551-69640050 Neighboring gene MPRA-validated peak1783 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6648 Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene microRNA 1279

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Carboxypeptidase M in brain and peripheral nerves. Nagae A, et al. J Neurochem, 1992 Dec. PMID 1431901
  2. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. Reverter D, et al. J Mol Biol, 2004 Apr 23. PMID 15066430
  3. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. Tan F, et al. Biochem J, 2003 Mar 1. PMID 12457462, Free PMC Article
  4. Carboxypeptidase M modulates BMSCs osteogenesis-adipogenesis via the MAPK/ERK pathway: An integrated single-cell and bulk transcriptomic study. Liao Z, et al. FASEB J, 2024 May 15. PMID 38713087
  5. Molecular structure and alternative splicing of the human carboxypeptidase M gene. Pessoa LG, et al. Biol Chem, 2002 Feb. PMID 11934264

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Carboxypeptidase M modulates BMSCs osteogenesis-adipogenesis via the MAPK/ERK pathway: An integrated single-cell and bulk transcriptomic study.
    Title: Carboxypeptidase M modulates BMSCs osteogenesis-adipogenesis via the MAPK/ERK pathway: An integrated single-cell and bulk transcriptomic study.
  2. Our work shows for the first time that the interaction between CPM and kinin B1 receptor alters not only B1R pharmacology, but also modulates enzyme expression and activity.
    Title: Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.
  3. The rs12812500 variant of the CPM gene may increase silicosis susceptibility by affecting the expression of CPM, which may contribute to silicosis susceptibility with biological plausibility.
    Title: Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.
  4. Low CPM expression is associated with colorectal cancer.
    Title: MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway.
  5. CPM binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling.
    Title: Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.
  6. Carboxypeptidase M expression is lost in human renal cell carcinoma tumor cells, whereas it is abundant in tumor-associated foam cells and neovasculature.
    Title: Mapping of carboxypeptidase m in normal human kidney and renal cell carcinoma: expression in tumor-associated neovasculature and macrophages.
  7. novel marker and cellular player in lipid uptake and/or metabolism of activated macrophages by promoting foam cell formation
    Title: Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.
  8. CPM and B1Rs on cell membranes form a critical complex that potentiates B1R signaling.
    Title: Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling.
  9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.
  10. CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors.
    Title: Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci of silica related pneumoconiosis in Han Chinese.
EBI GWAS Catalog
Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of carboxypeptidase M (CPM) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxypeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxypeptidase M
Names
renal carboxypeptidase
urinary carboxypeptidase B
NP_001005502.1
NP_001400316.1
NP_001400317.1
NP_001400318.1
NP_001400319.1
NP_001400320.1
NP_001400321.1
NP_001400322.1
NP_001400323.1
NP_001400324.1
NP_001400325.1
NP_001400326.1
NP_001400327.1
NP_001400328.1
NP_001400329.1
NP_001400330.1
NP_001400331.1
NP_001400332.1
NP_001400333.1
NP_001865.1
NP_938079.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005502.3 → NP_001005502.1  carboxypeptidase M isoform b precursor

    See identical proteins and their annotated locations for NP_001005502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variants 1, 2, and 5-8. Variants 1-3 and 5-8 all encode the same isoform (b).
    Source sequence(s)
    AC025423
    Consensus CDS
    CCDS8987.1
    UniProtKB/Swiss-Prot
    B2R800, P14384, Q9H2K9
    Conserved Domains (2) summary
    cd03866
    Location:18 → 310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
    cd11308
    Location:314 → 394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  2. NM_001413387.1 → NP_001400316.1  carboxypeptidase M isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423

  3. NM_001413388.1 → NP_001400317.1  carboxypeptidase M isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423, AC133749
    UniProtKB/Swiss-Prot
    B2R800, P14384, Q9H2K9

  4. NM_001413389.1 → NP_001400318.1  carboxypeptidase M isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423
    UniProtKB/Swiss-Prot
    B2R800, P14384, Q9H2K9

  5. NM_001413390.1 → NP_001400319.1  carboxypeptidase M isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423
    UniProtKB/Swiss-Prot
    B2R800, P14384, Q9H2K9
    Related
    ENSP00000339157.3, ENST00000338356.7

  6. NM_001413391.1 → NP_001400320.1  carboxypeptidase M isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423
    UniProtKB/Swiss-Prot
    B2R800, P14384, Q9H2K9

  7. NM_001413392.1 → NP_001400321.1  carboxypeptidase M isoform c

    Status: REVIEWED

    Source sequence(s)
    AC025423

  8. NM_001413393.1 → NP_001400322.1  carboxypeptidase M isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423, AC133749

  9. NM_001413394.1 → NP_001400323.1  carboxypeptidase M isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423

  10. NM_001413395.1 → NP_001400324.1  carboxypeptidase M isoform e

    Status: REVIEWED

    Source sequence(s)
    AC025423

  11. NM_001413396.1 → NP_001400325.1  carboxypeptidase M isoform e

    Status: REVIEWED

    Source sequence(s)
    AC025423

  12. NM_001413397.1 → NP_001400326.1  carboxypeptidase M isoform f

    Status: REVIEWED

    Source sequence(s)
    AC025423, AC133749

  13. NM_001413398.1 → NP_001400327.1  carboxypeptidase M isoform f

    Status: REVIEWED

    Source sequence(s)
    AC025423, AC133749

  14. NM_001413399.1 → NP_001400328.1  carboxypeptidase M isoform f

    Status: REVIEWED

    Source sequence(s)
    AC025423

  15. NM_001413400.1 → NP_001400329.1  carboxypeptidase M isoform f

    Status: REVIEWED

    Source sequence(s)
    AC025423

  16. NM_001413401.1 → NP_001400330.1  carboxypeptidase M isoform f

    Status: REVIEWED

    Source sequence(s)
    AC025423

  17. NM_001413402.1 → NP_001400331.1  carboxypeptidase M isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC025423

  18. NM_001413403.1 → NP_001400332.1  carboxypeptidase M isoform h

    Status: REVIEWED

    Source sequence(s)
    AC025423

  19. NM_001413404.1 → NP_001400333.1  carboxypeptidase M isoform h

    Status: REVIEWED

    Source sequence(s)
    AC025423

  20. NM_001874.5 → NP_001865.1  carboxypeptidase M isoform b precursor

    See identical proteins and their annotated locations for NP_001865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variants 2, 3, and 5-8. Variants 1-3 and 5-8 all encode the same isoform (b).
    Source sequence(s)
    AC025423, AC133749
    Consensus CDS
    CCDS8987.1
    UniProtKB/Swiss-Prot
    B2R800, P14384, Q9H2K9
    Related
    ENSP00000447255.1, ENST00000546373.5
    Conserved Domains (2) summary
    cd03866
    Location:18 → 310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
    cd11308
    Location:314 → 394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  21. NM_198320.5 → NP_938079.1  carboxypeptidase M isoform b precursor

    See identical proteins and their annotated locations for NP_938079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variants 1, 3, and 5-8. Variants 1-3 and 5-8 all encode the same isoform (b).
    Source sequence(s)
    AC025423
    Consensus CDS
    CCDS8987.1
    UniProtKB/Swiss-Prot
    B2R800, P14384, Q9H2K9
    Related
    ENSP00000448517.1, ENST00000551568.6
    Conserved Domains (2) summary
    cd03866
    Location:18 → 310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
    cd11308
    Location:314 → 394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RNA

  1. NR_182142.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025423

  2. NR_182143.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025423

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    68842197..68963469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001748580.3 RNA Sequence

  2. XR_001748577.3 RNA Sequence

  3. XR_001748578.3 RNA Sequence

  4. XR_007063051.1 RNA Sequence

  5. XR_007063050.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    68821776..68943048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008488534.1 RNA Sequence

  2. XR_008488532.1 RNA Sequence

  3. XR_008488533.1 RNA Sequence

  4. XR_008488536.1 RNA Sequence

  5. XR_008488535.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14384.2 GenPept UniProtKB/Swiss-Prot:P14384

Gene LinkOut

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