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CPM carboxypeptidase M [ Homo sapiens (human) ]

Gene ID: 1368, updated on 7-Dec-2018

Summary

Official Symbol
CPMprovided by HGNC
Official Full Name
carboxypeptidase Mprovided by HGNC
Primary source
HGNC:HGNC:2311
See related
Ensembl:ENSG00000135678 MIM:114860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 56.0), lung (RPKM 21.3) and 19 other tissues See more
Orthologs

Genomic context

See CPM in Genome Data Viewer
Location:
12q15
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (68842193..68963240, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69244955..69357020, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369820 Neighboring gene SUZ RNA binding domain containing 1 pseudogene Neighboring gene MDM2 proto-oncogene Neighboring gene RNA, U7 small nuclear 4 pseudogene Neighboring gene PRELI domain containing 2 pseudogene 1 Neighboring gene uncharacterized LOC107984471 Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene microRNA 1279

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci of silica related pneumoconiosis in Han Chinese.
NHGRI GWA Catalog
Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of carboxypeptidase M (CPM) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxypeptidase activity TAS
Traceable Author Statement
more info
PubMed 
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface HDA PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carboxypeptidase M
Names
renal carboxypeptidase
urinary carboxypeptidase B
NP_001005502.1
NP_001865.1
NP_938079.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005502.2NP_001005502.1  carboxypeptidase M precursor

    See identical proteins and their annotated locations for NP_001005502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variants 1 and 2. All three variants encode the same protein.
    Source sequence(s)
    AC025423, AF368463, BC016943, BC022276, BQ431065, DA831499, DA833423, DB006895
    Consensus CDS
    CCDS8987.1
    UniProtKB/Swiss-Prot
    P14384
    Related
    ENSP00000339157.3, ENST00000338356.7
    Conserved Domains (2) summary
    cd03866
    Location:18310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
    cd11308
    Location:314394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
  2. NM_001874.4NP_001865.1  carboxypeptidase M precursor

    See identical proteins and their annotated locations for NP_001865.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variants 2 and 3. All three variants encode the same protein.
    Source sequence(s)
    AC025423, AF368463, BC016943, BC022276, BQ431065, DA831499, DA833423, J04970
    Consensus CDS
    CCDS8987.1
    UniProtKB/Swiss-Prot
    P14384
    Related
    ENSP00000447255.1, ENST00000546373.5
    Conserved Domains (2) summary
    cd03866
    Location:18310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
    cd11308
    Location:314394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
  3. NM_198320.4NP_938079.1  carboxypeptidase M precursor

    See identical proteins and their annotated locations for NP_938079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variants 1 and 3. All three variants encode the same protein.
    Source sequence(s)
    AC025423, AF368463, BC016943, BC022276, BQ431065, DA205368, DA831499, DA833423, J04970
    Consensus CDS
    CCDS8987.1
    UniProtKB/Swiss-Prot
    P14384
    Related
    ENSP00000448517.1, ENST00000551568.5
    Conserved Domains (2) summary
    cd03866
    Location:18310
    M14_CPM; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase M subgroup
    cd11308
    Location:314394
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    68842193..68963240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001748579.2 RNA Sequence

  2. XR_001748581.2 RNA Sequence

  3. XR_001748584.2 RNA Sequence

  4. XR_001748582.2 RNA Sequence

  5. XR_001748580.2 RNA Sequence

  6. XR_001748583.2 RNA Sequence

  7. XR_001748577.2 RNA Sequence

  8. XR_001748578.2 RNA Sequence

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