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CORO1A coronin 1A [ Homo sapiens (human) ]

Gene ID: 11151, updated on 19-Nov-2019

Summary

Official Symbol
CORO1Aprovided by HGNC
Official Full Name
coronin 1Aprovided by HGNC
Primary source
HGNC:HGNC:2252
See related
Ensembl:ENSG00000102879 MIM:605000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Expression
Biased expression in lymph node (RPKM 216.7), bone marrow (RPKM 179.6) and 10 other tissues See more
Orthologs

Genomic context

See CORO1A in Genome Data Viewer
Location:
16p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30183410..30189076)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30194731..30200397)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928595 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene mitogen-activated protein kinase 3 Neighboring gene uncharacterized LOC107984834 Neighboring gene SLX1A-SULT1A3 readthrough (NMD candidate) Neighboring gene bolA family member 2B Neighboring gene SLX1 homolog A, structure-specific endonuclease subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41407, MGC117380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin monomer binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeletal protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
myosin heavy chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
early endosome to recycling endosome transport IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
NOT immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vesicle fusion IEA
Inferred from Electronic Annotation
more info
 
nerve growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagolysosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
uropod organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coronin-1A
Names
clipin-A
coronin, actin binding protein, 1A
coronin-1
coronin-like protein A
coronin-like protein p57
tryptophan aspartate-containing coat protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023415.1 RefSeqGene

    Range
    4806..10472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_195

mRNA and Protein(s)

  1. NM_001193333.2NP_001180262.1  coronin-1A

    See identical proteins and their annotated locations for NP_001180262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK314714, BC110374, DA256300, DC408372, U34690
    Consensus CDS
    CCDS10673.1
    UniProtKB/Swiss-Prot
    P31146
    UniProtKB/TrEMBL
    A0A024R611
    Related
    ENSP00000455552.1, ENST00000570045.5
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:9461
    WD40_4; Type of WD40 repeat
  2. NM_007074.3NP_009005.1  coronin-1A

    See identical proteins and their annotated locations for NP_009005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC110374, DA256300, DC408372, U34690
    Consensus CDS
    CCDS10673.1
    UniProtKB/Swiss-Prot
    P31146
    UniProtKB/TrEMBL
    A0A024R611
    Related
    ENSP00000219150.5
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:9461
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30183410..30189076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022885.2XP_016878374.1  coronin-1A isoform X1

  2. XM_011545714.2XP_011544016.1  coronin-1A isoform X2

    See identical proteins and their annotated locations for XP_011544016.1

    UniProtKB/Swiss-Prot
    P31146
    UniProtKB/TrEMBL
    A0A024R611
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:9461
    WD40_4; Type of WD40 repeat
  3. XM_017022886.1XP_016878375.1  coronin-1A isoform X1

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