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CORO1A coronin 1A [ Homo sapiens (human) ]

Gene ID: 11151, updated on 5-Sep-2021

Summary

Official Symbol
CORO1Aprovided by HGNC
Official Full Name
coronin 1Aprovided by HGNC
Primary source
HGNC:HGNC:2252
See related
Ensembl:ENSG00000102879 MIM:605000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Expression
Biased expression in lymph node (RPKM 216.7), bone marrow (RPKM 179.6) and 10 other tissues See more
Orthologs
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Genomic context

See CORO1A in Genome Data Viewer
Location:
16p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30183602..30189076)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30194923..30200397)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene YPEL3 divergent transcript Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene mitogen-activated protein kinase 3 Neighboring gene CORO1A antisense RNA 1 Neighboring gene SLX1A-SULT1A3 readthrough (NMD candidate) Neighboring gene bolA family member 2B Neighboring gene SLX1 homolog A, structure-specific endonuclease subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41407, MGC117380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables actin monomer binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytoskeletal protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myosin heavy chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
involved_in early endosome to recycling endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vesicle fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in nerve growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagolysosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
involved_in uropod organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coronin-1A
Names
clipin-A
coronin, actin binding protein, 1A
coronin-1
coronin-like protein A
coronin-like protein p57
tryptophan aspartate-containing coat protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023415.1 RefSeqGene

    Range
    4806..10472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_195

mRNA and Protein(s)

  1. NM_001193333.3NP_001180262.1  coronin-1A

    See identical proteins and their annotated locations for NP_001180262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK314714, BC110374, DA256300, U34690
    Consensus CDS
    CCDS10673.1
    UniProtKB/Swiss-Prot
    P31146
    UniProtKB/TrEMBL
    A0A024R611
    Related
    ENSP00000455552.1, ENST00000570045.5
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9461
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_007074.4NP_009005.1  coronin-1A

    See identical proteins and their annotated locations for NP_009005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC110374, U34690
    Consensus CDS
    CCDS10673.1
    UniProtKB/Swiss-Prot
    P31146
    UniProtKB/TrEMBL
    A0A024R611
    Related
    ENSP00000219150.6, ENST00000219150.10
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9461
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30183602..30189076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022885.2XP_016878374.1  coronin-1A isoform X1

  2. XM_011545714.2XP_011544016.1  coronin-1A isoform X2

    See identical proteins and their annotated locations for XP_011544016.1

    UniProtKB/Swiss-Prot
    P31146
    UniProtKB/TrEMBL
    A0A024R611
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9461
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017022886.1XP_016878375.1  coronin-1A isoform X1

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