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Vitam Horm. 2017;104:113-131. doi: 10.1016/bs.vh.2016.10.002. Epub 2016 Nov 29.

Emergent Role of Coronin-1a in Neuronal Signaling.

Author information

1
University of Virginia, Charlottesville, VA, United States.
2
University of Virginia, Charlottesville, VA, United States. Electronic address: deppmann@virginia.edu.

Abstract

The Coronin family of proteins were first noted for their role in pathogen-host interactions and for modulating actin dynamics. Recently, however, Coronins have been found in a greater variety of cell types, and novel roles for the Coronins within the nervous system have been discovered. In the immune system, Coronin-1a enables Mycobacterium tuberculosis to evade lysosomal destruction. This activity appears to be analogous to protection of the NGF-TrkA signaling endosome during sympathetic nervous system development that is required for survival signaling. Similarly, others have implicated Coronin-1a in GPCR signaling during the formation of excitatory connections in the central nervous system. Its role in multiple signaling pathways suggests that it may influence cross talk between key pathways (TrkA, GPCRs) during neurodevelopment. Here, we review the role of Coronin-1a in neural development and function.

KEYWORDS:

Coro1a; Coronin; NGF; Nerve growth factor; Neurodevelopment; Neurotrophins; Receptor tyrosine kinase; Sympathetic nervous system; TrkA

PMID:
28215292
PMCID:
PMC5667946
DOI:
10.1016/bs.vh.2016.10.002
[Indexed for MEDLINE]
Free PMC Article

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