Coro1a coronin, actin binding protein 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coro1aprovided by MGI
Official Full Name: coronin, actin binding protein 1Aprovided by MGI
Primary source: MGI:MGI:1345961
See related: Ensembl:ENSMUSG00000030707 AllianceGenome:MGI:1345961
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p57; Lmb3; TACO; Clabp
Summary: This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression: Biased expression in thymus adult (RPKM 522.1), spleen adult (RPKM 445.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 69.25 cM; 7 F3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126298946..126303988, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126699774..126704816, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles.
Title: Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles.
Coronin 1 Is Required for Integrin beta2 Translocation in Platelets.
Title: Coronin 1 Is Required for Integrin β2 Translocation in Platelets.
this study shows that disruption of Coronin 1 signaling in T cells promotes allograft tolerance while maintaining anti-pathogen immunity
Title: Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity.
PtpA from Staphylococcus aureus contributes to virulence and interacts with coronin-1A during infection.
Title: PtpA, a secreted tyrosine phosphatase from Staphylococcus aureus, contributes to virulence and interacts with coronin-1A during infection.
Coro1A has a role in platelet biology with impact on spreading, aggregation and thrombosis
Title: The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis.
our findings indicate that coronin 1A is a pivotal component that regulates lysosomal fusion and the secretion pathway in osteoclast-lineage cells and may provide a novel therapeutic target for bone diseases.
Title: Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K.
these data suggest that coronin 1 is dispensable for mouse NK cell homeostasis and function.
Title: Role for coronin 1 in mouse NK cell function.
Results suggest the existence of a hitherto unrecognized coronin 1-dependent decision switch early during life that is responsible for peripheral naive T cell survival and homeostasis.
Title: A Coronin 1-Dependent Decision Switch in Juvenile Mice Determines the Population of the Peripheral Naive T Cell Compartment.
Coro1A represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
Title: Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity.
the phenotype of T cell-specific Coronin 1a deletion resembles the phenotype observed with conventional (whole body) Coronin 1a knock-out mice. In summary, our findings provide formal proof of the predominant T cell-intrinsic role of Coronin 1A.
Title: Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Associated conditions

Description	Tests
lupus in MRL and B6 F2 cross, QTL 3 GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (5) 1 citation
QTL (2) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit211 (e-PCR), detects polymorphism
- UniSTS:131105

D7Nds1 (e-PCR), detects polymorphism
- UniSTS:142691

Coro1a (e-PCR), detects polymorphism
- UniSTS:499081

D7Mit82 (e-PCR), detects polymorphism
- UniSTS:116717

Homology

Homologs of the Coro1a gene: The Coro1a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 230 organisms have orthologs with human gene Coro1a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin heavy chain binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-4	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within early endosome to recycling endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin nucleation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nerve growth factor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagolysosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of actin polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uropod organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium tip	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coronin-1A

Names: clipin-A; coronin 1; coronin-like actin binding protein; coronin-like protein A; coronin-like protein p57; tryptophan aspartate-containing coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301374.2 → NP_001288303.1 coronin-1A

See identical proteins and their annotated locations for NP_001288303.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1-4 all encode the same protein.

Source sequence(s)

AC124505

Consensus CDS

CCDS21840.1

UniProtKB/Swiss-Prot

O89053, Q9R288

UniProtKB/TrEMBL

Q3U1N0

Related

ENSMUSP00000101972.2, ENSMUST00000106364.8

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001412247.1 → NP_001399176.1 coronin-1A

Status: REVIEWED

Source sequence(s)

AC124505

UniProtKB/Swiss-Prot

Q9R288

UniProtKB/TrEMBL

Q3U1N0
NM_001412248.1 → NP_001399177.1 coronin-1A

Status: REVIEWED

Source sequence(s)

AC124505

UniProtKB/Swiss-Prot

Q9R288

UniProtKB/TrEMBL

Q3U1N0
NM_009898.4 → NP_034028.1 coronin-1A

See identical proteins and their annotated locations for NP_034028.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AC124505

Consensus CDS

CCDS21840.1

UniProtKB/Swiss-Prot

O89053, Q9R288

UniProtKB/TrEMBL

Q3U1N0

Related

ENSMUSP00000032949.8, ENSMUST00000032949.14

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

NR_178084.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124505

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

126298946..126303988 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507284.5 → XP_006507347.1 coronin-1A isoform X1

UniProtKB/Swiss-Prot

O89053

UniProtKB/TrEMBL

Q3U1N0

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006507285.4 → XP_006507348.1 coronin-1A isoform X1

See identical proteins and their annotated locations for XP_006507348.1

UniProtKB/Swiss-Prot

O89053, Q9R288

UniProtKB/TrEMBL

Q3U1N0

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...