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Immunity. 2008 Jan;28(1):40-51. doi: 10.1016/j.immuni.2007.11.023.

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.

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1
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases.

PMID:
18199416
PMCID:
PMC2274909
DOI:
10.1016/j.immuni.2007.11.023
[Indexed for MEDLINE]
Free PMC Article
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