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Mybpc1 myosin binding protein C, slow-type [ Mus musculus (house mouse) ]

Gene ID: 109272, updated on 5-Mar-2024

Summary

Official Symbol
Mybpc1provided by MGI
Official Full Name
myosin binding protein C, slow-typeprovided by MGI
Primary source
MGI:MGI:1336213
See related
Ensembl:ENSMUSG00000020061 AllianceGenome:MGI:1336213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8030451F13Rik
Summary
Predicted to enable myosin binding activity. Acts upstream of or within muscle contraction. Predicted to be located in cytoskeleton. Is expressed in several structures, including brain; eyelid epithelium; hindlimb; reproductive system; and skeletal musculature. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1B and lethal congenital contracture syndrome 4. Orthologous to human MYBPC1 (myosin binding protein C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 9.6), mammary gland adult (RPKM 6.9) and 11 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Mybpc1 in Genome Data Viewer
Location:
10 C1; 10 43.99 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88354141..88441051, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88518279..88605229, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11453 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Neighboring gene STARR-positive B cell enhancer ABC_E5162 Neighboring gene STARR-positive B cell enhancer mm9_chr10:87872706-87873007 Neighboring gene STARR-positive B cell enhancer ABC_E2333 Neighboring gene STARR-positive B cell enhancer ABC_E3906 Neighboring gene synaptonemal complex protein 3 Neighboring gene choline phosphotransferase 1 Neighboring gene STARR-seq mESC enhancer starr_27496 Neighboring gene STARR-seq mESC enhancer starr_27498 Neighboring gene STARR-positive B cell enhancer ABC_E6897 Neighboring gene STARR-seq mESC enhancer starr_27500 Neighboring gene STARR-seq mESC enhancer starr_27501 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 48106

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables myosin binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within muscle contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myosin-binding protein C, slow-type
Names
MyBP-C slow
Slow-type C-protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252372.1NP_001239301.1  myosin-binding protein C, slow-type isoform 1

    See identical proteins and their annotated locations for NP_001239301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK132188, BB669565, BC062158, BY135230
    Consensus CDS
    CCDS56739.1
    UniProtKB/TrEMBL
    A0A571BEN1, D3YU50
    Related
    ENSMUSP00000112699.2, ENSMUST00000119185.8
    Conserved Domains (8) summary
    cd00096
    Location:10331098
    Ig; Immunoglobulin domain
    cd05894
    Location:518603
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:521603
    IG_like; Immunoglobulin like
    cd00063
    Location:607696
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10161105
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:51135
    ig; Immunoglobulin domain
    pfam03755
    Location:136235
    YicC_N; YicC-like family, N-terminal region
    cl11960
    Location:826883
    Ig; Immunoglobulin domain
  2. NM_175418.5NP_780627.2  myosin-binding protein C, slow-type isoform 2

    See identical proteins and their annotated locations for NP_780627.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BB669565, BC062158, BY135230
    Consensus CDS
    CCDS48666.1
    UniProtKB/TrEMBL
    A0A571BEN1, Q6P6L5
    Related
    ENSMUSP00000112615.2, ENSMUST00000121629.8
    Conserved Domains (8) summary
    cd00096
    Location:10471112
    Ig; Immunoglobulin domain
    cd05894
    Location:532617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:535617
    IG_like; Immunoglobulin like
    cd00063
    Location:621710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10301119
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:65149
    ig; Immunoglobulin domain
    pfam03755
    Location:150249
    YicC_N; YicC-like family, N-terminal region
    cl11960
    Location:840897
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    88354141..88441051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513045.5XP_006513108.1  myosin-binding protein C, slow-type isoform X1

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:557642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:90185
    IG_like; Immunoglobulin like
    cd00063
    Location:646735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10731162
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:235268
    THB; Tri-helix bundle domain
    cl11960
    Location:882940
    Ig; Immunoglobulin domain
  2. XM_006513047.5XP_006513110.1  myosin-binding protein C, slow-type isoform X2

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:557642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:90185
    IG_like; Immunoglobulin like
    cd00063
    Location:646735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10731162
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:235268
    THB; Tri-helix bundle domain
    cl11960
    Location:882940
    Ig; Immunoglobulin domain
  3. XM_006513053.5XP_006513116.1  myosin-binding protein C, slow-type isoform X8

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:531616
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:64159
    IG_like; Immunoglobulin like
    cd00063
    Location:620709
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10471136
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:209242
    THB; Tri-helix bundle domain
    cl11960
    Location:856914
    Ig; Immunoglobulin domain
  4. XM_006513049.5XP_006513112.1  myosin-binding protein C, slow-type isoform X4

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:543628
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:76171
    IG_like; Immunoglobulin like
    cd00063
    Location:632721
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10591148
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:221254
    THB; Tri-helix bundle domain
    cl11960
    Location:868926
    Ig; Immunoglobulin domain
  5. XM_006513052.5XP_006513115.1  myosin-binding protein C, slow-type isoform X7

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:532617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:65160
    IG_like; Immunoglobulin like
    cd00063
    Location:621710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10481137
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:210243
    THB; Tri-helix bundle domain
    cl11960
    Location:857915
    Ig; Immunoglobulin domain
  6. XM_036155497.1XP_036011390.1  myosin-binding protein C, slow-type isoform X12

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd00063
    Location:621710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10481137
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:210243
    THB; Tri-helix bundle domain
    cd00096
    Location:6164
    Ig; Ig strand A [structural motif]
    cd05894
    Location:532617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    cl11960
    Location:60160
    Ig; Immunoglobulin domain
  7. XM_006513046.5XP_006513109.1  myosin-binding protein C, slow-type isoform X3

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:545630
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:78173
    IG_like; Immunoglobulin like
    cd00063
    Location:634723
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10611150
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:223256
    THB; Tri-helix bundle domain
    cl11960
    Location:870928
    Ig; Immunoglobulin domain
  8. XM_006513054.5XP_006513117.1  myosin-binding protein C, slow-type isoform X9

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:557642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00409
    Location:90185
    IG; Immunoglobulin
    cd00063
    Location:646735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10731162
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:235268
    THB; Tri-helix bundle domain
    cl11960
    Location:882940
    Ig; Immunoglobulin domain
  9. XM_006513057.5XP_006513120.1  myosin-binding protein C, slow-type isoform X13

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:518603
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:51146
    IG_like; Immunoglobulin like
    cd00063
    Location:607696
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10341123
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:196229
    THB; Tri-helix bundle domain
    cl11960
    Location:843901
    Ig; Immunoglobulin domain
  10. XM_006513050.5XP_006513113.1  myosin-binding protein C, slow-type isoform X6

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:557642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:90185
    IG_like; Immunoglobulin like
    cd00063
    Location:646735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10551144
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:235268
    THB; Tri-helix bundle domain
    cl11960
    Location:864922
    Ig; Immunoglobulin domain
  11. XM_036155496.1XP_036011389.1  myosin-binding protein C, slow-type isoform X10

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd00063
    Location:646735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10551144
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:235268
    THB; Tri-helix bundle domain
    cd00096
    Location:8689
    Ig; Ig strand A [structural motif]
    cd05894
    Location:557642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    cl11960
    Location:85185
    Ig; Immunoglobulin domain
  12. XM_030244822.2XP_030100682.1  myosin-binding protein C, slow-type isoform X16

    UniProtKB/TrEMBL
    A0A571BEN1
    Related
    ENSMUSP00000158844.2, ENSMUST00000238199.2
    Conserved Domains (6) summary
    cd05894
    Location:531616
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:64159
    IG_like; Immunoglobulin like
    cd00063
    Location:620709
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10291118
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:209242
    THB; Tri-helix bundle domain
    cl11960
    Location:838896
    Ig; Immunoglobulin domain
  13. XM_006513058.5XP_006513121.1  myosin-binding protein C, slow-type isoform X15

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:532617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:65160
    IG_like; Immunoglobulin like
    cd00063
    Location:621710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10301119
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:210243
    THB; Tri-helix bundle domain
    cl11960
    Location:839897
    Ig; Immunoglobulin domain
  14. XM_036155499.1XP_036011392.1  myosin-binding protein C, slow-type isoform X18

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd00063
    Location:621710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10301119
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:210243
    THB; Tri-helix bundle domain
    cd00096
    Location:6164
    Ig; Ig strand A [structural motif]
    cd05894
    Location:532617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    cl11960
    Location:60160
    Ig; Immunoglobulin domain
  15. XM_006513055.5XP_006513118.1  myosin-binding protein C, slow-type isoform X11

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:545630
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:78173
    IG_like; Immunoglobulin like
    cd00063
    Location:634723
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10431132
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:223256
    THB; Tri-helix bundle domain
    cl11960
    Location:852910
    Ig; Immunoglobulin domain
  16. XM_036155498.1XP_036011391.1  myosin-binding protein C, slow-type isoform X17

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd00063
    Location:646735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10551144
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:235268
    THB; Tri-helix bundle domain
    cd00096
    Location:8689
    Ig; Ig strand A [structural motif]
    cd05894
    Location:557642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    cl11960
    Location:85185
    Ig; Immunoglobulin domain
  17. XM_006513056.3XP_006513119.1  myosin-binding protein C, slow-type isoform X14

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:518603
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:51146
    IG_like; Immunoglobulin like
    cd00063
    Location:607696
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10341123
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:196229
    THB; Tri-helix bundle domain
    cl11960
    Location:843901
    Ig; Immunoglobulin domain
  18. XM_006513048.3XP_006513111.1  myosin-binding protein C, slow-type isoform X5

    UniProtKB/TrEMBL
    A0A571BEN1
    Conserved Domains (6) summary
    cd05894
    Location:543628
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:76171
    IG_like; Immunoglobulin like
    cd00063
    Location:632721
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10591148
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:221254
    THB; Tri-helix bundle domain
    cl11960
    Location:868926
    Ig; Immunoglobulin domain

RNA

  1. XR_380342.5 RNA Sequence

  2. XR_004936034.1 RNA Sequence