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ADCY2 adenylate cyclase 2 [ Homo sapiens (human) ]

Gene ID: 108, updated on 21-Dec-2019

Summary

Official Symbol
ADCY2provided by HGNC
Official Full Name
adenylate cyclase 2provided by HGNC
Primary source
HGNC:HGNC:233
See related
Ensembl:ENSG00000078295 MIM:103071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AC2; HBAC2
Summary
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 19.2), prostate (RPKM 3.0) and 6 other tissues See more
Orthologs

Genomic context

See ADCY2 in Genome Data Viewer
Location:
5p15.31
Exon count:
26
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (7396138..7830081)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (7396343..7830194)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374645 Neighboring gene uncharacterized LOC107986403 Neighboring gene long intergenic non-protein coding RNA 2142 Neighboring gene uncharacterized LOC105374646 Neighboring gene chromosome 5 open reading frame 49 Neighboring gene FAST kinase domains 3 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association study reveals two new risk loci for bipolar disorder.
NHGRI GWA Catalog
Identification of novel germline polymorphisms governing capecitabine sensitivity.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
Nef nef HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain PubMed
Tat tat HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16822, FLJ45092, KIAA1060, MGC133314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase activity NAS
Non-traceable Author Statement
more info
PubMed 
adenylate cyclase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
 
activation of protein kinase A activity TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
renal water homeostasis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adenylate cyclase type 2
Names
3',5'-cyclic AMP synthetase
ATP pyrophosphate-lyase 2
adenylate cyclase 2 (brain)
adenylate cyclase II
adenylate cyclase type II
adenylyl cyclase 2
type II adenylate cyclase
NP_065433.2
XP_011512244.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046913.1 RefSeqGene

    Range
    4909..438852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020546.3NP_065433.2  adenylate cyclase type 2

    See identical proteins and their annotated locations for NP_065433.2

    Status: REVIEWED

    Source sequence(s)
    AC010346, AC024577, AF070583, BC111743, BE677757, DB029098, DB481853
    Consensus CDS
    CCDS3872.2
    UniProtKB/Swiss-Prot
    Q08462
    UniProtKB/TrEMBL
    Q71UM8
    Related
    ENSP00000342952.4, ENST00000338316.9
    Conserved Domains (4) summary
    smart00044
    Location:236439
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8781077
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:495599
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:33260
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    7396138..7830081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513942.2XP_011512244.1  adenylate cyclase type 2 isoform X1

    Conserved Domains (4) summary
    smart00044
    Location:236439
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8321031
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:495599
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:33260
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RNA

  1. XR_001741973.1 RNA Sequence

  2. XR_427657.2 RNA Sequence

  3. XR_001741974.2 RNA Sequence

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