Conserved Protein Domain Family
CYCc

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smart00044: CYCc 
Adenylyl- / guanylyl cyclase, catalytic domain
Present in two copies in mammalian adenylyl cyclases. Eubacterial homologues are known. Two residues (Asn, Arg) are thought to be involved in catalysis. These cyclases have important roles in a diverse range of cellular processes.
Statistics
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PSSM-Id: 214485
View PSSM: smart00044
Aligned: 32 rows
Threshold Bit Score: 149.715
Threshold Setting Gi: 16330418
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00044 is classified as a model that may span more than one domain.
smart00044 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251824029  960 DERKRNESLLLQLLPKSVANSLKN-Gq----------------------------------------------------- 985
gi 119581448   33 DENEKQERLLMSLLPRNVAMEMKE-Dflkpp------------------------------------------------- 62
gi 6322455   1611 YGCTENITILCLALYENIQQQNRF-Tlnknslmtrrs------------------------------------------- 1646
gi 1196832      1 MREWCMLRESRTNTPRRAAERGKRpGg----------------------------------------------------- 27
gi 19112951  1261 AYGAEKNVLVVIVELNGLFEENSL-Nfnqlrgdektlaiseknd------------------------------------ 1303
gi 39964959  1655 MILLATSELWEHLAPELIVDIARQ-Ergdlmratqklrdlaiaygstnkimimmisvadlkrrtertrinrgqsmsihnl 1733
gi 16330418    16 LEIDSNETILDALLKGDIAHISVC-Ggkancstcrimvldgikncspptsieqalakkldfp------------fhvrla 82
gi 71022299  1966 ARTQRNDPMIAAQKLRDFAISYGA-Eesimvmvisvgdlfyrsdqrnggglnfas------------------------- 2019
gi 3023616    850 IEILSIQRMLDPTVPQLSSPSTPT-Meyrprqrshaltpaqrngliagcv------------------------------ 898
gi 310820741  196 lkrarlgryfspavaeRLQDLDRS-------------------------------------------------------- 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251824029  986 -----------------------------PVDAEFYDSVSIYFSDIVGFTALSsKSTPLQVVNMLNNLYTNFD----TII 1032
gi 119581448   63 ------------------------erifhKIYIQRHDNVSILFADIVGFTGLAsQCTAQELVKLLNELFGKFD----ELA 114
gi 6322455   1647 ------------------tfedttlrrlqPEISPPTGNLAMVFTDIKSSTFLWe-LFPNAMRTAIKTHNDIMR----RQL 1703
gi 1196832     28 ----------------------------sSVRGGERRIVTALCYDLVGSTDLM---HVMDIED-YQELMSAFQlaskQAI 75
gi 19112951  1304 -----------nmsfvqdlpddsslarmnREVSPPKGCIAMVFTDIKNSTLLW-ERHPIAMRSAIKTHNTIMR----RQL 1367
gi 39964959  1734 slhgeqykfptrgrrkkdqvmdstlqrleAEVPAPTGMIAIVFTDIKNSTNL--WETYPAAMRSAIRLHNEMM----RRQ 1807
gi 16330418    83 cqtklsnsatirrlvldegdidlidhqltTGAINTERNVALLMANIRGATNFDeVNFPYDIVYVMGRYFSQMQ----KII 158
gi 71022299  2020 -yknsdaiqkagrrfreelpgdrtlarldREVAPPIGQVALVFTDIKNSTSLWeTNNGMQTAMRLHNYLLRRQ----LRT 2094
gi 3023616    899 -----vgavvliatctlllyccmdnrnndAAPKDGDEPVTLLFTDIESSTALW-AALPQLMSDAIAAHHRVIR----QLV 968
gi 310820741  220 ------------------------------ETSPELREVTLLFADIRDFTSLSeRLRPEQVVTLLNEYYGRMV----EVV 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251824029 1033 DKFD-CYKVETIGDAYMFVSGLPEVNS-----------------------YLHAGEVASASLELLDSIKTFTVSHCp--- 1085
gi 119581448  115 TENH-CRRIKILGDCYYCVSGLTQPKT------------------------DHAHCCVEMGLDMIDTITSV-AEAT---- 164
gi 6322455   1704 RIYG-GYEVKTEGDAFMVAFPTPTSGLtwc------------------lsVQLKLLDAQWPEEITSVQDGCQVTDRngni 1764
gi 1196832     76 ASHS-GVMQHEAGDGGVALFPIELEAK------------------------DAASLAIRAGLGIVEACKRVGREAG---- 126
gi 19112951  1368 RATG-GYEVKTEGDAFMVCFQTVPAALlwc------------------fsVQLQLLSADWPNEIVESVQGRLVLGSknev 1428
gi 39964959  1808 LRRIgGFEVKTEGDAFMVSFPTATSALlwcf---------------avqlQLLEVNWPSEMLNSLSCKPTVDKNNQv--- 1869
gi 16330418   159 EKYG-GTISNVMGRKMLVAFGLKEFDVs---------------------aAERATWAALEMFKSVQELNTLLNQMr---- 212
gi 71022299  2095 IG---GYEVKTEGDAFMVSFPSVSAALlwc------------------ftVQQQLLQEDWPREILDSEDGKEVYDQsgel 2153
gi 3023616    969 KKYG-CYEVKTIGDSFMIACRSAHSAVslaceiqtkllkhdwgtealdraYREFELARVDTLDDYEPPTARLSEEEya-a 1046
gi 310820741  266 FRHG-GTLDKFIGDALMVYFGAPIAd------------------------PAHARRGVQCALDMVQELETVNALRSar-- 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251824029 1086 -DEKLRLRIGNHTGPVVTGVVGIRm--P-RYCLFGDTVIIANMMESSGEPM--RIQISSDAYELI--------LkCGGYV 1151
gi 119581448  165 -EVDLNMRVGLHTGRVLCGVLGLRk--W-QYDVWSNDVTLANVMEAAGLPG--KVHITKTTLACL--------NgDYEve 230
gi 6322455   1765 iYQGLSVRMGIHWGCPVPELDLVTq----RMDYLGPMVNKAARVQGVADGG--QIAMSSDFYSEFn---------KIMKY 1829
gi 1196832    127 -QDDLQVRVGIATSVALVLEGSREg--WtREPVTGAALAMAARLQAITAPN--SVLVSEETRH-L--------AgRSYAF 192
gi 19112951  1429 lYRGLSVRIGVNYGVTVSELDPIT---R-RMDYYGPVVNRTSRVVSVADGG--QIAVSAEVVSVLnqldsetmSsEKTNV 1502
gi 39964959  1870 iFKGLSVRMGIHWGEPLCEPDPIt---R-RMDYYGPMVNKASRISAVADGG--QITVSSDFISEI--------QrCLETY 1935
gi 16330418   213 -YRPLNLSMGIHSGSVVFVPLVAAq-sT-LLTPLGEVAAIVNLLESANKLKgtQLLVSQDVYQVIkn-----qArVGNQI 284
gi 71022299  2154 iHRGLSVRMGIHWGRPVCEADPIT---R-RMDYFGPMVNRAARISGAADGG--QILASKDVIKEL--------QgLLGTF 2219
gi 3023616   1047 lWCGLRVRVGIHTGLTDIRYDEVT---K-GYDYYGDTSNMAARTEAVANGG--QVVATEAAWWALs---------NDERA 1111
gi 310820741  319 gEPCLRIGVGVHTGPAVLGNIGSAtrrL-EYTAIGDTVNLASRIESLTKTR--DVPILASRATREq---------AGDTF 386

                  ..
gi 251824029 1152 TE 1153
gi 119581448  231 pg 232
gi 6322455   1830 HE 1831
gi 1196832    193 VF 194
gi 19112951  1503 NE 1504
gi 39964959  1936 QG 1937
gi 16330418   285 IL 286
gi 71022299  2220 DE 2221
gi 3023616   1112 GI 1113
gi 310820741  387 LW 388
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