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CENPA centromere protein A [ Homo sapiens (human) ]

Gene ID: 1058, updated on 24-May-2020

Summary

Official Symbol
CENPAprovided by HGNC
Official Full Name
centromere protein Aprovided by HGNC
Primary source
HGNC:HGNC:1851
See related
Ensembl:ENSG00000115163 MIM:117139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CenH3; CENP-A
Summary
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
Expression
Broad expression in lymph node (RPKM 4.5), appendix (RPKM 2.5) and 14 other tissues See more
Orthologs

Genomic context

See CENPA in Genome Data Viewer
Location:
2p23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (26786015..26794589)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27008857..27023935)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 3 Neighboring gene solute carrier family 35 member F6 Neighboring gene CDKN2A interacting protein N-terminal like pseudogene 2 Neighboring gene dihydropyrimidinase like 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr and p300/HAT co-localizes with CENP-A and CENP-H proteins in the centromere and arm region of chromosome PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore assembly IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome inner kinetochore IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H3-like centromeric protein A
Names
centromere autoantigen A
centromere protein A, 17kDa
centromere-specific histone

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042426.1NP_001035891.1  histone H3-like centromeric protein A isoform b

    See identical proteins and their annotated locations for NP_001035891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AC011740, BC000881
    Consensus CDS
    CCDS42662.1
    UniProtKB/Swiss-Prot
    P49450
    Related
    ENSP00000233505.8, ENST00000233505.12
    Conserved Domains (1) summary
    cl23735
    Location:34111
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
  2. NM_001809.4NP_001800.1  histone H3-like centromeric protein A isoform a

    See identical proteins and their annotated locations for NP_001800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC011740
    Consensus CDS
    CCDS1729.1
    UniProtKB/Swiss-Prot
    P49450
    Related
    ENSP00000336868.4, ENST00000335756.9
    Conserved Domains (1) summary
    smart00428
    Location:34137
    H3; Histone H3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    26786015..26794589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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