U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cenpa centromere protein A [ Mus musculus (house mouse) ]

Gene ID: 12615, updated on 24-Jan-2023

Summary

Official Symbol
Cenpaprovided by MGI
Official Full Name
centromere protein Aprovided by MGI
Primary source
MGI:MGI:88375
See related
Ensembl:ENSMUSG00000029177 AllianceGenome:MGI:88375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cenp-A
Summary
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
Expression
Broad expression in CNS E11.5 (RPKM 43.5), liver E14.5 (RPKM 41.9) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cenpa in Genome Data Viewer
Location:
5 B1; 5 16.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30824214..30832181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30666877..30674837)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9899 Neighboring gene potassium channel, subfamily K, member 3 Neighboring gene solute carrier family 35, member F6 Neighboring gene microRNA 5625 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene autophagy-related 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in CENP-A containing chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of CENP-A containing nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H3-like centromeric protein A
Names
centromere autoantigen A
centrosomin A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302129.1NP_001289058.1  histone H3-like centromeric protein A isoform 2

    See identical proteins and their annotated locations for NP_001289058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC105298, AF012709, AK011399, AK041138, BQ748418, BY136144
    UniProtKB/Swiss-Prot
    O35216
    Conserved Domains (1) summary
    smart00428
    Location:3105
    H3; Histone H3
  2. NM_001302130.1NP_001289059.1  histone H3-like centromeric protein A isoform 2

    See identical proteins and their annotated locations for NP_001289059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC105298, AF012709, AK011399, AK041138, BQ748418, BY136144
    UniProtKB/Swiss-Prot
    O35216
    Conserved Domains (1) summary
    smart00428
    Location:3105
    H3; Histone H3
  3. NM_001302131.1NP_001289060.1  histone H3-like centromeric protein A isoform 2

    See identical proteins and their annotated locations for NP_001289060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC105298, AF012709, AK011399, AK041138, BQ748418, BY136144
    UniProtKB/Swiss-Prot
    O35216
    Conserved Domains (1) summary
    smart00428
    Location:3105
    H3; Histone H3
  4. NM_001302132.1NP_001289061.1  histone H3-like centromeric protein A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a 3' exon, which results in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA016357, AC105298, AF012709, AK011399, BQ748418, BY136144
    UniProtKB/Swiss-Prot
    O35216
    Related
    ENSMUSP00000143575.2, ENSMUST00000199320.5
    Conserved Domains (1) summary
    cl23735
    Location:2890
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
  5. NM_007681.3NP_031707.1  histone H3-like centromeric protein A isoform 1

    See identical proteins and their annotated locations for NP_031707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC105298, AF012709, AK011399, BQ748418, BY136144
    Consensus CDS
    CCDS19162.1
    UniProtKB/Swiss-Prot
    O35216, Q545C9
    Related
    ENSMUSP00000122831.2, ENSMUST00000144742.6
    Conserved Domains (2) summary
    smart00428
    Location:28131
    H3; Histone H3
    pfam00125
    Location:1127
    Histone; Core histone H2A/H2B/H3/H4

RNA

  1. NR_126074.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105298, AF012709, AK011399, BQ748418, BY136144

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30824214..30832181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240699.4XP_011239001.1  histone H3-like centromeric protein A isoform X1

    Conserved Domains (1) summary
    smart00428
    Location:41143
    H3; Histone H3
  2. XM_036164762.1XP_036020655.1  histone H3-like centromeric protein A isoform X2

    Conserved Domains (1) summary
    smart00428
    Location:3105
    H3; Histone H3

RNA

  1. XR_004942431.1 RNA Sequence