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LAMC3 laminin subunit gamma 3 [ Homo sapiens (human) ]

Gene ID: 10319, updated on 1-Jun-2020

Summary

Official Symbol
LAMC3provided by HGNC
Official Full Name
laminin subunit gamma 3provided by HGNC
Primary source
HGNC:HGNC:6494
See related
Ensembl:ENSG00000050555 MIM:604349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCCM
Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]
Expression
Biased expression in placenta (RPKM 45.0), testis (RPKM 15.3) and 7 other tissues See more
Orthologs

Genomic context

See LAMC3 in Genome Data Viewer
Location:
9q34.12
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (131009174..131094473)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133884504..133968446)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene fibrinogen C domain containing 1 Neighboring gene uncharacterized LOC105376297 Neighboring gene LAMC3 intron enhancer-blocking element 9-5 Neighboring gene LAMC3 intron enhancer-blocking element 9-2 Neighboring gene allograft inflammatory factor 1 like Neighboring gene RNA, U6 small nuclear 881, pseudogene Neighboring gene nucleoporin 214

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434E202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
laminin subunit gamma-3
Names
laminin, gamma 3
laminin-12 subunit gamma
laminin-14 subunit gamma
laminin-15 subunit gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029800.1 RefSeqGene

    Range
    5058..90357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006059.4NP_006050.3  laminin subunit gamma-3 precursor

    See identical proteins and their annotated locations for NP_006050.3

    Status: REVIEWED

    Source sequence(s)
    AB208887, AF041835, AK075536, AL157938, AL355872, AL551493, BX327938, R45355
    Consensus CDS
    CCDS6938.1
    UniProtKB/Swiss-Prot
    Q9Y6N6
    UniProtKB/TrEMBL
    Q8N2D6
    Related
    ENSP00000354360.4, ENST00000361069.9
    Conserved Domains (7) summary
    cd00055
    Location:706753
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:541662
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:917965
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:44269
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam04012
    Location:11911420
    PspA_IM30; PspA/IM30 family
    pfam14662
    Location:13381518
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl21478
    Location:13541447
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    131009174..131094473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518121.1XP_011516423.1  laminin subunit gamma-3 isoform X1

    Conserved Domains (6) summary
    cd00055
    Location:706753
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:541662
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:917965
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:44269
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam04012
    Location:11911426
    PspA_IM30; PspA/IM30 family
    cl21478
    Location:13601453
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. XM_006716921.2XP_006716984.1  laminin subunit gamma-3 isoform X2

    Conserved Domains (5) summary
    cd00055
    Location:706748
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:541662
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:917965
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:44269
    Laminin_N; Laminin N-terminal (Domain VI)
    cl22855
    Location:684777
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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