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Lamc3 laminin gamma 3 [ Mus musculus (house mouse) ]

Gene ID: 23928, updated on 11-Jun-2024

Summary

Official Symbol
Lamc3provided by MGI
Official Full Name
laminin gamma 3provided by MGI
Primary source
MGI:MGI:1344394
See related
Ensembl:ENSMUSG00000026840 AllianceGenome:MGI:1344394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110064A23Rik
Summary
Acts upstream of or within several processes, including astrocyte development; retina development in camera-type eye; and visual perception. Located in basement membrane. Is expressed in central nervous system; lower jaw molar epithelium; oral region gland; retina; and vibrissa. Orthologous to human LAMC3 (laminin subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 25.0), adrenal adult (RPKM 10.6) and 12 other tissues See more
Orthologs
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Genomic context

See Lamc3 in Genome Data Viewer
Location:
2; 2 B
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31777293..31839095)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31887281..31949083)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene c-abl oncogene 1, non-receptor tyrosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E10093 Neighboring gene fibrinogen C domain containing 1 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene STARR-seq mESC enhancer starr_04163 Neighboring gene allograft inflammatory factor 1-like Neighboring gene nucleoporin 214 Neighboring gene BTG3 associated nuclear protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within astrocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retina development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within visual perception IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
laminin subunit gamma-3
Names
laminin-12 subunit gamma
laminin-14 subunit gamma
laminin-15 subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011836.4NP_035966.2  laminin subunit gamma-3 precursor

    See identical proteins and their annotated locations for NP_035966.2

    Status: VALIDATED

    Source sequence(s)
    AL928893, BX511243
    Consensus CDS
    CCDS15903.1
    UniProtKB/Swiss-Prot
    Q4VAI3, Q9R0B6, Q9WTW6
    UniProtKB/TrEMBL
    A2ATM9
    Related
    ENSMUSP00000028187.7, ENSMUST00000028187.7
    Conserved Domains (6) summary
    cd00055
    Location:391437
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:550669
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:928976
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:53278
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06008
    Location:12251470
    Laminin_I; Laminin Domain I
    cl14813
    Location:14331506
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    31777293..31839095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)