1KLO


Conserved Protein Domain Family
EGF_Lam

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cd00055: EGF_Lam 
Click on image for an interactive view with Cn3D
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Links
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Statistics
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PSSM-Id: 238012
View PSSM: cd00055
Aligned: 317 rows
Threshold Bit Score: 29.2446
Threshold Setting Gi: 2497597
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
EGF-like motif
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:EGF-like motif
Evidence:
  • Comment:structurally similar to epidermal growth factor (EGF)
  • Citation:PMID 8648630

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1       # #           #      #  #        #                      
1KLO        55 PCQCNDNIdpnavgnCNrlTGECLkCIYNTAGFYCD-RCKEGFFGNplapnpadKCK 110  house mouse
2506805    756 PCQCFGHAe-----sCDdvTGECLnCKDHTGGPYCD-KCLPGFYGEptkg-tseDCQ 805  human
Q9Y6N6     706 PCTCNQHGt------CDpnTGICV-CSHHTEGPSCE-RCLPGFYGNpfag-qadDCQ 753  human
AAF52597  1232 PCECNGHGnqd-lgvCNvsNGECY-CKDNTQGLNCE-LCAPGYYGDprg---ggKCY 1282 fruit fly
T00209     102 PCQCNGHGdpr-rghCDnlSGLCF-CQDHTEGAHCQ-LCSPGYYGDpra---ggSCF 152  human
AAF52597  1185 SCGCNNHSt------CNerLGKCDqCQDWSEGEKCE-RCRQGSYGNata---phGCL 1231 fruit fly
NP_476790 1247 CSACRSEGq-----vCDphNGRCI-CPKFTRGLGCG-QCVPGTWGWqa----rlGCR 1292 fruit fly
126363     997 PCDCPHTQn-----tCDpeTGECV-CPPHTQGGKCE-ECEDGHWGYda----evGCQ 1042 human
2506805   1013 ACECSHLGn-----nCDpkTGRCI-CPPNTIGEKCS-KCAPNTWGHsi----ttGCK 1058 human
P35590     228 CPGCLHGGv------CHdhDGECV-CPPGFTGTRCEqACREGRFGQ--------SCQ 269  human

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