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ZNF559-ZNF177 ZNF559-ZNF177 readthrough [ Homo sapiens (human) ]

Gene ID: 100529215, updated on 8-Dec-2022

Summary

Official Symbol
ZNF559-ZNF177provided by HGNC
Official Full Name
ZNF559-ZNF177 readthroughprovided by HGNC
Primary source
HGNC:HGNC:42964
See related
Ensembl:ENSG00000270011 AllianceGenome:HGNC:42964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSeq, Jan 2011]
Expression
Broad expression in testis (RPKM 5.0), ovary (RPKM 3.1) and 22 other tissues See more
Orthologs
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Genomic context

See ZNF559-ZNF177 in Genome Data Viewer
Location:
19p13.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9324179..9382617)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9450390..9508854)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9434855..9493293)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily H member 1 pseudogene Neighboring gene zinc finger protein 699 Neighboring gene zinc finger protein 559 Neighboring gene UBX domain protein 2A pseudogene Neighboring gene zinc finger protein 177 Neighboring gene uncharacterized LOC112268250 Neighboring gene zinc finger protein 266

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172650.3NP_001166121.1  zinc finger protein 177 isoform b

    See identical proteins and their annotated locations for NP_001166121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate exon structure in the 5' UTR, uses an alternate splice site that causes a frameshift in the 3' coding region, and lacks a segment of the 3' UTR, compared to variant 4. The resulting isoform (b) has a distinct and longer C-terminus, compared to isoform c. A non-read-through variant of the downstream ZNF177 gene, as represented by GeneID:7730, also encodes isoform b.
    Source sequence(s)
    AC011451, BC034489
    UniProtKB/Swiss-Prot
    Q13360
    Related
    ENSP00000445323.1, ENST00000541595.6
    Conserved Domains (4) summary
    smart00349
    Location:1470
    KRAB; krueppel associated box
    COG5048
    Location:87282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:126146
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:279303
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001202425.1NP_001189354.1  zinc finger protein 177 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longer transcript but encodes the shorter isoform (c).
    Source sequence(s)
    AC011451, BC034489, U37251
    UniProtKB/Swiss-Prot
    Q13360
    Related
    ENSP00000413568.2, ENST00000446085.8
    Conserved Domains (2) summary
    smart00349
    Location:1470
    KRAB; krueppel associated box
    pfam01352
    Location:1453
    KRAB; KRAB box
  3. NM_001384659.1NP_001371588.1  zinc finger protein 177 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC011451
    UniProtKB/Swiss-Prot
    Q96ER2
    Conserved Domains (4) summary
    smart00349
    Location:1470
    KRAB; krueppel associated box
    COG5048
    Location:212442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:439463
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9324179..9382617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9450390..9508854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)