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ZNF559 zinc finger protein 559 [ Homo sapiens (human) ]

Gene ID: 84527, updated on 25-Jan-2022

Summary

Official Symbol
ZNF559provided by HGNC
Official Full Name
zinc finger protein 559provided by HGNC
Primary source
HGNC:HGNC:28197
See related
Ensembl:ENSG00000188321 AllianceGenome:HGNC:28197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBLA00121
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in ovary (RPKM 6.6), endometrium (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF559 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (9323772..9345871)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9434448..9456547)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily H member 1 pseudogene Neighboring gene zinc finger protein 699 Neighboring gene ZNF559-ZNF177 readthrough Neighboring gene UBX domain protein 2A pseudogene Neighboring gene zinc finger protein 177

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF559-ZNF177

Readthrough gene: ZNF559-ZNF177, Included gene: ZNF177

Homology

Clone Names

  • MGC13105

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 559
Names
putative protein product of Nbla00121

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202406.1NP_001189335.1  zinc finger protein 559 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK056489, AK298169, BU608632, DA457855, DA731101
    Consensus CDS
    CCDS62531.1
    UniProtKB/TrEMBL
    A0A0A0MTT2, B3KPL8, B4DP29
    Related
    ENSP00000468153.2, ENST00000587557.5
    Conserved Domains (6) summary
    smart00349
    Location:78118
    KRAB; krueppel associated box
    COG5048
    Location:212601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:391411
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:445467
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:78117
    KRAB; KRAB box
    pfam13465
    Location:431454
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001202407.3NP_001189336.1  zinc finger protein 559 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional exon in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC011451
    UniProtKB/TrEMBL
    B4DP29
    Conserved Domains (3) summary
    COG5048
    Location:106495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:325348
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001202408.1NP_001189337.1  zinc finger protein 559 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site that causes a frameshift in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AK298169, AK308517, BU608632, DA457855, DA731101
    UniProtKB/TrEMBL
    B4DP29
    Conserved Domains (2) summary
    smart00349
    Location:78118
    KRAB; krueppel associated box
    pfam01352
    Location:78117
    KRAB; KRAB box
  4. NM_001202409.2NP_001189338.1  zinc finger protein 559 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an additional segment in its 5' UTR, uses a distinct start codon, uses an alternate splice site that causes a frameshift in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (e) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AK298169, AK310020, BU608632, DA731101
    Consensus CDS
    CCDS62532.1
    UniProtKB/TrEMBL
    A0A0A0MTS4, B4DP29
    Related
    ENSP00000466496.2, ENST00000592896.5
    Conserved Domains (2) summary
    smart00349
    Location:4282
    KRAB; krueppel associated box
    pfam01352
    Location:4281
    KRAB; KRAB box
  5. NM_001202410.2NP_001189339.1  zinc finger protein 559 isoform f

    See identical proteins and their annotated locations for NP_001189339.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an additional exon in its 5' UTR, uses a downstream start codon, uses an alternate splice site that causes a frameshift in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (f) has a shorter N-terminus, a distinct C-terminus, and is overall shorter than isoform a. Variants 6, 7 and 8 all encode isoform f.
    Source sequence(s)
    AK027700, BU608632
    Consensus CDS
    CCDS59349.1
    UniProtKB/Swiss-Prot
    Q9BR84
    Related
    ENSP00000325393.7, ENST00000317221.11
    Conserved Domains (1) summary
    pfam01352
    Location:1354
    KRAB; KRAB box
  6. NM_001202411.2NP_001189340.1  zinc finger protein 559 isoform f

    See identical proteins and their annotated locations for NP_001189340.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes an additional exon in its 5' UTR, uses a downstream start codon, uses an alternate splice site that causes a frameshift in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (f) has a shorter N-terminus, a distinct C-terminus, and is overall shorter than isoform a. Variants 6, 7 and 8 all encode isoform f.
    Source sequence(s)
    AC011451
    Consensus CDS
    CCDS59349.1
    UniProtKB/TrEMBL
    B4DP29, Q3LIC1
    Conserved Domains (1) summary
    pfam01352
    Location:1354
    KRAB; KRAB box
  7. NM_001202412.2NP_001189341.1  zinc finger protein 559 isoform f

    See identical proteins and their annotated locations for NP_001189341.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes two alternate exons in its 5' UTR, uses a downstream start codon, uses an alternate splice site that causes a frameshift in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (f) has a shorter N-terminus, a distinct C-terminus, and is overall shorter than isoform a. Variants 6, 7 and 8 all encode isoform f.
    Source sequence(s)
    AC011451, AK027700, BP337457, BU608632, DA509657, DB158737
    Consensus CDS
    CCDS59349.1
    UniProtKB/Swiss-Prot
    Q9BR84
    Related
    ENSP00000468299.1, ENST00000592298.5
    Conserved Domains (1) summary
    pfam01352
    Location:1354
    KRAB; KRAB box
  8. NM_032497.3NP_115886.1  zinc finger protein 559 isoform b

    See identical proteins and their annotated locations for NP_115886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC011451, AK298169, BU608632, CF597362
    Consensus CDS
    CCDS12211.1
    UniProtKB/Swiss-Prot
    Q9BR84
    UniProtKB/TrEMBL
    A0A024R7B5, B4DP29
    Related
    ENSP00000474760.1, ENST00000603380.6
    Conserved Domains (3) summary
    COG5048
    Location:148537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    9323772..9345871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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