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ZNF177 zinc finger protein 177 [ Homo sapiens (human) ]

Gene ID: 7730, updated on 23-Nov-2023

Summary

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Official Symbol
ZNF177provided by HGNC
Official Full Name
zinc finger protein 177provided by HGNC
Primary source
HGNC:HGNC:12966
See related
Ensembl:ENSG00000188629 MIM:601276; AllianceGenome:HGNC:12966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIGX
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in blood microparticle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.2), ovary (RPKM 3.1) and 21 other tissues See more
Orthologs
all
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Genomic context

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See ZNF177 in Genome Data Viewer
Location:
19p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9363013..9382617)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9489226..9508854)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9473689..9493293)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF559-ZNF177 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10038 Neighboring gene zinc finger protein 559 Neighboring gene UBX domain protein 2A pseudogene Neighboring gene uncharacterized LOC112268250 Neighboring gene zinc finger protein 266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. Landry JR, et al. Genomics, 2001 Aug. PMID 11549323
  2. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. Baban S, et al. Genomics, 1996 May 1. PMID 8661005
  3. NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA. Wei X, et al. PLoS Pathog, 2019 Nov. PMID 31751430, Free PMC Article
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article
  5. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF559-ZNF177

Readthrough gene: ZNF559-ZNF177, Included gene: ZNF559

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 177

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172651.2 → NP_001166122.1  zinc finger protein 177 isoform a

    See identical proteins and their annotated locations for NP_001166122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC011451
    Consensus CDS
    CCDS54214.1
    UniProtKB/Swiss-Prot
    B4DY57, E9PDG0, I3L0I4, Q13360, Q96ER2
    Related
    ENSP00000507083.1, ENST00000683217.1
    Conserved Domains (4) summary
    smart00349
    Location:14 → 70
    KRAB; krueppel associated box
    COG5048
    Location:212 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:439 → 463
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001384658.1 → NP_001371587.1  zinc finger protein 177 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC011451
    Conserved Domains (4) summary
    smart00349
    Location:14 → 70
    KRAB; krueppel associated box
    COG5048
    Location:87 → 282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:126 → 146
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:279 → 303
    zf-H2C2_2; Zinc-finger double domain

  3. NM_003451.3 → NP_003442.2  zinc finger protein 177 isoform b

    See identical proteins and their annotated locations for NP_003442.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents additional exons in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. A ZNF559-ZNF177 read-through variant, as represented by GeneID:100529215, also encodes isoform b.
    Source sequence(s)
    AC011451, BC012012, BX114567, U37263
    UniProtKB/Swiss-Prot
    Q13360
    Related
    ENSP00000341497.3, ENST00000343499.8
    Conserved Domains (4) summary
    smart00349
    Location:14 → 70
    KRAB; krueppel associated box
    COG5048
    Location:87 → 282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:126 → 146
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:279 → 303
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9363013..9382617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9489226..9508854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13360.4 GenPept UniProtKB/Swiss-Prot:Q13360

Gene LinkOut

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