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ZNF177 zinc finger protein 177 [ Homo sapiens (human) ]

Gene ID: 7730, updated on 23-Nov-2021

Summary

Official Symbol
ZNF177provided by HGNC
Official Full Name
zinc finger protein 177provided by HGNC
Primary source
HGNC:HGNC:12966
See related
Ensembl:ENSG00000188629 Ensembl:ENSG00000270011 MIM:601276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIGX
Expression
Broad expression in testis (RPKM 5.2), ovary (RPKM 3.1) and 21 other tissues See more
Orthologs
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Genomic context

See ZNF177 in Genome Data Viewer
Location:
19p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (9363013..9382617)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9473689..9493293)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF559-ZNF177 readthrough Neighboring gene zinc finger protein 559 Neighboring gene UBX domain protein 2A pseudogene Neighboring gene uncharacterized LOC112268250 Neighboring gene zinc finger protein 266

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF559-ZNF177

Readthrough gene: ZNF559-ZNF177, Included gene: ZNF559

Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172651.2NP_001166122.1  zinc finger protein 177 isoform a

    See identical proteins and their annotated locations for NP_001166122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC011451
    Consensus CDS
    CCDS54214.1
    UniProtKB/Swiss-Prot
    Q13360
    UniProtKB/TrEMBL
    A0A0A6YYI6
    Related
    ENSP00000507083.1, ENST00000683217.1
    Conserved Domains (4) summary
    smart00349
    Location:1470
    KRAB; krueppel associated box
    COG5048
    Location:212442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:439463
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001384658.1NP_001371587.1  zinc finger protein 177 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC011451
    Conserved Domains (4) summary
    smart00349
    Location:1470
    KRAB; krueppel associated box
    COG5048
    Location:87282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:126146
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:279303
    zf-H2C2_2; Zinc-finger double domain
  3. NM_003451.3NP_003442.2  zinc finger protein 177 isoform b

    See identical proteins and their annotated locations for NP_003442.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents additional exons in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. A ZNF559-ZNF177 read-through variant, as represented by GeneID:100529215, also encodes isoform b.
    Source sequence(s)
    AC011451, BC012012, BX114567, U37263
    Consensus CDS
    CCDS12212.1
    UniProtKB/Swiss-Prot
    Q13360
    Related
    ENSP00000341497.3, ENST00000343499.8
    Conserved Domains (4) summary
    smart00349
    Location:1470
    KRAB; krueppel associated box
    COG5048
    Location:87282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:126146
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:279303
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    9363013..9382617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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