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LY75-CD302 LY75-CD302 readthrough [ Homo sapiens (human) ]

Gene ID: 100526664, updated on 23-Nov-2021

Summary

Official Symbol
LY75-CD302provided by HGNC
Official Full Name
LY75-CD302 readthroughprovided by HGNC
Primary source
HGNC:HGNC:38828
See related
Ensembl:ENSG00000248672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY75; CD205; Ly-75; CLEC13B; DEC-205; gp200-MR6
Summary
This locus represents naturally occurring read-through transcription between the neighboring lymphocyte antigen 75 (LY75) and CD302 molecule (CD302) genes. Alternative splicing results in multiple transcript variants encoding fusion products that share sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in liver (RPKM 22.9), lung (RPKM 17.6) and 25 other tissues See more
Orthologs
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Genomic context

See LY75-CD302 in Genome Data Viewer
Location:
2q24.2
Exon count:
39
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (159768628..159904756, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160625139..160761267, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene BAZ2B antisense RNA 1 Neighboring gene RPS3A pseudogene 13 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene CD302 molecule Neighboring gene lymphocyte antigen 75 Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717 Neighboring gene integrin subunit beta 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Readthrough LY75-CD302

Included genes: LY75, CD302

Homology

General protein information

Preferred Names
LY75-CD302 fusion protein
Names
C-type lectin domain family 13 member B
DEC-205/DCL-1 fusion
Lymphocyte antigen 75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198759.1NP_001185688.1  LY75-CD302 fusion protein isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as V34-2) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC009961, AC093873, AY184222
    Consensus CDS
    CCDS56141.1
    UniProtKB/Swiss-Prot
    O60449
    Related
    ENSP00000423463.1, ENST00000504764.5
    Conserved Domains (5) summary
    smart00059
    Location:162209
    FN2; Fibronectin type 2 domain
    cd00037
    Location:11151222
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:361486
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:38112
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:40125
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
  2. NM_001198760.1NP_001185689.1  LY75-CD302 fusion protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as V33-2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC009961, AC093873, AY314006
    Consensus CDS
    CCDS56140.1
    UniProtKB/Swiss-Prot
    O60449
    Related
    ENSP00000421035.1, ENST00000505052.1
    Conserved Domains (5) summary
    smart00059
    Location:162209
    FN2; Fibronectin type 2 domain
    cd00037
    Location:11151222
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:361486
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:38112
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:40125
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    159768628..159904756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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