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LY75 lymphocyte antigen 75 [ Homo sapiens (human) ]

Gene ID: 4065, updated on 1-Jun-2020

Summary

Official Symbol
LY75provided by HGNC
Official Full Name
lymphocyte antigen 75provided by HGNC
Primary source
HGNC:HGNC:6729
See related
Ensembl:ENSG00000054219 MIM:604524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD205; LY-75; CLEC13B; DEC-205; GP200-MR6
Expression
Broad expression in lymph node (RPKM 17.2), appendix (RPKM 13.2) and 17 other tissues See more
Orthologs

Genomic context

See LY75 in Genome Data Viewer
Location:
2q24.2
Exon count:
35
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (159803355..159904756, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160659866..160761267, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene RPS3A pseudogene 13 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene LY75-CD302 readthrough Neighboring gene CD302 molecule Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717 Neighboring gene integrin subunit beta 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LY75 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with LY75; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of lymphocyte antigen 75 (LY75) in primary human brain microvascular endothelial cells PubMed
capsid gag When introduced the HIV p24 gag protein into a mAb that targets DEC-205/CD205, an endocytic receptor of DCs, low doses of alphaDEC-gag, but not control Ig-gag, stimulates proliferation and IFN-gamma production by CD8+ T cells from HIV-infected donors PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Readthrough LY75-CD302

Readthrough gene: LY75-CD302, Included gene: CD302

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
lymphocyte antigen 75
Names
C-type lectin domain family 13 member B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002349.4NP_002340.2  lymphocyte antigen 75 precursor

    See identical proteins and their annotated locations for NP_002340.2

    Status: VALIDATED

    Source sequence(s)
    AA279177, AB208915, AF011333, AU099700, DB135177, DB146492, DB150194
    Consensus CDS
    CCDS2211.1
    UniProtKB/Swiss-Prot
    O60449
    UniProtKB/TrEMBL
    Q59H44
    Related
    ENSP00000263636.4, ENST00000263636.5
    Conserved Domains (5) summary
    smart00059
    Location:162209
    FN2; Fibronectin type 2 domain
    cd00037
    Location:11151222
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:361486
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:38112
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:40125
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    159803355..159904756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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