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CD302 CD302 molecule [ Homo sapiens (human) ]

Gene ID: 9936, updated on 7-Jun-2020

Summary

Official Symbol
CD302provided by HGNC
Official Full Name
CD302 moleculeprovided by HGNC
Primary source
HGNC:HGNC:30843
See related
Ensembl:ENSG00000241399 MIM:612246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCL1; DCL-1; BIMLEC; CLEC13A
Summary
CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]
Expression
Ubiquitous expression in liver (RPKM 51.3), lung (RPKM 34.3) and 25 other tissues See more
Orthologs

Genomic context

See CD302 in Genome Data Viewer
Location:
2q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (159768628..159798255, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160625139..160655115, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene uncharacterized LOC643072 Neighboring gene RPS3A pseudogene 13 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene LY75-CD302 readthrough Neighboring gene lymphocyte antigen 75 Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD302 (DCL1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough LY75-CD302

Readthrough gene: LY75-CD302, Included gene: LY75

Homology

Clone Names

  • FLJ43091, KIAA0022, MGC22301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microvillus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD302 antigen
Names
C-type lectin domain family 13, member A
DEC205-associated C-type lectin 1
type I transmembrane C-type lectin receptor DCL-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198763.1NP_001185692.1  CD302 antigen isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC009961, AK304422, CB240843, DB217404
    Consensus CDS
    CCDS56139.1
    UniProtKB/Swiss-Prot
    Q8IX05
    Related
    ENSP00000394301.2, ENST00000429078.6
    Conserved Domains (1) summary
    smart00034
    Location:2498
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  2. NM_001198764.1NP_001185693.1  CD302 antigen isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC009961, CB240843, DB217404, DB460994
    Consensus CDS
    CCDS74595.1
    UniProtKB/TrEMBL
    A0A087WT00
    Related
    ENSP00000451446.2, ENST00000553424.5
    Conserved Domains (1) summary
    smart00034
    Location:25117
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  3. NM_014880.5NP_055695.2  CD302 antigen isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009961, AK291279, AY314007, CB240843
    Consensus CDS
    CCDS33308.1
    UniProtKB/Swiss-Prot
    Q8IX05
    Related
    ENSP00000259053.4, ENST00000259053.6
    Conserved Domains (1) summary
    smart00034
    Location:24154
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    159768628..159798255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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