Conserved Protein Domain Family
CLECT

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cd00037: CLECT 
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C-type lectin (CTL)/C-type lectin-like (CTLD) domain
CLECT: C-type lectin (CTL)/C-type lectin-like (CTLD) domain; protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. This group is chiefly comprised of eukaryotic CTLDs, but contains some, as yet functionally uncharacterized, bacterial CTLDs. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces, including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. For example: mannose-binding lectin and lung surfactant proteins A and D bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, and apoptotic cells) and mediate functions associated with killing and phagocytosis; P (platlet)-, E (endothelial)-, and L (leukocyte)- selectins (sels) mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. Several CTLDs bind to protein ligands, and only some of these binding interactions are Ca2+-dependent; including the CTLDs of Coagulation Factors IX/X (IX/X) and Von Willebrand Factor (VWF) binding proteins, and natural killer cell receptors. C-type lectins, such as lithostathine, and some type II antifreeze glycoproteins function in a Ca2+-independent manner to bind inorganic surfaces. Many proteins in this group contain a single CTLD; these CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers, from which ligand-binding sites project in different orientations. Various vertebrate type 1 transmembrane proteins including macrophage mannose receptor, endo180, phospholipase A2 receptor, and dendritic and epithelial cell receptor (DEC205) have extracellular domains containing 8 or more CTLDs; these CTLDs remain in the parent model. In some members (IX/X and VWF binding proteins), a loop extends to the adjoining domain to form a loop-swapped dimer. A similar conformation is seen in the macrophage mannose receptor CRD4's putative non-sugar bound form of the domain in the acid environment of the endosome. Lineage specific expansions of CTLDs have occurred in several animal lineages including Drosophila melanogaster and Caenorhabditis elegans; these CTLDs also remain in the parent model.
Statistics
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PSSM-Id: 153057
View PSSM: cd00037
Aligned: 852 rows
Threshold Bit Score: 27.9694
Threshold Setting Gi: 470365
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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ligand binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding surface [chemical binding site]
Evidence:
  • Comment:many but not all CTL domains bind ligands on this surface of the protein
  • Structure:1KCG_B, human Nkg2d homodimer bound with Ulbp3, contacts at 3.5 A.
    View structure with Cn3D
  • Structure:1P1Z_D, human Ly-49c bound with a MHC Class I ligand H-2kb, contacts at 3.5 A.
    View structure with Cn3D
  • Structure:1QO3_C, human Ly49a bound with MHC Class I ligand H-2dd, contacts at 3.5 A
    View structure with Cn3D
  • Structure:1YXK_B, human LOX-1 disulfide-linked dimer residues responsible for OxLDL binding defined by mutation analysis.
    View structure with Cn3D
  • Structure:1TDQ_B, rat aggrecan CLTD bound with fibronectin type III repeats 3-5 of rat tenascin-R, contacts at 3.5 A.
    View structure with Cn3D
  • Structure:1WMZ_D, Cucumaria echinata C-type lectin Cel-I bound with N-acetyl-D-galactosamine.(GalNAc), contacts at 3.5 A.
    View structure with Cn3D
  • Structure:1K9I_A, human DC-SIGN bound with Glcnac2man3, contacts at 3.5 A
    View structure with Cn3D
  • Comment:The carbohydrate cross-links two monomeric CTLDs in the DC-SIGN crystals.
  • Structure:1SL5_A, human DC-SIGN CTLD, bound with Lnfp Iii (Dextra L504), contacts at 3.5 A.
    View structure with Cn3D
  • Structure:1PWB_C, human lung surfactant protein D trimer, bound with maltose and calcium ions , contacts at 3.5A
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  • Structure:1KWY_A, rat mannose protein A trimer bound with Man-A13-Man, contacts at 3.5 A.
    View structure with Cn3D
  • Structure:1G1T_A, human E-selectin Lectin EGF domains bound with Slex and a calcium ion, contacts at 3.5 A
    View structure with Cn3D
  • Structure:1G1S_A, human P-selectin Lectin EGF domains bound with the glycoprotein, PSGL-1 peptide, contacts at 3.5
    View structure with Cn3D
  • Structure:2BRS_B, Homo sapiens, EMBP bound with heparin disaccharide, contacts at 3.5 A
    View structure with Cn3D
  • Structure:1TLG_A, Polyandrocarpa misakiensis, TC14 bound with a calcium ion and D-galactose.
    View structure with Cn3D
  • Structure:1IOD; complex between the Coagulation Factor X Binding Protein from snake venom and the Gla domain of Factor X
    View structure with Cn3D
  • Structure:1JZN_A, rattlesnake galactose-specific C-Type lectin, bound with galactose and calcium ions, contacts at 3.5 A.
    View structure with Cn3D

cd00037 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00037 is a member of the superfamily cl02432.
cd00037:CLECTcd03588:CLECT_CSPGscd03589:CLECT_CEL-1_likecd03590:CLECT_DC-SIGN_likecd03591:CLECT_collectin_likecd03592:CLECT_selectins_likecd03593:CLECT_NK_receptors_likecd03594:CLECT_REG-1_likecd03595:CLECT_chondrolectin_likecd03596:CLECT_tetranectin_likecd03597:CLECT_attractin_likecd03598:CLECT_EMBP_likecd03599:CLECT_DGCR2_likecd03600:CLECT_thrombomodulin_likecd03601:CLECT_TC14_likecd03602:CLECT_1cd03603:CLECT_VCBS28605624654876395819787201388730636853874431145182833958524472985663135199313351173133511925155109395828413309021334922430626451436826263056044170739717796055242074185256766245122738885233046364703651753282739596869175314991359231438782763979927175104291750742186563811583282386822173912814490351733879935175531821467019939580256175395783957955439583394395796643873961387396139591989175399723958819131746592175416147199205238750741753932617559816388021239592416395803846425419175066871756617838757023958776617536959719924781754046639583020175640987200144725395408395952741756595232697984316888331688873875786175071291754027839581670175652661755955639584662395830195050745976662247472165985839321638787903761983558081777248172907211511072148107175603761B6E  698113677998083375771031HYR A1KCG B1JSK B286290151YXK B1364970886450232371816501283684115907766709639910412208105862635105341351783739976737661636428893135618361011E8I A58490716328167019447133862364604831846019638502994305076669789027606128355128927845048797668753147605930766163682654177139288981028166958698131JA3 A1P1Z D1QO3 C465594086067827624976365612318519310369302674303026743221070944317899593984106162648227367634747216228684384274641093150749835684376271750982115218209557696759986661708396507565674925623647223668683683893875704175689613341390655243829665334761BYF A1TLG A10641067600987560098811615161925396647604995537201000072010000345761917200773472007736505126995072837672007734720892737210773626274367115951645645177505121681G1S A50751073683954641G1T A557755315596227816923223169232231692323816923225169232271692322516923227169232291692322972007734720435877201311772013117720131177201311772013117720720847207208472106137720720847207208472072084720720847207208472072084322643643226436432264364322643663247154032471540720030753247256887124836781661578613461886749366598025905980259086135736338631078880906088809060888090606792550578171192781711927817119278171192781711927817119278171192324776735750601387308660873086608731029947208698720087841261218911279318568318171372683119895555245488552454877870726055238154552381554928272760976874249555276097689729205117944697741608374160811992168828427193835066155241856552418575794234972957682017704921357549729601672974074906607312643566245806822458068462484338245809572202411421430364524211917173873571738798201297191952774521357617395911044161690420731422073144207314660418510250909123749684116768288910830092135726755239074910925921685117665313792464210933284861683630305596342168438899683585521WK1 A58539832965013387668417533685175336793881709175379213958042817555734395974423959744439580424395804261750664139588687720008181753368717533689395877671753791517537955278033884079260617506217175700591757077334146972395903133958333838373928683561644721144468438103507620935843043572062539683993521B08 A1PWB C1HUP  1KZE 21KWY A1KX1 F27361451R13 A1R14 A8903129215420996856638531885899768356570683565725453619583321587115955433417124507449904054842055250116664720521HTN  4538278756971206472082536842980920137707507939535159319568438079342230874722244812644919029151902921190291919029235381159351071940908744469126965192956462334551391255513912740908744469126965192956462334551391255513912731559111564623548724816924762680552441351433102172006269714211767214852172148521721485217214852172148521126730507323995073240147217439507323995073266368365898720929323052033150729858683615286837984631335113507538864720909772011952720553517205542572141577136170472116572175907454648182472097866836297047219279856626145073855034582300227604381260997208424172084241721435087208553372125759720828488623754139381147230595407883356835666034922430682626304723059468368669621149733875596395856593256619139585192395851943330008239143932BRS B119238766803867669335150747976472167294722691857646097200773472074955720961801755116017565466175544888623754619583847230595349224303492259462645143682626304723059468368669517448568356660323078174722636634922430507505376836866924293933958702175074173958870239588704750641475064143958701339583087395830883958374017559330719818403455588939582412175689613958631411139444837511647606097379075017538262175650583881867381760753174668534555878720006307715775239582434395870173958701839587019395870213958870239583740395878333958308739583088719872369506358720785454755118147551165720453807200785156756749720144041754357439587935719908611754469817544698720059097200591171981329719872362426677417560132720088673842276138422762507308216211497355633513720310661C3A A1UOS A1IOD A1JWI A3799339328296971SB2 A277342281UKM B251205147801567043481332430926704348518394422773422969175346195838472305956836462234922430682626306836866947230594483587850760588472188601GZ2 A4639675121541951463967501404298032450274507509981JZN C138767371UV0 A668633286237546195838369505568262630684169766693311517538770175387701753888826985835855397241DV8 A12613218426873583321545041809312613128374182472108041336551588853839472159012497642909917121815752076573331387929854312086375771173817642045360106524303746838312468393125684388491K9I A1SL4 A1SL5 A1528107947218445472275404722392947230199559633486836721268424003684328431T8D A37782432556481691EGI B5073240150732399507326635073239947217439683658986843640172010000720100007201000072010000720100007201000072125662720292941267306266392450732399507323995073240150732663472174396844002750732399720100007201000072110671126730507326636844002768356164483587850760588472188607201000072010000720292941TDQ B1298862506814475508251381090211257931WMY A1WMZ D21637389126127377321337208552933781087201505272010149721258416835779273959018173856302AFP A39904028628342765598626869720151863395684347952019623932469212741795102753067754784788861956202713782027137872009897720888661267305073239950732663472174396844002751744855076058847218860413938115595310447230595720100006843166972010000720100007201000072010000721106714072274586556132772044711784717540462126730507326634721743968365898517448550760588472188608623756841697641393811349224306826263047230594683686694723059512673050732399507323995073266338373928432112043211204321120432112086237541393811517448550760588472188604723059568364622175540101656642223822160475511773401369048476206721106711756506234013698340137007201000072010000720100007200819172085109720884787209491512673050732399507323995073240150732663507323996836589868440027349224306826263047230594683686694619583862988803472305954078833550760588472188603492243068262630683686693328486268362756345323077667218662659663626596637667218647213476472032316836275668400284559634196836275668359004683627566839997747213476684331156843311528605624654876395819787201388730636853874431145182833958524472985663135199313351173133511925155109395828413309021334922430626451436826263056044170739717796055242074185256766245122738885233046364703651753282739596869175314991359231438782763979927175104291750742186563811583282386822173912814490351733879935175531821467019939580256175395783957955439583394395796643873961387396139591989175399723958819131746592175416147199205238750741753932617559816388021239592416395803846425419175066871756617838757023958776617536959719924781754046639583020175640987200144725395408395952741756595232697984316888331688873875786175071291754027839581670175652661755955639584662395830195050745976662247472165985839321638787903761983558081777248172907211511072148107175603761B6E  698113677998083375771031HYR A1KCG B1JSK B286290151YXK B1364970886450232371816501283684115907766709639910412208105862635105341351783739976737661636428893135618361011E8I A58490716328167019447133862364604831846019638502994305076669789027606128355128927845048797668753147605930766163682654177139288981028166958698131JA3 A1P1Z D1QO3 C465594086067827624976365612318519310369302674303026743221070944317899593984106162648227367634747216228684384274641093150749835684376271750982115218209557696759986661708396507565674925623647223668683683893875704175689613341390655243829665334761BYF A1TLG A10641067600987560098811615161925396647604995537201000072010000345761917200773472007736505126995072837672007734720892737210773626274367115951645645177505121681G1S A50751073683954641G1T A557755315596227816923223169232231692323816923225169232271692322516923227169232291692322972007734720435877201311772013117720131177201311772013117720720847207208472106137720720847207208472072084720720847207208472072084322643643226436432264364322643663247154032471540720030753247256887124836781661578613461886749366598025905980259086135736338631078880906088809060888090606792550578171192781711927817119278171192781711927817119278171192324776735750601387308660873086608731029947208698720087841261218911279318568318171372683119895555245488552454877870726055238154552381554928272760976874249555276097689729205117944697741608374160811992168828427193835066155241856552418575794234972957682017704921357549729601672974074906607312643566245806822458068462484338245809572202411421430364524211917173873571738798201297191952774521357617395911044161690420731422073144207314660418510250909123749684116768288910830092135726755239074910925921685117665313792464210933284861683630305596342168438899683585521WK1 A58539832965013387668417533685175336793881709175379213958042817555734395974423959744439580424395804261750664139588687720008181753368717533689395877671753791517537955278033884079260617506217175700591757077334146972395903133958333838373928683561644721144468438103507620935843043572062539683993521B08 A1PWB C1HUP  1KZE 21KWY A1KX1 F27361451R13 A1R14 A8903129215420996856638531885899768356570683565725453619583321587115955433417124507449904054842055250116664720521HTN  4538278756971206472082536842980920137707507939535159319568438079342230874722244812644919029151902921190291919029235381159351071940908744469126965192956462334551391255513912740908744469126965192956462334551391255513912731559111564623548724816924762680552441351433102172006269714211767214852172148521721485217214852172148521126730507323995073240147217439507323995073266368365898720929323052033150729858683615286837984631335113507538864720909772011952720553517205542572141577136170472116572175907454648182472097866836297047219279856626145073855034582300227604381260997208424172084241721435087208553372125759720828488623754139381147230595407883356835666034922430682626304723059468368669621149733875596395856593256619139585192395851943330008239143932BRS B119238766803867669335150747976472167294722691857646097200773472074955720961801755116017565466175544888623754619583847230595349224303492259462645143682626304723059468368669517448568356660323078174722636634922430507505376836866924293933958702175074173958870239588704750641475064143958701339583087395830883958374017559330719818403455588939582412175689613958631411139444837511647606097379075017538262175650583881867381760753174668534555878720006307715775239582434395870173958701839587019395870213958870239583740395878333958308739583088719872369506358720785454755118147551165720453807200785156756749720144041754357439587935719908611754469817544698720059097200591171981329719872362426677417560132720088673842276138422762507308216211497355633513720310661C3A A1UOS A1IOD A1JWI A3799339328296971SB2 A277342281UKM B251205147801567043481332430926704348518394422773422969175346195838472305956836462234922430682626306836866947230594483587850760588472188601GZ2 A4639675121541951463967501404298032450274507509981JZN C138767371UV0 A668633286237546195838369505568262630684169766693311517538770175387701753888826985835855397241DV8 A12613218426873583321545041809312613128374182472108041336551588853839472159012497642909917121815752076573331387929854312086375771173817642045360106524303746838312468393125684388491K9I A1SL4 A1SL5 A1528107947218445472275404722392947230199559633486836721268424003684328431T8D A37782432556481691EGI B5073240150732399507326635073239947217439683658986843640172010000720100007201000072010000720100007201000072125662720292941267306266392450732399507323995073240150732663472174396844002750732399720100007201000072110671126730507326636844002768356164483587850760588472188607201000072010000720292941TDQ B1298862506814475508251381090211257931WMY A1WMZ D21637389126127377321337208552933781087201505272010149721258416835779273959018173856302AFP A399040286283427655986268697201518633956843479520196239324692127417951027530677547847888619562027137820271378720098977208886612673050732399507326634721743968440027517448550760588472188604139381155953104472305957201000068431669720100007201000072010000720100007211067140722745865561327720447117847175404621267305073266347217439683658985174485507605884721886086237568416976413938113492243068262630472305946836866947230595126730507323995073239950732663383739284321120432112043211204321120862375413938115174485507605884721886047230595683646221755401016566422238221604755117734013690484762067211067117565062340136983401370072010000720100007201000072008191720851097208847872094915126730507323995073239950732401507326635073239968365898684400273492243068262630472305946836866946195838629888034723059540788335507605884721886034922430682626306836866933284862683627563453230776672186626596636265966376672186472134764720323168362756684002845596341968362756683590046836275668399977472134766843311568433115
cd00037 Sequence Cluster
cd00037 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
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                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1B08_A        46 KIFKTAgf-----vKPFTEAQLLCTqag---gqLASPRSa----AENAALQqlvv-------akneAAFLSMtdsk---- 102
1KCG_B        17 NCYQFFde-----sKNWYESQASCMsqn---asLLKVYSk----EDQDLLKlv-----------ksYHWMGLvhip---- 69
gi 32264364   53 HEYYYSrdhfghilVNFTTARAYCRtlg---gdLVSINSk----AENDFVFslna-------ttfdRRWIGVqynt---- 114
gi 32264364  428 EYYYSRdyfp-sttFNFVEAMDWCDsig---ghLAYPDTr----AENEFIAsidp-------tmtnMRWLGVrynv---- 488
gi 32264364  618 HQYFYSkdfypdipLTFAQAQDWCEtmd---ahLVYTETk----AENDFVYsisp-------ipneLRWLGAvyns---- 679
gi 32264366  220 SYYAYVst-----sVTQPEAQTVCEadd---anLVSVDSl----AENSFVHglga--------pnqARWLGGivdysg-- 277
gi 39580384    8 LCISSTl-------ADCPAAWKTFLn------sEMEENTangceADWKFVNrpstsilaqvpessgSLWTGLrrtkkcig 74
gi 62663924  940 KVSENTdls---lgPMKHETNRVSTgifdkftsYSDTHSk----GSNTFVTyhmr-------dstfNAWTGLndvn---- 1001
gi 71159516   67 ECFYLSkv-----kLNWNQARQYCQgmq---gdLATPRNv---yALKSFVIdtaa--------evtEAWLGAtdqs---- 123
gi 72125759  565 SCYRLAws----dpVPYAQALQLCSel----gsFPFIPNv---rAEFDFVVeflgea----dlgiqTIWLGCddtn---- 625
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         #   # #        
1B08_A       103 --------tegkFTYPTGes--------------lvYSNWapgepn--------------ddggsEDCVEIFtn------ 140
1KCG_B        70 --------tngsWQWEDGsil-------------spNLLTiie-------------------mqkGDCALYAss------ 103
gi 32264364  115 --------sqgdFVNVDGylvddlittyytpcdpdtTCLWfkgepn--------------nafsdENCVQQGhlnpar-- 170
gi 32264364  489 --------sllnFATLDGntinsllaeyttclpsgaGCLWrrdepn--------------gitnnELCVQMGhpkg---- 542
gi 32264364  680 --------svdqYFFLDGtsi------------sglLAEYpvigcanggpgclwrndepngktngENCIQMGhpkg---- 735
gi 32264366  278 -------pddyaVTWADGssfd-----------vsmTDMWlpgqpng------------dgsclaQGQLTNNlpn----- 322
gi 39580384   75 qkitatctnltsFEWTDGsst------------gtdGFVFqagqpd--------------nknldQNCALFLasktptvv 128
gi 62663924 1002 --------sehtFLWTDGrg--------------vhYTNWgkgypggr---------rsslsyedVDCVVVIggns---- 1046
gi 71159516  124 --------segtWNWLDGrp---------------vASDWaggqpd--------------daggnEDCLDLRtkw----- 161
gi 72125759  626 --------mdgkFLCLDGkri-------------llHNPWwapgqp--------------dsyetENCLVLFlg------ 664
                        170       180       190
                 ....*....|....*....|....*....|....*..
Feature 1                 # ####             ###      
1B08_A       141 --------gKWNDRACg-----------EKRLVVCEF 158
1KCG_B       104 --------fKGYIENCs-----------TPNTYICMQ 121
gi 32264364  171 ----asnpgGWNDADCt-----------KDRAFVCEA 192
gi 32264364  543 -----gqvgNWNDAVCs-----------KRRFAVCEI 563
gi 32264364  736 -----gqpaSWNDAVCt-----------KFRFAVCER 756
gi 32264366  323 ------vssLWNDVPCt-----------TSLPFVCEK 342
gi 39580384  129 ankgtyyaaSYEDTGCevgefseahlprKILGHVCGK 165
gi 62663924 1047 -----reagTWMDSTCd-----------SKQGYICQT 1067
gi 71159516  162 -------hpTLNDYQCg-----------VAQHFVCQY 180
gi 72125759  665 -------amNLHDYPCt----------lANPNTLCER 684

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