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ZNF737 zinc finger protein 737 [ Homo sapiens (human) ]

Gene ID: 100129842, updated on 17-Aug-2024

Summary

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Official Symbol
ZNF737provided by HGNC
Official Full Name
zinc finger protein 737provided by HGNC
Primary source
HGNC:HGNC:32468
See related
Ensembl:ENSG00000237440 MIM:603984; AllianceGenome:HGNC:32468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF102
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thyroid (RPKM 7.4), ovary (RPKM 4.3) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (20530276..20565781, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (20667808..20703634, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (20720798..20748587, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 826, pseudogene Neighboring gene uncharacterized LOC124904663 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20605449-20606295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14378 Neighboring gene BCL2 interacting protein 3 pseudogene 22 Neighboring gene uncharacterized LOC105372317 Neighboring gene BCL2 interacting protein 3 pseudogene 23 Neighboring gene uncharacterized LOC105372316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14380 Neighboring gene vomeronasal 1 receptor 78 pseudogene Neighboring gene uncharacterized LOC105372318 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:20796649-20796907

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
  2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 737
Names
zinc finger protein 102 (Y3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159293.2 → NP_001152765.1  zinc finger protein 737

    See identical proteins and their annotated locations for NP_001152765.1

    Status: VALIDATED

    Source sequence(s)
    AC008554, AI857360, BC015765, DA043454
    Consensus CDS
    CCDS54238.1
    UniProtKB/Swiss-Prot
    C9JHM3, O75373
    Related
    ENSP00000395733.3, ENST00000427401.9
    Conserved Domains (5) summary
    smart00349
    Location:4 → 62
    KRAB; krueppel associated box
    COG5048
    Location:143 → 529
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 43
    KRAB; KRAB box
    pfam13465
    Location:383 → 408
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    20530276..20565781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722597.5 → XP_006722660.1  zinc finger protein 737 isoform X2

    See identical proteins and their annotated locations for XP_006722660.1

    Conserved Domains (5) summary
    smart00349
    Location:4 → 62
    KRAB; krueppel associated box
    COG5048
    Location:143 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 43
    KRAB; KRAB box
    pfam13465
    Location:383 → 408
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005259697.5 → XP_005259754.1  zinc finger protein 737 isoform X1

    See identical proteins and their annotated locations for XP_005259754.1

    Conserved Domains (5) summary
    smart00349
    Location:4 → 62
    KRAB; krueppel associated box
    COG5048
    Location:143 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 43
    KRAB; KRAB box
    pfam13465
    Location:383 → 408
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047438008.1 → XP_047293964.1  zinc finger protein 737 isoform X5

  4. XM_017026117.3 → XP_016881606.1  zinc finger protein 737 isoform X6

  5. XM_011527598.4 → XP_011525900.1  zinc finger protein 737 isoform X1

    See identical proteins and their annotated locations for XP_011525900.1

    Conserved Domains (5) summary
    smart00349
    Location:4 → 62
    KRAB; krueppel associated box
    COG5048
    Location:143 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 43
    KRAB; KRAB box
    pfam13465
    Location:383 → 408
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011527599.4 → XP_011525901.1  zinc finger protein 737 isoform X2

    See identical proteins and their annotated locations for XP_011525901.1

    Conserved Domains (5) summary
    smart00349
    Location:4 → 62
    KRAB; krueppel associated box
    COG5048
    Location:143 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 43
    KRAB; KRAB box
    pfam13465
    Location:383 → 408
    zf-H2C2_2; Zinc-finger double domain

  7. XM_047438007.1 → XP_047293963.1  zinc finger protein 737 isoform X4

  8. XM_047438006.1 → XP_047293962.1  zinc finger protein 737 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    20667808..20703634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319452.1 → XP_054175427.1  zinc finger protein 737 isoform X2

  2. XM_054319450.1 → XP_054175425.1  zinc finger protein 737 isoform X1

  3. XM_054319455.1 → XP_054175430.1  zinc finger protein 737 isoform X5

  4. XM_054319456.1 → XP_054175431.1  zinc finger protein 737 isoform X6

  5. XM_054319449.1 → XP_054175424.1  zinc finger protein 737 isoform X1

  6. XM_054319451.1 → XP_054175426.1  zinc finger protein 737 isoform X2

  7. XM_054319454.1 → XP_054175429.1  zinc finger protein 737 isoform X4

  8. XM_054319453.1 → XP_054175428.1  zinc finger protein 737 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75373.3 GenPept UniProtKB/Swiss-Prot:O75373

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