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DHX8 DEAH-box helicase 8 [ Monodelphis domestica (gray short-tailed opossum) ]

Gene ID: 100010159, updated on 8-May-2024

Summary

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Gene symbol
DHX8
Gene description
DEAH-box helicase 8
See related
EnsemblRapid:ENSMODG00000015181
Gene type
protein coding
RefSeq status
MODEL
Organism
Monodelphis domestica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 2 NC_077228.1 (193088101..193116780, complement)
103 previous assembly MonDom5 (GCF_000002295.2) 2 NC_008802.1 (192879661..192908326, complement)

Chromosome 2 - NC_077228.1Genomic Context describing neighboring genes Neighboring gene mesenchyme homeobox 1 Neighboring gene ETS variant transcription factor 4 Neighboring gene uncharacterized LOC103105022 Neighboring gene ADP ribosylation factor like GTPase 4D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in spliceosomal complex disassembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular anatomical structure IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent RNA helicase DHX8
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mMonDom1.pri

Genomic

  1. NC_077228.1 Reference mMonDom1.pri

    Range
    193088101..193116780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001362968.4 → XP_001363005.1  ATP-dependent RNA helicase DHX8

    UniProtKB/TrEMBL
    A0A5F8GDQ9, F7BWD9
    Related
    ENSMODP00000018968.3, ENSMODT00000019310.5
    Conserved Domains (6) summary
    smart00487
    Location:537 → 722
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:940 → 1022
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:558 → 696
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:721 → 878
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd05684
    Location:241 → 319
    S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...
    pfam07717
    Location:1056 → 1155
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. XR_462039.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
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