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Dhx8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 [ Mus musculus (house mouse) ]

Gene ID: 217207, updated on 12-Aug-2018

Summary

Official Symbol
Dhx8provided by MGI
Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 8provided by MGI
Primary source
MGI:MGI:1306823
See related
Ensembl:ENSMUSG00000034931 Vega:OTTMUSG00000002937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx8; mDEAH6; mKIAA4096
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.1), thymus adult (RPKM 9.5) and 28 other tissues See more
Orthologs

Genomic context

See Dhx8 in Genome Data Viewer
Location:
11; 11 D
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101732956..101767358)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101594270..101628672)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 4D Neighboring gene predicted gene, 39391 Neighboring gene ets variant 4 Neighboring gene predicted gene, 39392

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

General gene information

Homology

Clone Names

  • KIAA4096, MGC31290

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent 3'-5' RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
spliceosomal complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX8
Names
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 8
DEAH box protein 8
RNA helicase
NP_659080.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144831.2NP_659080.2  ATP-dependent RNA helicase DHX8

    See identical proteins and their annotated locations for NP_659080.2

    Status: VALIDATED

    Source sequence(s)
    BB654249, BC065064
    Consensus CDS
    CCDS25479.1
    UniProtKB/Swiss-Prot
    A2A4P0
    Related
    ENSMUSP00000037251.7, OTTMUSP00000002846, ENSMUST00000039152.13, OTTMUST00000006027
    Conserved Domains (6) summary
    smart00487
    Location:585770
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:9881070
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:606744
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:769926
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd05684
    Location:289367
    S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...
    pfam07717
    Location:11041203
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    101732956..101767358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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