2XAU


Conserved Protein Domain Family
OB_NTP_bind

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pfam07717: OB_NTP_bind (this model, PSSM-Id:285018 is obsolete and has been replaced by 336780)
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Oligonucleotide/oligosaccharide-binding (OB)-fold
This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Statistics
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PSSM-Id: 285018
View PSSM: pfam07717
Aligned: 58 rows
Threshold Bit Score: 55.4176
Threshold Setting Gi: 75027634
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XAU_B        621 SQLERLM-----------------------------NRY---NLELnttd------------------------------ 638
gi 74644973  1171 AQYYSIL-----------------------------KDVgflPMDYkvgsis---------------------------- 1193
gi 74582920  1127 NELSEAA-----------------------------QLLeltTKKLtgnfd----------------------------- 1148
gi 75027634   678 QQFQRILescgmvvasdsdsq-ltsaeratrhgelrQLKamkRRQRfeqprqrkllkqsagrvaedeeeqeeaqg----- 751
gi 75013540  1279 KQLLSTI-----------------------------NDLgiiNAQLrdgfvnn--------------------------- 1302
gi 12643928   829 seivssL-----------------------------RAAnliHSRGklsmnn---------------------------- 851
gi 47116751   687 RQFKELLedhgllsgaqvvap-gdsysrlqqrrerrALHqlkRQHEegggrrrkvlrlqedgcssdeedrkgstsqra-d 764
gi 808357698  428 aQYRQILedaglvekasaaetgeddsrqrridqgekRKLfdlKKSQrnndrrqkvlnankhfdkiledkeeedleaekdp 507
gi 727593535   97 SQLESEL-----------------------------KRHgiiPNDIsscs------------------------------ 117
gi 15221547   890 rKLQGEL-----------------------------NRHgviPSSSsncs------------------------------ 910
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XAU_B        639 --------------------------yespKYFDNIRKALASGFFMQVA------KKR------------SGaKGYITV- 673
gi 74644973  1194 ------------------------dlnrneRNFDILRAILTGAFYPHIArv---qLPDvkylstssgaveKD-PEAKMIk 1245
gi 74582920  1149 --------------------------wystENLTVLSTLIAAALSPNVVkc---vYPDkkfvasfsgsleME-QEARLTk 1198
gi 75027634   752 -ddmrdvdfrlrfdprqlallerssrldrhSVVVLLKLLLGSGFYPQLA------ISDefny-----ckgGG-QQFFHT- 817
gi 75013540  1303 -----------------------sffnensNNLDIIRAIICSGLFPNIA------RQR------------KK-REFKTL- 1339
gi 12643928   852 -------------------------lnqmsCNWHMVKAALTGGMYPNIY------AVDt-----------RK-SSLKSA- 887
gi 47116751   765 svdiqdvkfklrhnleqlqaaassaqdltrDQLALLKLVLGRGLYPQLA------VPDafns-----grkDS-DQIFHT- 831
gi 808357698  508 lkadvktvefllshkqrdvenirkthkisrKTAEVVRVIIAAGLYPNFS------ILDpvnk-----ygyGQ-EMFTHT- 574
gi 727593535  118 ---------------------------qnsRDPGILRAVLSVGLYPMVGrlc-paFGN------------NR-RTIVET- 155
gi 15221547   911 ---------------------------lnaHDPGILRAVIAVGLYPMLGrmcplsKNR------------TR-SVIETI- 949
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XAU_B        674 -------------------------------KDNQ-DVLIHPSTVL------------GHDAE----------------- 692
gi 74644973  1246 ywirseeyqdkleeyktkisqetqkvdledlPLPAtRAFIHPSSVLfstn----svnlEDAKLlsevdgpisrqskiptv 1321
gi 74582920  1199 f-----------------------------yDQNNqRLFIHPSSTMf-----------VNSPNasr-------------- 1224
gi 75027634   818 -------------------------------RLKP-FVLQHPNSQFakhfellkltesDLLPKpdfytpkl------pls 859
gi 75013540  1340 -------------------------------SE---NTFLHPSSIVy-----------NLFQElnp-------------- 1360
gi 12643928   888 -------------------------------FSG--NVSMHPNTVLr-----------DFLEP----------------- 906
gi 47116751   832 -------------------------------QAKQ-GTVLHPTCVFanspevlhtqgqEASGQegsqdgrd------qms 873
gi 808357698  575 -------------------------------RLKP-FTQIHPNSSIa-----------QYHPEtidprqgs-----dgfs 606
gi 727593535  156 -------------------------------ASGA-KVRVHSLSNNf-----------NLSSKkyd-------------- 178
gi 15221547   950 --------------------------------AGA-KVRVPSLSNNv-----------DMSSTkfd-------------- 971
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
2XAU_B        693 ----WVIYNEFVLT-------SK-NYIRTVTSV-RPEWLIEI-APAY 725
gi 74644973  1322 vkypFVLFTTSQVT-------NK-LYLRDLTPT-TTLSLLLF-GGAI 1358
gi 74582920  1225 --ctFVAYEQKVET-------TK-PFLRNCTPI-NTYGMILLgANDI 1260
gi 75027634   860 krhqLLCYQSLLET-------AK-PYLINCIRLpAAQTLLLF-SFAI 897
gi 75013540  1361 -kenWVIFEEKFKT-------KL-TFIKTITRI-PEISLLLFgSTPI 1397
gi 12643928   907 ----LNISAQSFRTpwivcnrQK-SHIVYATLV-VPLAVAMF-SGHp 946
gi 47116751   874 ckhqLLAFVSLLET-------NK-PYLVNCVRIpALQSLLLF-SRSI 911
gi 808357698  607 rlhqIPFYGLLLET-------TK-PYICNVMPV-PAVYTLLV-AQKI 643
gi 727593535  179 --esLVVFDEITRG-------DGgMHIRNCTVV-RDLPLLLV-STei 214
gi 15221547   972 --eaLIVFDEITRG-------DWgVVIRSCTVL-PTIPVLLF-SREI 1007
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