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    Zfp202 zinc finger protein 202 [ Mus musculus (house mouse) ]

    Gene ID: 80902, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Zfp202provided by MGI
    Official Full Name
    zinc finger protein 202provided by MGI
    Primary source
    MGI:MGI:1933401
    See related
    Ensembl:ENSMUSG00000025602 AllianceGenome:MGI:1933401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf202; C130037E22Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome; nuclear body; and nucleolus. Is expressed in allantois; foregut diverticulum; genitourinary system; and neural fold. Orthologous to human ZNF202 (zinc finger protein 202). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 1.6), CNS E14 (RPKM 1.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.1; 9 21.42 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40103612..40124900)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40192316..40213604)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Fcf1 pseudogene Neighboring gene olfactory receptor family 6 subfamily X member 1 Neighboring gene STARR-seq mESC enhancer starr_23849 Neighboring gene STARR-seq mESC enhancer starr_23851 Neighboring gene sodium channel, voltage-gated, type III, beta Neighboring gene GRAM domain containing 1B Neighboring gene RIKEN cDNA 1700110K17 gene Neighboring gene STARR-seq mESC enhancer starr_23853

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice. Vrins CL, et al. PLoS One, 2013. PMID 23469003, Free PMC Article
    2. SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation. Patterson ES, et al. Physiol Genomics, 2008 Aug 15. PMID 18523156
    3. Identification of SCAN dimerization domains in four gene families. Honer C, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342224
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 202
    Names
    zinc finger 202

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359464.1 → NP_001346393.1  zinc finger protein 202 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC135353, AC136021
      Consensus CDS
      CCDS90536.1
      UniProtKB/TrEMBL
      E9Q2D3
      Related
      ENSMUSP00000132131.2, ENSMUST00000168832.2
      Conserved Domains (2) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      cl02581
      Location:237 → 277
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. NM_030713.2 → NP_109638.2  zinc finger protein 202 isoform 1

      See identical proteins and their annotated locations for NP_109638.2

      Status: VALIDATED

      Source sequence(s)
      AC135353, AC136021, BC049772
      Consensus CDS
      CCDS23079.1
      UniProtKB/TrEMBL
      Q8C879
      Related
      ENSMUSP00000026693.8, ENSMUST00000026693.14
      Conserved Domains (4) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:332 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393 → 413
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_153114.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC135353, AC136021
      Related
      ENSMUST00000168691.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      40103612..40124900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242629.4 → XP_011240931.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_011240931.1

      UniProtKB/TrEMBL
      Q8C879
      Conserved Domains (4) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:332 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393 → 413
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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