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ZNF202 zinc finger protein 202 [ Homo sapiens (human) ]

Gene ID: 7753, updated on 1-Jun-2020

Summary

Official Symbol
ZNF202provided by HGNC
Official Full Name
zinc finger protein 202provided by HGNC
Primary source
HGNC:HGNC:12994
See related
Ensembl:ENSG00000166261 MIM:603430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN42; ZKSCAN10
Expression
Ubiquitous expression in testis (RPKM 4.3), ovary (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF202 in Genome Data Viewer
Location:
11q24.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (123723914..123741675, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (123594997..123612383, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1B Neighboring gene splicing factor 3a, subunit 3 pseudogene 2 Neighboring gene uncharacterized LOC105369543 Neighboring gene sodium voltage-gated channel beta subunit 3 Neighboring gene RNA, U1 small nuclear 21, pseudogene Neighboring gene olfactory receptor family 6 subfamily X member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger protein 202 (ZNF202) at amino acid residues 68-69 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 202
Names
zinc finger protein with KRAB and SCAN domains 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301779.2NP_001288708.1  zinc finger protein 202 isoform 1

    See identical proteins and their annotated locations for NP_001288708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK226047, AL162031, AP000868, BC013382, DA770117, H89560, H89561
    Consensus CDS
    CCDS8443.1
    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Related
    ENSP00000337724.4, ENST00000336139.8
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001301780.2NP_001288709.1  zinc finger protein 202 isoform 1

    See identical proteins and their annotated locations for NP_001288709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK023751, AL162031, AP000868, BC013382, DA770117, H89560, H89561, HY056142
    Consensus CDS
    CCDS8443.1
    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3, B3KN61
    Related
    ENSP00000433881.1, ENST00000529691.1
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001301819.1NP_001288748.1  zinc finger protein 202 isoform 2

    See identical proteins and their annotated locations for NP_001288748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF027218, AL162031, BC013382, DA770117, H89560, H89561
    UniProtKB/Swiss-Prot
    O95125
    Conserved Domains (3) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    COG5048
    Location:367424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343363
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_003455.4NP_003446.2  zinc finger protein 202 isoform 1

    See identical proteins and their annotated locations for NP_003446.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL162031, AP000868, BC013382, DA770117, H89560, H89561, HY056142
    Consensus CDS
    CCDS8443.1
    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Related
    ENSP00000432504.1, ENST00000530393.6
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    123723914..123741675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271659.1XP_005271716.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_005271716.1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005271661.1XP_005271718.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_005271718.1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005271660.1XP_005271717.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_005271717.1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011542972.1XP_011541274.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_011541274.1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011542975.1XP_011541277.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_011541277.1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011542973.1XP_011541275.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_011541275.1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017018268.2XP_016873757.1  zinc finger protein 202 isoform X1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  8. XM_006718901.2XP_006718964.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_006718964.1

    UniProtKB/Swiss-Prot
    O95125
    UniProtKB/TrEMBL
    A0A024R3M3
    Conserved Domains (8) summary
    smart00431
    Location:43153
    SCAN; leucine rich region
    smart00349
    Location:237297
    KRAB; krueppel associated box
    COG5048
    Location:397644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:567587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593615
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:237277
    KRAB; KRAB box
    pfam02023
    Location:43130
    SCAN; SCAN domain
    pfam13465
    Location:607632
    zf-H2C2_2; Zinc-finger double domain
  9. XM_005271664.2XP_005271721.1  zinc finger protein 202 isoform X2

    See identical proteins and their annotated locations for XP_005271721.1

    UniProtKB/Swiss-Prot
    O95125
    Conserved Domains (3) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    COG5048
    Location:367424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343363
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_024448682.1XP_024304450.1  zinc finger protein 202 isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    COG5048
    Location:367424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343363
    ZF_C2H2; C2H2 Zn finger [structural motif]
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