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    OPRK1 opioid receptor kappa 1 [ Homo sapiens (human) ]

    Gene ID: 4986, updated on 17-Jun-2019

    Summary

    Official Symbol
    OPRK1provided by HGNC
    Official Full Name
    opioid receptor kappa 1provided by HGNC
    Primary source
    HGNC:HGNC:8154
    See related
    Ensembl:ENSG00000082556 MIM:165196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOR; OPRK; KOR-1; K-OR-1
    Summary
    This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues See more
    Orthologs

    Genomic context

    See OPRK1 in Genome Data Viewer
    Location:
    8q11.23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (53225716..53251697, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54138276..54164257, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene uncharacterized LOC105375836 Neighboring gene EI24 pseudogene 5 Neighboring gene DNA polymerase epsilon 2, accessory subunit pseudogene Neighboring gene uncharacterized LOC100507516

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Kappa-opioid receptor (KOR) agonist treatment of CD4(+) lymphocytes inhibits HIV-1 envelope gp120/41-mediated membrane fusion via downregulation of CXCR4 PubMed
    Tat tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
      MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dynorphin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dynorphin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dynorphin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    opioid receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor serine/threonine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    conditioned place preference IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of luteinizing hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    opioid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of locomotion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of saliva secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    response to acrylamide IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    response to radiation IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception TAS
    Traceable Author Statement
    more info
    PubMed 
    sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sensory perception of temperature stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integral component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    kappa-type opioid receptor
    Names
    Opiate receptor, kappa-1
    kappa opioid receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000912.5NP_000903.2  kappa-type opioid receptor isoform 1

      See identical proteins and their annotated locations for NP_000903.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt . This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      AK023198, AY466378, BC099912, DA264471, U17298
      Consensus CDS
      CCDS6152.1
      UniProtKB/Swiss-Prot
      P41145
      Related
      ENSP00000265572.3, ENST00000265572.8
      Conserved Domains (1) summary
      cd15091
      Location:60341
      7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001282904.1NP_001269833.1  kappa-type opioid receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon in the mid-region, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC009646, AK310407, BF061371
      Consensus CDS
      CCDS64895.1
      UniProtKB/Swiss-Prot
      P41145
      Related
      ENSP00000483000.1, ENST00000612786.4
      Conserved Domains (1) summary
      pfam00001
      Location:1241
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_001318497.2NP_001305426.1  kappa-type opioid receptor isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AK023198, AY466378, BC099912, DA264471, U17298
      UniProtKB/Swiss-Prot
      P41145
      Conserved Domains (2) summary
      pfam00001
      Location:76330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:71271
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      53225716..53251697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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