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Oprk1 opioid receptor, kappa 1 [ Mus musculus (house mouse) ]

Gene ID: 18387, updated on 9-Dec-2024

Summary

Official Symbol
Oprk1provided by MGI
Official Full Name
opioid receptor, kappa 1provided by MGI
Primary source
MGI:MGI:97439
See related
Ensembl:ENSMUSG00000025905 AllianceGenome:MGI:97439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
Summary
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in frontal lobe adult (RPKM 1.1), cortex adult (RPKM 0.9) and 8 other tissues See more
Orthologs
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Genomic context

See Oprk1 in Genome Data Viewer
Location:
1 A1; 1 1.89 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (5658673..5676357)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (5588450..5606134)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide pseudogene Neighboring gene proteasome (prosome, macropain) subunit, alpha type 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00061 Neighboring gene STARR-seq mESC enhancer starr_00062 Neighboring gene STARR-seq mESC enhancer starr_00063 Neighboring gene STARR-seq mESC enhancer starr_00064 Neighboring gene STARR-seq mESC enhancer starr_00065 Neighboring gene STARR-seq mESC enhancer starr_00066 Neighboring gene STARR-seq mESC enhancer starr_00067 Neighboring gene STARR-seq mESC enhancer starr_00068 Neighboring gene STARR-seq mESC enhancer starr_00069 Neighboring gene STARR-seq mESC enhancer starr_00070 Neighboring gene neuropeptides B/W receptor 1 Neighboring gene STARR-seq mESC enhancer starr_00071 Neighboring gene STARR-seq mESC enhancer starr_00072 Neighboring gene COP9 (constitutive photomorphogenic) homolog, subunit 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (12)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC151172

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled opioid receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled opioid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled opioid receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled opioid receptor activity TAS
Traceable Author Statement
more info
 
enables dynorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynorphin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables dynorphin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in conditioned place preference ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maternal behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of saliva secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of temperature stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kappa-type opioid receptor
Names
opioid receptor, kappa 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204371.2NP_001191300.1  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_001191300.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC124029
    Consensus CDS
    CCDS14809.1
    UniProtKB/Swiss-Prot
    P33534
    UniProtKB/TrEMBL
    Q14AL5
    Related
    ENSMUSP00000027038.5, ENSMUST00000027038.11
    Conserved Domains (2) summary
    pfam00001
    Location:76330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor
  2. NM_001318735.1NP_001305664.1  kappa-type opioid receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AC124029, AK136866, BB079154, L11065, S81111
    Consensus CDS
    CCDS87811.1
    UniProtKB/TrEMBL
    A0A5F8MP90
    Conserved Domains (2) summary
    pfam00001
    Location:76330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor
  3. NM_011011.3NP_035141.1  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_035141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' non-coding region and has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC124029
    Consensus CDS
    CCDS14809.1
    UniProtKB/Swiss-Prot
    P33534
    UniProtKB/TrEMBL
    Q14AL5
    Related
    ENSMUSP00000125105.2, ENSMUST00000160777.8
    Conserved Domains (2) summary
    pfam00001
    Location:76330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    5658673..5676357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495470.1XP_006495533.1  kappa-type opioid receptor isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:531
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1252
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily