Oprk1 opioid receptor, kappa 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oprk1provided by MGI
Official Full Name: opioid receptor, kappa 1provided by MGI
Primary source: MGI:MGI:97439
See related: Ensembl:ENSMUSG00000025905 AllianceGenome:MGI:97439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
Summary: This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression: Biased expression in frontal lobe adult (RPKM 1.1), cortex adult (RPKM 0.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A1; 1 1.89 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (5658673..5676357)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (5588450..5606134)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

kappa-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-kappaB pathway.
Title: κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway.
Kappa Opioid Receptors Reduce Serotonin Uptake and Escitalopram Efficacy in the Mouse Substantia Nigra Pars Reticulata.
Title: Kappa Opioid Receptors Reduce Serotonin Uptake and Escitalopram Efficacy in the Mouse Substantia Nigra Pars Reticulata.
Conditional Deletion of KOR (Oprk1) in Kisspeptin Cells Does Not Alter LH Pulses, Puberty, or Fertility in Mice.
Title: Conditional Deletion of KOR (Oprk1) in Kisspeptin Cells Does Not Alter LH Pulses, Puberty, or Fertility in Mice.
Amygdalar kappa-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.
Title: Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Title: Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Kappa opioid receptor controls neural stem cell differentiation via a miR-7a/Pax6 dependent pathway.
Title: Kappa opioid receptor controls neural stem cell differentiation via a miR-7a/Pax6 dependent pathway.
Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons.
Title: Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons.
Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling.
Title: Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling.
kappa-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance.
Title: κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance.
Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice.
Title: Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491351

Oprk1 (e-PCR), detects polymorphism
- UniSTS:144086

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled opioid receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled opioid receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled opioid receptor activity	TAS Traceable Author Statement more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables dynorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables dynorphin receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled opioid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in conditioned place preference	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eating behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of saliva secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of temperature stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kappa-type opioid receptor

Names: opioid receptor, kappa 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204371.1 → NP_001191300.1 kappa-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_001191300.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AC124029, AK136866, BB079154, L11065, S81111

Consensus CDS

CCDS14809.1

UniProtKB/Swiss-Prot

P33534

UniProtKB/TrEMBL

Q14AL5

Related

ENSMUSP00000027038.5, ENSMUST00000027038.11

Conserved Domains (2) summary

pfam00001
Location:76 → 330

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:70 → 312

7tm_4; Olfactory receptor
NM_001318735.1 → NP_001305664.1 kappa-type opioid receptor isoform 1x

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.

Source sequence(s)

AC124029, AK136866, BB079154, L11065, S81111

Consensus CDS

CCDS87811.1

UniProtKB/TrEMBL

A0A5F8MP90

Conserved Domains (2) summary

pfam00001
Location:76 → 330

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:70 → 312

7tm_4; Olfactory receptor
NM_011011.2 → NP_035141.1 kappa-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_035141.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' non-coding region and has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AC124029, AK136866, BB079154, L11065

Consensus CDS

CCDS14809.1

UniProtKB/Swiss-Prot

P33534

UniProtKB/TrEMBL

Q14AL5

Related

ENSMUSP00000125105.2, ENSMUST00000160777.8

Conserved Domains (2) summary

pfam00001
Location:76 → 330

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:70 → 312

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

5658673..5676357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495470.1 → XP_006495533.1 kappa-type opioid receptor isoform X1

Conserved Domains (2) summary

cd14964
Location:5 → 31

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:1 → 252

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily