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    CHUK component of inhibitor of nuclear factor kappa B kinase complex [ Homo sapiens (human) ]

    Gene ID: 1147, updated on 17-Jun-2024

    Summary

    Official Symbol
    CHUKprovided by HGNC
    Official Full Name
    component of inhibitor of nuclear factor kappa B kinase complexprovided by HGNC
    Primary source
    HGNC:HGNC:1974
    See related
    Ensembl:ENSG00000213341 MIM:600664; AllianceGenome:HGNC:1974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPS2; IKK1; IKKA; IKBKA; IKK-1; TCF16; NFKBIKA; IKK-alpha
    Summary
    This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 4.9), bone marrow (RPKM 4.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CHUK in Genome Data Viewer
    Location:
    10q24.31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (100186319..100229596, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (101070354..101113853, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101948057..101989353, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:101907932-101909131 Neighboring gene signal peptidase complex subunit 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2702 Neighboring gene ER lipid raft associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3884 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:101990400-101990662 Neighboring gene CHUK divergent transcript Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene small nucleolar RNA, H/ACA box 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Bartsocas-Papas syndrome 2
    MedGen: C5543445 OMIM: 619339 GeneReviews: Not available
    Compare labs
    Cocoon syndrome
    MedGen: C3150891 OMIM: 613630 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) PubMed
    Nef nef HIV-1 Nef induces phosphorylation of CHUK (IKKalpha) PubMed
    nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
    nef HIV-1 Nef induces phosphorylation of IKKalpha in M2-type macrophages PubMed
    nef The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages PubMed
    nef HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members PubMed
    Tat tat HIV-1 Tat induces phosphorylation of CHUK (IKKalpha) in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat induces phosphorylation of IKK-alpha/IKK-beta in human astroglioma cells PubMed
    tat HIV-1 Tat induces phosphorylation of IKK in HeLa-CD4-long terminal repeat (LTR)-beta-gal (MAGI) cells PubMed
    tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
    tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
    Vpr vpr HIV-1 Vpr requires CHUK (IKKa) or IKBKB (IKKb) to induce G2/M arrest in HeLa cells as shown through siRNA knockdown of CHUK (IKKa) or IKBKB (IKKb) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables IkappaB kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IkappaB kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in I-kappaB phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to acetate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cholecystokinin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of IkappaB kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of IkappaB kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of IkappaB kinase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit alpha
    Names
    I-kappa-B kinase 1
    I-kappa-B kinase-alpha
    IKK-a kinase
    IkB kinase alpha subunit
    Nuclear factor NFkappaB inhibitor kinase alpha
    conserved helix-loop-helix ubiquitous kinase
    transcription factor 16
    NP_001269.3
    NP_001307857.1
    XP_016871101.1
    XP_047280496.1
    XP_047280497.1
    XP_047280498.1
    XP_047280499.1
    XP_054220630.1
    XP_054220631.1
    XP_054220632.1
    XP_054220633.1
    XP_054220634.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028023.2 RefSeqGene

      Range
      5000..46296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278.5NP_001269.3  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_001269.3

      Status: REVIEWED

      Source sequence(s)
      AF080157, AI829429, BC034796, BM800404, DA405845
      Consensus CDS
      CCDS7488.1
      UniProtKB/Swiss-Prot
      O14666, O15111, Q13132, Q5W0I4, Q92467
      UniProtKB/TrEMBL
      Q562E6
      Related
      ENSP00000359424.6, ENST00000370397.8
      Conserved Domains (2) summary
      cd14039
      Location:21309
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
      pfam12179
      Location:709743
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
    2. NM_001320928.2NP_001307857.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2

      Status: REVIEWED

      Source sequence(s)
      AI829429, AL138921, DA405845
      UniProtKB/TrEMBL
      Q59GT1
      Conserved Domains (2) summary
      smart00220
      Location:15298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14039
      Location:21309
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      100186319..100229596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424542.1XP_047280498.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3

      UniProtKB/TrEMBL
      Q59GT1
    2. XM_047424540.1XP_047280496.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

      UniProtKB/TrEMBL
      Q562E6
    3. XM_047424541.1XP_047280497.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2

      UniProtKB/TrEMBL
      Q59GT1
    4. XM_017015612.2XP_016871101.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X4

    5. XM_047424543.1XP_047280499.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      101070354..101113853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364655.1XP_054220630.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

      UniProtKB/TrEMBL
      Q562E6
    2. XM_054364657.1XP_054220632.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3

      UniProtKB/TrEMBL
      Q59GT1
    3. XM_054364656.1XP_054220631.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2

      UniProtKB/TrEMBL
      Q59GT1
    4. XM_054364658.1XP_054220633.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X4

    5. XM_054364659.1XP_054220634.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X5