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Chuk conserved helix-loop-helix ubiquitous kinase [ Mus musculus (house mouse) ]

Gene ID: 12675, updated on 8-Jul-2018
Official Symbol
Chukprovided by MGI
Official Full Name
conserved helix-loop-helix ubiquitous kinaseprovided by MGI
Primary source
MGI:MGI:99484
See related
Ensembl:ENSMUSG00000025199 Vega:OTTMUSG00000029724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IKK1; Ikka; Chuk1; Fbx24; IKBKA; Fbxo24; NFKBIKA; AI256658; IKK alpha
Expression
Ubiquitous expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 11.6) and 28 other tissues See more
Orthologs
See Chuk in Genome Data Viewer
Location:
19 C3; 19 36.71 cM
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (44073334..44107509, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44147824..44181967, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23 Neighboring gene ER lipid raft associated 1 Neighboring gene uracil DNA glycosylase pseudogene Neighboring gene CWF19-like 1, cell cycle control (S. pombe) Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC25325

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CONTRIBUTES_TO IkappaB kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to IkappaB kinase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
I-kappaB phosphorylation TAS
Traceable Author Statement
more info
PubMed 
NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactation IGI
Inferred from Genetic Interaction
more info
PubMed 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interferon-alpha secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-alpha secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit alpha
Names
I kappa B kinase 1
I-kappa-B kinase alpha
IkappaB kinase alpha
nuclear factor NF-kappa-B inhibitor kinase alpha
NP_001155882.1
NP_031726.2
XP_011245431.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162410.1NP_001155882.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC124693, AK035326, AK164236
    Consensus CDS
    CCDS50444.1
    UniProtKB/TrEMBL
    E9Q605, Q3TPN9, Q8CBT3
    Related
    ENSMUSP00000113809.1, OTTMUSP00000038221, ENSMUST00000119591.1, OTTMUST00000073745
    Conserved Domains (2) summary
    smart00220
    Location:15298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
  2. NM_007700.2NP_031726.2  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124693, AK035326, AK150039, AK164236
    Consensus CDS
    CCDS29843.1
    UniProtKB/TrEMBL
    E9QNL4, Q3TPN9, Q3UDK0, Q8CBT3
    Related
    ENSMUSP00000026217.4, OTTMUSP00000038220, ENSMUST00000026217.10, OTTMUST00000073744
    Conserved Domains (3) summary
    smart00220
    Location:15298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
    pfam12179
    Location:709743
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    44073334..44107509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247129.2XP_011245431.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:15298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

RNA

  1. XR_001782557.1 RNA Sequence

  2. XR_001782558.1 RNA Sequence

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