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Chuk conserved helix-loop-helix ubiquitous kinase [ Mus musculus (house mouse) ]

Gene ID: 12675, updated on 19-Sep-2021

Summary

Official Symbol
Chukprovided by MGI
Official Full Name
conserved helix-loop-helix ubiquitous kinaseprovided by MGI
Primary source
MGI:MGI:99484
See related
Ensembl:ENSMUSG00000025199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IKK; IKK-; IKK1; IKK[; Ikka; Chuk1; Fbx24; IKBKA; Fbxo24; NFKBIKA; AI256658; IKK alpha
Expression
Ubiquitous expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 11.6) and 28 other tissues See more
Orthologs
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Genomic context

See Chuk in Genome Data Viewer
Location:
19 C3; 19 36.71 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44061773..44095940, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44073334..44107505, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44147824..44181967, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23 Neighboring gene ER lipid raft associated 1 Neighboring gene uracil DNA glycosylase pseudogene Neighboring gene CWF19-like 1, cell cycle control (S. pombe) Neighboring gene predicted gene, 24336 Neighboring gene predicted gene, 52383

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25325

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to IkappaB kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to IkappaB kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within I-kappaB phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lactation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cholecystokinin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit alpha
Names
I kappa B kinase 1
I-kappa-B kinase alpha
IkappaB kinase alpha
nuclear factor NF-kappa-B inhibitor kinase alpha
NP_001155882.1
NP_031726.2
XP_030106592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162410.1NP_001155882.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC124693, AK035326, AK164236
    Consensus CDS
    CCDS50444.1
    UniProtKB/TrEMBL
    E9Q605, Q3TPN9, Q8CBT3
    Related
    ENSMUSP00000113809.2, ENSMUST00000119591.2
    Conserved Domains (2) summary
    smart00220
    Location:15298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
  2. NM_007700.2NP_031726.2  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124693, AK035326, AK150039, AK164236
    Consensus CDS
    CCDS29843.1
    UniProtKB/TrEMBL
    E9QNL4, Q3TPN9, Q3UDK0, Q8CBT3
    Related
    ENSMUSP00000026217.5, ENSMUST00000026217.11
    Conserved Domains (3) summary
    smart00220
    Location:15298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
    pfam12179
    Location:709743
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44061773..44095940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250732.2XP_030106592.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

    Conserved Domains (3) summary
    cd14039
    Location:21309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
    cd17046
    Location:311387
    Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
    pfam18397
    Location:386659
    IKBKB_SDD; IQBAL scaffold dimerization domain

RNA

  1. XR_003952742.2 RNA Sequence

  2. XR_003952741.2 RNA Sequence

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