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    CIB1 calcium and integrin binding 1 [ Homo sapiens (human) ]

    Gene ID: 10519, updated on 17-Jun-2024

    Summary

    Official Symbol
    CIB1provided by HGNC
    Official Full Name
    calcium and integrin binding 1provided by HGNC
    Primary source
    HGNC:HGNC:16920
    See related
    Ensembl:ENSG00000185043 MIM:602293; AllianceGenome:HGNC:16920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIB; EV3; CIBP; KIP1; PRKDCIP; SIP2-28
    Summary
    This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
    Expression
    Ubiquitous expression in colon (RPKM 49.7), adrenal (RPKM 37.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CIB1 in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90229975..90265759, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87985982..88021749, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90773207..90808991, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 346, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90717667-90718167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90721295-90722200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90727462-90728195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10067 Neighboring gene semaphorin 4B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90744110-90745081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10068 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:90754487-90755686 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90755750-90755924 Neighboring gene ribosomal protein S12 pseudogene 26 Neighboring gene Sharpr-MPRA regulatory region 13535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90764595-90765433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6818 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene tubulin tyrosine ligase like 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90807916-90808887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90808888-90809858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90818447-90819000 Neighboring gene neugrin, neurite outgrowth associated Neighboring gene PERP pseudogene 2 Neighboring gene NIFK pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication, specifically viral entry, requires CIB1 and CIB2 expression as shRNA knockdown of each impairs replication in Jurkat and primary CD4+ T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium-dependent protein kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-membrane adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to nerve growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endomitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of calcineurin-NFAT signaling cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of male germ cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thrombopoietin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle HDA PubMed 

    General protein information

    Preferred Names
    calcium and integrin-binding protein 1
    Names
    DNA-PK interaction protein
    DNA-PKcs-interacting protein
    DNA-dependent protein kinase interacting protein
    SNK-interacting protein 2-28
    calcium and integrin binding 1 (calmyrin)
    testicular secretory protein Li 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277764.2NP_001264693.1  calcium and integrin-binding protein 1 isoform a

      See identical proteins and their annotated locations for NP_001264693.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longer isoform (a, also known as CIB1a).
      Source sequence(s)
      AC091167, BG231771, CD622547, JQ246073
      Consensus CDS
      CCDS73781.1
      UniProtKB/Swiss-Prot
      Q99828
      Related
      ENSP00000479860.1, ENST00000612800.1
      Conserved Domains (3) summary
      cd00051
      Location:151218
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:149217
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:122172
      EF-hand_8; EF-hand domain pair
    2. NM_006384.4NP_006375.2  calcium and integrin-binding protein 1 isoform b

      See identical proteins and their annotated locations for NP_006375.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) uses an alternate splice site in the coding region, compared to variant a. The encoded isoform (b, also known as CIB1) is shorter, compared to isoform a.
      Source sequence(s)
      AA769426, AC091167, CD622547, U82226
      Consensus CDS
      CCDS10360.1
      UniProtKB/Swiss-Prot
      B5BU40, H6WJF3, O00693, O00735, Q6IB49, Q96J54, Q99828, Q99971
      UniProtKB/TrEMBL
      A0A140VK09
      Related
      ENSP00000333873.6, ENST00000328649.11
      Conserved Domains (1) summary
      COG5126
      Location:67182
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RNA

    1. NR_102427.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) uses an alternate 5' exon and an alternate splice site in an internal exon, compared to variant a. This variant is represented as non-coding because it lacks the translation start site used in variant a and does not include a supported in-frame ORF.
      Source sequence(s)
      BG231771, BI520476, HY070030
    2. NR_102428.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BG231771, BG759961

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      90229975..90265759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006720375.3XP_006720438.1  calcium and integrin-binding protein 1 isoform X1

      Conserved Domains (3) summary
      cd00051
      Location:111178
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:109177
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:82132
      EF-hand_8; EF-hand domain pair

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      87985982..88021749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377210.1XP_054233185.1  calcium and integrin-binding protein 1 isoform X1