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    Aamp angio-associated, migratory cell protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301512, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aampprovided by RGD
    Official Full Name
    angio-associated, migratory cell proteinprovided by RGD
    Primary source
    RGD:1306281
    See related
    Ensembl:ENSRNOG00000014399 AllianceGenome:RGD:1306281
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heparin binding activity. Predicted to be involved in smooth muscle cell migration. Predicted to be located in cell surface; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human AAMP (angio associated migratory cell protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 263.4), Testes (RPKM 229.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83312519..83318325, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (75863382..75869188, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81560836..81566642, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690558 Neighboring gene actin related protein 2/3 complex, subunit 2 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene PNKD metallo-beta-lactamase domain containing Neighboring gene ciliogenesis associated TTC17 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis. Vogt F, et al. J Am Coll Cardiol, 2008 Jul 22. PMID 18634987
    2. Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells. Beckner ME, et al. Microvasc Res, 1999 May. PMID 10329261
    3. Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. Beckner ME, et al. Cancer Res, 1995 May 15. PMID 7743515
    4. AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling. Hu J, et al. Ann Biomed Eng, 2016 May. PMID 26350504
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
      Title: AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    angio-associated migratory cell protein
    Names
    angio-associated migratory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106920.1 → NP_001100390.1  angio-associated migratory cell protein

      See identical proteins and their annotated locations for NP_001100390.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474004
      UniProtKB/TrEMBL
      A6JVT3, B0K024
      Conserved Domains (3) summary
      smart00320
      Location:390 → 428
      WD40; WD40 repeats
      cd00200
      Location:87 → 387
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:138 → 176
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83312519..83318325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245167.5 → XP_006245229.1  angio-associated migratory cell protein isoform X1

      UniProtKB/TrEMBL
      B0K024
      Conserved Domains (3) summary
      smart00320
      Location:391 → 429
      WD40; WD40 repeats
      cd00200
      Location:88 → 388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:139 → 177
      7WD40; WD40 repeat [structural motif]

    2. XM_006245169.4 → XP_006245231.1  angio-associated migratory cell protein isoform X3

      UniProtKB/TrEMBL
      B0K024
      Conserved Domains (4) summary
      smart00320
      Location:384 → 422
      WD40; WD40 repeats
      COG2319
      Location:84 → 425
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:81 → 381
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:132 → 170
      7WD40; WD40 repeat [structural motif]

    3. XM_006245168.4 → XP_006245230.1  angio-associated migratory cell protein isoform X2

      UniProtKB/TrEMBL
      B0K024, G3V7V2
      Related
      ENSRNOP00000019497.6
      Conserved Domains (4) summary
      smart00320
      Location:385 → 423
      WD40; WD40 repeats
      COG2319
      Location:85 → 426
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:82 → 382
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:133 → 171
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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