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AAMP angio associated migratory cell protein [ Homo sapiens (human) ]

Gene ID: 14, updated on 5-Aug-2018

Summary

Official Symbol
AAMPprovided by HGNC
Official Full Name
angio associated migratory cell proteinprovided by HGNC
Primary source
HGNC:HGNC:18
See related
Ensembl:ENSG00000127837 MIM:603488; Vega:OTTHUMG00000155202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in ovary (RPKM 40.5), thyroid (RPKM 38.1) and 25 other tissues See more
Orthologs

Genomic context

See AAMP in Genome Data Viewer
Location:
2q35
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (218264127..218270209, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219128852..219134893, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene transfer RNA-Tyr (ATA) 1-1 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene PNKD, MBL domain containing Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene microRNA 6513 Neighboring gene uncharacterized LOC105373881 Neighboring gene uncharacterized LOC105373880

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smooth muscle cell migration IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
angio-associated migratory cell protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033036.1 RefSeqGene

    Range
    4962..11042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001087.4NP_001078.2  angio-associated migratory cell protein isoform 2

    See identical proteins and their annotated locations for NP_001078.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    BC008809, BC014122, DA277259, DA465288, HY374777
    Consensus CDS
    CCDS33378.1
    UniProtKB/Swiss-Prot
    Q13685
    UniProtKB/TrEMBL
    A0A024R410
    Related
    ENSP00000248450.4, OTTHUMP00000207408, ENST00000248450.8, OTTHUMT00000338756
    Conserved Domains (3) summary
    smart00320
    Location:389427
    WD40; WD40 repeats
    cd00200
    Location:86386
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:94132
    7WD40; WD40 repeat [structural motif]
  2. NM_001302545.1NP_001289474.1  angio-associated migratory cell protein isoform 1

    See identical proteins and their annotated locations for NP_001289474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC021016, AK225078, DA277259
    Consensus CDS
    CCDS77530.1
    UniProtKB/TrEMBL
    C9JEH3
    Related
    ENSP00000403343.1, OTTHUMP00000207409, ENST00000444053.5, OTTHUMT00000338757
    Conserved Domains (3) summary
    smart00320
    Location:390428
    WD40; WD40 repeats
    cd00200
    Location:87387
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:95133
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    218264127..218270209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452712.1XP_024308480.1  angio-associated migratory cell protein isoform X1

    Conserved Domains (2) summary
    cd00200
    Location:86361
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:94132
    7WD40; WD40 repeat [structural motif]
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