U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    HSF1 heat shock transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 3297, updated on 17-Jun-2024

    Summary

    Official Symbol
    HSF1provided by HGNC
    Official Full Name
    heat shock transcription factor 1provided by HGNC
    Primary source
    HGNC:HGNC:5224
    See related
    Ensembl:ENSG00000185122 MIM:140580; AllianceGenome:HGNC:5224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSTF1
    Summary
    The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in testis (RPKM 49.6), heart (RPKM 24.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HSF1 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144291604..144314720)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145460056..145483355)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145515286..145538383)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145321725-145322492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145322493-145323258 Neighboring gene microRNA 7112 Neighboring gene BOP1 ribosomal biogenesis factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145494989-145495632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145495633-145496276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145498855-145499497 Neighboring gene scleraxis bHLH transcription factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19671 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145515765-145516421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145536471-145537002 Neighboring gene uncharacterized LOC124902050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145543593-145544435 Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene microRNA 6848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145555531-145556238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145556239-145556947 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145556948-145557655 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145558559-145559174 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145559298-145559484 Neighboring gene scratch family transcriptional repressor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef physically interacts and co-localizes with HSF1 in cells. HSF1 is induced in HIV-1-infected cells and enhances HIV-1 LTR-driven gene expression PubMed
    Vpr vpr Activation of HSP27 is mediated through heat shock factor 1 and is counteracted by HIV-1 Vpr PubMed
    vpr HIV-1 Vpr upregulates heat shock transcription factor 1 (HSF1) in PHA-stimulated PBMC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables STAT family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables general transcription initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heat shock protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables promoter-specific chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific single stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation elongation factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to L-glutamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to copper ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to diamide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitroglycerin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to potassium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to sodium arsenite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to unfolded protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inclusion body assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inclusion body assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress granule assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypobaric hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to psychosocial stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    part_of heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein folding chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock factor protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005526.4NP_005517.1  heat shock factor protein 1

      See identical proteins and their annotated locations for NP_005517.1

      Status: REVIEWED

      Source sequence(s)
      BU617486, M64673
      Consensus CDS
      CCDS6419.1
      UniProtKB/Swiss-Prot
      A8K4L0, A8MW26, Q00613, Q53XT4
      UniProtKB/TrEMBL
      Q53HT3
      Related
      ENSP00000431512.1, ENST00000528838.6
      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:252529
      Vert_HS_TF; Vertebrate heat shock transcription factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144291604..144314720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272315.4XP_005272372.1  heat shock factor protein 1 isoform X1

      UniProtKB/TrEMBL
      Q53HT3
      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:252557
      Vert_HS_TF; Vertebrate heat shock transcription factor
    2. XM_005272316.4XP_005272373.1  heat shock factor protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PMQ6
      Related
      ENSP00000383590.5, ENST00000400780.8
      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:252489
      Vert_HS_TF; Vertebrate heat shock transcription factor
    3. XM_017013377.3XP_016868866.1  heat shock factor protein 1 isoform X3

      UniProtKB/TrEMBL
      E9PMQ6
    4. XM_047421742.1XP_047277698.1  heat shock factor protein 1 isoform X5

    5. XM_005272317.3XP_005272374.1  heat shock factor protein 1 isoform X5

      Conserved Domains (3) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:252288
      Vert_HS_TF; Vertebrate heat shock transcription factor
      cl23789
      Location:72182
      PLN02481; Omega-hydroxypalmitate O-feruloyl transferase
    6. XM_047421743.1XP_047277699.1  heat shock factor protein 1 isoform X6

    7. XM_047421740.1XP_047277696.1  heat shock factor protein 1 isoform X4

      UniProtKB/TrEMBL
      Q53HT3
    8. XM_047421741.1XP_047277697.1  heat shock factor protein 1 isoform X4

      UniProtKB/TrEMBL
      Q53HT3
    9. XM_011517006.3XP_011515308.1  heat shock factor protein 1 isoform X7

      Conserved Domains (1) summary
      pfam06546
      Location:2272
      Vert_HS_TF; Vertebrate heat shock transcription factor

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654716.1 Reference GRCh38.p14 PATCHES

      Range
      22207..45323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332193.1XP_054188168.1  heat shock factor protein 1 isoform X1

      UniProtKB/TrEMBL
      Q53HT3
    2. XM_054332194.1XP_054188169.1  heat shock factor protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PMQ6
    3. XM_054332195.1XP_054188170.1  heat shock factor protein 1 isoform X3

      UniProtKB/TrEMBL
      E9PMQ6
    4. XM_054332198.1XP_054188173.1  heat shock factor protein 1 isoform X5

    5. XM_054332199.1XP_054188174.1  heat shock factor protein 1 isoform X5

    6. XM_054332200.1XP_054188175.1  heat shock factor protein 1 isoform X6

    7. XM_054332196.1XP_054188171.1  heat shock factor protein 1 isoform X4

      UniProtKB/TrEMBL
      Q53HT3
    8. XM_054332197.1XP_054188172.1  heat shock factor protein 1 isoform X4

      UniProtKB/TrEMBL
      Q53HT3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145460056..145483355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360397.1XP_054216372.1  heat shock factor protein 1 isoform X1

      UniProtKB/TrEMBL
      Q53HT3
    2. XM_054360398.1XP_054216373.1  heat shock factor protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PMQ6
    3. XM_054360399.1XP_054216374.1  heat shock factor protein 1 isoform X3

      UniProtKB/TrEMBL
      E9PMQ6
    4. XM_054360402.1XP_054216377.1  heat shock factor protein 1 isoform X5

    5. XM_054360403.1XP_054216378.1  heat shock factor protein 1 isoform X5

    6. XM_054360404.1XP_054216379.1  heat shock factor protein 1 isoform X6

    7. XM_054360400.1XP_054216375.1  heat shock factor protein 1 isoform X4

      UniProtKB/TrEMBL
      Q53HT3
    8. XM_054360401.1XP_054216376.1  heat shock factor protein 1 isoform X4

      UniProtKB/TrEMBL
      Q53HT3