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Hsf1 heat shock factor 1 [ Mus musculus (house mouse) ]

Gene ID: 15499, updated on 6-Sep-2021

Summary

Official Symbol
Hsf1provided by MGI
Official Full Name
heat shock factor 1provided by MGI
Primary source
MGI:MGI:96238
See related
Ensembl:ENSMUSG00000022556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HSTF; HSTF 1; AA960185; Hsf1beta; Hsf1alpha
Expression
Ubiquitous expression in ovary adult (RPKM 47.3), thymus adult (RPKM 42.2) and 28 other tissues See more
Orthologs
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Genomic context

See Hsf1 in Genome Data Viewer
Location:
15 D3; 15 35.95 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76361562..76385355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76477362..76501155)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (76307875..76331402)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene block of proliferation 1 Neighboring gene scleraxis Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene scratch family zinc finger 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific single stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables translation elongation factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to copper ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to diamide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to sodium arsenite ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic process involved in female pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA polyadenylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to heat stress ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of spindle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to testosterone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chaperone complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock factor protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331152.1NP_001318081.1  heat shock factor protein 1 isoform gammaalpha

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (gammaalpha).
    Source sequence(s)
    AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418
    UniProtKB/TrEMBL
    A0A075F6C2
  2. NM_001331153.1NP_001318082.1  heat shock factor protein 1 isoform gammabeta

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform gammabeta which is shorter compared to isoform gammaalpha.
    Source sequence(s)
    AC157566, AK075651, BQ445304, BU925102, CB245398
    Consensus CDS
    CCDS88785.1
    UniProtKB/TrEMBL
    A0A075F5C6
    Related
    ENSMUSP00000154638.2, ENSMUST00000228371.2
  3. NM_001331154.1NP_001318083.1  heat shock factor protein 1 isoform alpha

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform alpha which is shorter compared to isoform gammaalpha.
    Source sequence(s)
    AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418
    Consensus CDS
    CCDS88787.1
    UniProtKB/Swiss-Prot
    P38532
    UniProtKB/TrEMBL
    A0A075F891
    Related
    ENSMUSP00000154602.2, ENSMUST00000227478.2
  4. NM_001331214.1NP_001318143.1  heat shock factor protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 5, which has a shorter and distinct C-terminus, compared to isoform gammaalpha.
    Source sequence(s)
    AC157566, AK075651, BQ445304, BU925102, CB245398
    Consensus CDS
    CCDS88786.1
    UniProtKB/TrEMBL
    Q52L52
    Related
    ENSMUSP00000154328.2, ENSMUST00000226872.2
  5. NM_008296.3NP_032322.1  heat shock factor protein 1 isoform beta

    See identical proteins and their annotated locations for NP_032322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform beta which is shorter compared to isoform gammaalpha.
    Source sequence(s)
    AC157566, AK075651, BQ445304, BU925102, CB245398
    Consensus CDS
    CCDS27572.1
    UniProtKB/Swiss-Prot
    P38532
    UniProtKB/TrEMBL
    A0A075F882
    Related
    ENSMUSP00000072617.6, ENSMUST00000072838.6
    Conserved Domains (2) summary
    smart00415
    Location:14118
    HSF; heat shock factor
    pfam06546
    Location:258503
    Vert_HS_TF; Vertebrate heat shock transcription factor

RNA

  1. NR_138588.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate internal exons and retains an intron in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC157566, AK075651, AK089144, BG694608, BQ445304, BU925102, CB245398
    Related
    ENSMUST00000228868.2
  2. NR_138589.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks multiple alternate internal exons and uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant gammaalpha, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC157566, AK075651, AK082507, BQ445304, BU925102, CB245398, CK622418

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76361562..76385355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159166.1XP_036015059.1  heat shock factor protein 1 isoform X2

    Conserved Domains (1) summary
    pfam06546
    Location:47314
    Vert_HS_TF; Vertebrate heat shock transcription factor
  2. XM_036159167.1XP_036015060.1  heat shock factor protein 1 isoform X3

    Conserved Domains (1) summary
    pfam06546
    Location:47292
    Vert_HS_TF; Vertebrate heat shock transcription factor
  3. XM_036159165.1XP_036015058.1  heat shock factor protein 1 isoform X2

    Conserved Domains (1) summary
    pfam06546
    Location:47314
    Vert_HS_TF; Vertebrate heat shock transcription factor
  4. XM_030248342.2XP_030104202.1  heat shock factor protein 1 isoform X3

    Conserved Domains (1) summary
    pfam06546
    Location:47292
    Vert_HS_TF; Vertebrate heat shock transcription factor
  5. XM_006520476.5XP_006520539.1  heat shock factor protein 1 isoform X3

    Conserved Domains (1) summary
    pfam06546
    Location:47292
    Vert_HS_TF; Vertebrate heat shock transcription factor
  6. XM_006520474.5XP_006520537.1  heat shock factor protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006520537.1

    Conserved Domains (1) summary
    pfam06546
    Location:47342
    Vert_HS_TF; Vertebrate heat shock transcription factor
  7. XM_006520475.5XP_006520538.1  heat shock factor protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006520538.1

    Conserved Domains (1) summary
    pfam06546
    Location:47342
    Vert_HS_TF; Vertebrate heat shock transcription factor
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