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HSF1 heat shock transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 3297, updated on 7-Oct-2018

Summary

Official Symbol
HSF1provided by HGNC
Official Full Name
heat shock transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:5224
See related
Ensembl:ENSG00000185122 MIM:140580; Vega:OTTHUMG00000174604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSTF1
Summary
The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in testis (RPKM 49.6), heart (RPKM 24.2) and 25 other tissues See more
Orthologs

Genomic context

See HSF1 in Genome Data Viewer
Location:
8q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (144291569..144314726)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145515270..145538385)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 7112 Neighboring gene block of proliferation 1 Neighboring gene scleraxis bHLH transcription factor Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene microRNA 6848 Neighboring gene scratch family transcriptional repressor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef physically interacts and co-localizes with HSF1 in cells. HSF1 is induced in HIV-1-infected cells and enhances HIV-1 LTR-driven gene expression PubMed
Vpr vpr Activation of HSP27 is mediated through heat shock factor 1 and is counteracted by HIV-1 Vpr PubMed
vpr HIV-1 Vpr upregulates heat shock transcription factor 1 (HSF1) in PHA-stimulated PBMC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Attenuation phase, organism-specific biosystem (from REACTOME)
    Attenuation phase, organism-specific biosystemAttenuation of the heat shock transcriptional response occurs during continuous exposure to intermediate heat shock conditions or upon recovery from stress (Abravaya et al. 1991). The attenuation pha...
  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • HSF1 activation, organism-specific biosystem (from REACTOME)
    HSF1 activation, organism-specific biosystemHeat shock factor 1 (HSF1) is a transcription factor that activates gene expression in response to a variety of stresses, including heat shock, oxidative stress, as well as inflammation and infection...
  • HSF1-dependent transactivation, organism-specific biosystem (from REACTOME)
    HSF1-dependent transactivation, organism-specific biosystemAcquisition of DNA binding activity by HSF1 is necessary but insufficient for transcriptional activation (Cotto JJ et al. 1996; Trinklein ND et al. 2004). In addition to having a sequence-specific DN...
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
STAT family protein binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
heat shock protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific single stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to L-glutamine IEA
Inferred from Electronic Annotation
more info
 
cellular response to angiotensin IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to copper ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to diamide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitroglycerin IEA
Inferred from Electronic Annotation
more info
 
cellular response to potassium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to sodium arsenite IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to unfolded protein IDA
Inferred from Direct Assay
more info
PubMed 
defense response IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
embryonic process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
female meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inclusion body assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inclusion body assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of microtubule binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to heat stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to heat stress IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to hypobaric hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to psychosocial stress IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
euchromatin IEA
Inferred from Electronic Annotation
more info
 
heterochromatin IEA
Inferred from Electronic Annotation
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
nuclear stress granule IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
pronucleus IEA
Inferred from Electronic Annotation
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock factor protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005526.3NP_005517.1  heat shock factor protein 1

    See identical proteins and their annotated locations for NP_005517.1

    Status: REVIEWED

    Source sequence(s)
    AC233992, BU617486, M64673
    Consensus CDS
    CCDS6419.1
    UniProtKB/Swiss-Prot
    Q00613
    Related
    ENSP00000431512.1, OTTHUMP00000252235, ENST00000528838.5, OTTHUMT00000426985
    Conserved Domains (2) summary
    smart00415
    Location:14118
    HSF; heat shock factor
    pfam06546
    Location:252529
    Vert_HS_TF; Vertebrate heat shock transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    144291569..144314726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272315.3XP_005272372.1  heat shock factor protein 1 isoform X1

    Conserved Domains (2) summary
    smart00415
    Location:14118
    HSF; heat shock factor
    pfam06546
    Location:252557
    Vert_HS_TF; Vertebrate heat shock transcription factor
  2. XM_005272316.3XP_005272373.1  heat shock factor protein 1 isoform X2

    Related
    ENSP00000383590.5, OTTHUMP00000252237, ENST00000400780.8
    Conserved Domains (2) summary
    smart00415
    Location:14118
    HSF; heat shock factor
    pfam06546
    Location:252489
    Vert_HS_TF; Vertebrate heat shock transcription factor
  3. XM_017013377.2XP_016868866.1  heat shock factor protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q00613
  4. XM_005272317.2XP_005272374.1  heat shock factor protein 1 isoform X6

    Conserved Domains (3) summary
    smart00415
    Location:14118
    HSF; heat shock factor
    pfam06546
    Location:252288
    Vert_HS_TF; Vertebrate heat shock transcription factor
    cl23789
    Location:72182
    PLN02481; Omega-hydroxypalmitate O-feruloyl transferase
  5. XM_024447144.1XP_024302912.1  heat shock factor protein 1 isoform X5

    Conserved Domains (1) summary
    pfam06546
    Location:41318
    Vert_HS_TF; Vertebrate heat shock transcription factor
  6. XM_011517004.2XP_011515306.1  heat shock factor protein 1 isoform X4

    Conserved Domains (1) summary
    pfam06546
    Location:41346
    Vert_HS_TF; Vertebrate heat shock transcription factor
  7. XM_011517006.2XP_011515308.1  heat shock factor protein 1 isoform X7

    Conserved Domains (1) summary
    pfam06546
    Location:2272
    Vert_HS_TF; Vertebrate heat shock transcription factor

RNA

  1. XR_001745527.2 RNA Sequence

  2. XR_246618.4 RNA Sequence

  3. XR_001745526.2 RNA Sequence

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_018654716.1 Reference GRCh38.p12 PATCHES

    Range
    22172..45329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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