HSF1 heat shock transcription factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSF1provided by HGNC
Official Full Name: heat shock transcription factor 1provided by HGNC
Primary source: HGNC:HGNC:5224
See related: Ensembl:ENSG00000185122 MIM:140580; AllianceGenome:HGNC:5224
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSTF1
Summary: The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]
Expression: Ubiquitous expression in testis (RPKM 49.6), heart (RPKM 24.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (144291604..144314720)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (145460056..145483355)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (145515286..145538383)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication.
Title: Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication.
Bag-1-mediated HSF1 phosphorylation regulates expression of heat shock proteins in breast cancer cells.
Title: Bag-1-mediated HSF1 phosphorylation regulates expression of heat shock proteins in breast cancer cells.
Protein Misfolding Releases Human HSF1 from HSP70 Latency Control.
Title: Protein Misfolding Releases Human HSF1 from HSP70 Latency Control.
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment.
Title: Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment.
Intermolecular Interactions between Cysteine and Aromatic Amino Acids with a Phenyl Moiety in the DNA-Binding Domain of Heat Shock Factor 1 Regulate Thermal Stress-Induced Trimerization.
Title: Intermolecular Interactions between Cysteine and Aromatic Amino Acids with a Phenyl Moiety in the DNA-Binding Domain of Heat Shock Factor 1 Regulate Thermal Stress-Induced Trimerization.
Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Title: Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2.
Title: Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2.
Cellular HSF1 expression is induced during HIV-1 infection by activation of its promoter mediated through the cooperative interaction of HSF1 and viral Nef protein.
Title: Cellular HSF1 expression is induced during HIV-1 infection by activation of its promoter mediated through the cooperative interaction of HSF1 and viral Nef protein.
ER Stress-Activated HSF1 Governs Cancer Cell Resistance to USP7 Inhibitor-Based Chemotherapy through the PERK Pathway.
Title: ER Stress-Activated HSF1 Governs Cancer Cell Resistance to USP7 Inhibitor-Based Chemotherapy through the PERK Pathway.
Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation.
Title: Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation.

Submit: New GeneRIF Correction See all GeneRIFs (324)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef physically interacts and co-localizes with HSF1 in cells. HSF1 is induced in HIV-1-infected cells and enhances HIV-1 LTR-driven gene expression	PubMed
Vpr	vpr	Activation of HSP27 is mediated through heat shock factor 1 and is counteracted by HIV-1 Vpr	PubMed
	vpr	HIV-1 Vpr upregulates heat shock transcription factor 1 (HSF1) in PHA-stimulated PBMC	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-M64673 (e-PCR)
- UniSTS:47479

HSC2HB072 (e-PCR)
- UniSTS:10638

D15S621E (e-PCR)
- UniSTS:149963

RH79683 (e-PCR)
- UniSTS:85756

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables general transcription initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables heat shock protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables translation elongation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to copper ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to diamide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to sodium arsenite	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to unfolded protein	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic process involved in female pregnancy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to heat	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in pronucleus	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock factor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005526.4 → NP_005517.1 heat shock factor protein 1

See identical proteins and their annotated locations for NP_005517.1

Status: REVIEWED

Source sequence(s)

BU617486, M64673

Consensus CDS

CCDS6419.1

UniProtKB/Swiss-Prot

A8K4L0, A8MW26, Q00613, Q53XT4

UniProtKB/TrEMBL

Q53HT3

Related

ENSP00000431512.1, ENST00000528838.6

Conserved Domains (2) summary

smart00415
Location:14 → 118

HSF; heat shock factor

pfam06546
Location:252 → 529

Vert_HS_TF; Vertebrate heat shock transcription factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

144291604..144314720

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005272315.4 → XP_005272372.1 heat shock factor protein 1 isoform X1

UniProtKB/TrEMBL

Q53HT3

Related

ENSP00000532656.1, ENST00000862597.1

Conserved Domains (2) summary

smart00415
Location:14 → 118

HSF; heat shock factor

pfam06546
Location:252 → 557

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_005272316.4 → XP_005272373.1 heat shock factor protein 1 isoform X2

UniProtKB/TrEMBL

E9PMQ6

Related

ENSP00000383590.5, ENST00000400780.8

Conserved Domains (2) summary

smart00415
Location:14 → 118

HSF; heat shock factor

pfam06546
Location:252 → 489

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_017013377.3 → XP_016868866.1 heat shock factor protein 1 isoform X3

UniProtKB/TrEMBL

E9PMQ6
XM_047421742.1 → XP_047277698.1 heat shock factor protein 1 isoform X5
XM_005272317.3 → XP_005272374.1 heat shock factor protein 1 isoform X5

Conserved Domains (3) summary

smart00415
Location:14 → 118

HSF; heat shock factor

pfam06546
Location:252 → 288

Vert_HS_TF; Vertebrate heat shock transcription factor

cl23789
Location:72 → 182

PLN02481; Omega-hydroxypalmitate O-feruloyl transferase
XM_047421743.1 → XP_047277699.1 heat shock factor protein 1 isoform X6
XM_047421740.1 → XP_047277696.1 heat shock factor protein 1 isoform X4

UniProtKB/TrEMBL

Q53HT3
XM_047421741.1 → XP_047277697.1 heat shock factor protein 1 isoform X4

UniProtKB/TrEMBL

Q53HT3
XM_011517006.3 → XP_011515308.1 heat shock factor protein 1 isoform X7

Conserved Domains (1) summary

pfam06546
Location:2 → 272

Vert_HS_TF; Vertebrate heat shock transcription factor

Reference GRCh38.p14 PATCHES

Genomic

NW_018654716.1 Reference GRCh38.p14 PATCHES

Range

22207..45323

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054332193.1 → XP_054188168.1 heat shock factor protein 1 isoform X1

UniProtKB/TrEMBL

Q53HT3
XM_054332194.1 → XP_054188169.1 heat shock factor protein 1 isoform X2

UniProtKB/TrEMBL

E9PMQ6
XM_054332195.1 → XP_054188170.1 heat shock factor protein 1 isoform X3

UniProtKB/TrEMBL

E9PMQ6
XM_054332198.1 → XP_054188173.1 heat shock factor protein 1 isoform X5
XM_054332199.1 → XP_054188174.1 heat shock factor protein 1 isoform X5
XM_054332200.1 → XP_054188175.1 heat shock factor protein 1 isoform X6
XM_054332196.1 → XP_054188171.1 heat shock factor protein 1 isoform X4

UniProtKB/TrEMBL

Q53HT3
XM_054332197.1 → XP_054188172.1 heat shock factor protein 1 isoform X4

UniProtKB/TrEMBL

Q53HT3

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

145460056..145483355

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054360397.1 → XP_054216372.1 heat shock factor protein 1 isoform X1

UniProtKB/TrEMBL

Q53HT3
XM_054360398.1 → XP_054216373.1 heat shock factor protein 1 isoform X2

UniProtKB/TrEMBL

E9PMQ6
XM_054360399.1 → XP_054216374.1 heat shock factor protein 1 isoform X3

UniProtKB/TrEMBL

E9PMQ6
XM_054360402.1 → XP_054216377.1 heat shock factor protein 1 isoform X5
XM_054360403.1 → XP_054216378.1 heat shock factor protein 1 isoform X5
XM_054360404.1 → XP_054216379.1 heat shock factor protein 1 isoform X6
XM_054360400.1 → XP_054216375.1 heat shock factor protein 1 isoform X4

UniProtKB/TrEMBL

Q53HT3
XM_054360401.1 → XP_054216376.1 heat shock factor protein 1 isoform X4

UniProtKB/TrEMBL

Q53HT3