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    ZNF273 zinc finger protein 273 [ Homo sapiens (human) ]

    Gene ID: 10793, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF273provided by HGNC
    Official Full Name
    zinc finger protein 273provided by HGNC
    Primary source
    HGNC:HGNC:13067
    See related
    Ensembl:ENSG00000198039 MIM:604756; AllianceGenome:HGNC:13067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZF9
    Summary
    This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 16.5), bone marrow (RPKM 2.0) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF273 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64877603..64937316)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (66083757..66137245)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64337981..64391359)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64315844-64316400 Neighboring gene selenophosphate synthetase 1 pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64348006-64348724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64348725-64349442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64350161-64350877 Neighboring gene uncharacterized LOC441239 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64362646-64363518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64363519-64364391 Neighboring gene vomeronasal 1 receptor 42 pseudogene Neighboring gene metadherin pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64428091-64428834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64428835-64429578 Neighboring gene ERV3-1-ZNF117 readthrough Neighboring gene MPRA-validated peak6534 silencer Neighboring gene vomeronasal 1 receptor 43 pseudogene Neighboring gene zinc finger protein 117

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC12518

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 273
    Names
    zinc finger protein 9
    zinc finger protein HZF9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385643.1NP_001372572.1  zinc finger protein 273 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
      Conserved Domains (3) summary
      COG5048
      Location:126472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    2. NM_001385644.1NP_001372573.1  zinc finger protein 273 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
      Conserved Domains (3) summary
      COG5048
      Location:126472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    3. NM_001385645.1NP_001372574.1  zinc finger protein 273 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
      Conserved Domains (3) summary
      COG5048
      Location:126472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    4. NM_001385646.1NP_001372575.1  zinc finger protein 273 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092161
      Conserved Domains (2) summary
      COG5048
      Location:94440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:251271
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001385647.1NP_001372576.1  zinc finger protein 273 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC092161
      Conserved Domains (1) summary
      smart00349
      Location:3797
      KRAB; krueppel associated box
    6. NM_001385649.1NP_001372578.1  zinc finger protein 273 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
      Conserved Domains (3) summary
      COG5048
      Location:126472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    7. NM_001385650.1NP_001372579.1  zinc finger protein 273 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC092161
      Conserved Domains (1) summary
      smart00349
      Location:3797
      KRAB; krueppel associated box
    8. NM_001385652.1NP_001372581.1  zinc finger protein 273 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092161
      Conserved Domains (3) summary
      COG5048
      Location:126472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    9. NM_001388021.1NP_001374950.1  zinc finger protein 273 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
      Conserved Domains (3) summary
      COG5048
      Location:126472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    10. NM_021148.3NP_066971.2  zinc finger protein 273 isoform 1

      See identical proteins and their annotated locations for NP_066971.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC092161
      Consensus CDS
      CCDS5528.2
      UniProtKB/Swiss-Prot
      B3KQZ5, Q14593, Q6P3V4
      Related
      ENSP00000418719.1, ENST00000476120.2
      Conserved Domains (5) summary
      smart00349
      Location:3797
      KRAB; krueppel associated box
      COG5048
      Location:191537
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:348368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3776
      KRAB; KRAB box
      pfam13465
      Location:501525
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_169738.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
    2. NR_169741.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
    3. NR_169742.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
    4. NR_169743.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
    5. NR_169744.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
    6. NR_169745.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
    7. NR_169746.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073349, AC092161
    8. NR_169747.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092161
    9. NR_169748.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092161
    10. NR_170871.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092161
      Related
      ENST00000489672.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      64877603..64937316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419800.1XP_047275756.1  zinc finger protein 273 isoform X2

    2. XM_047419813.1XP_047275769.1  zinc finger protein 273 isoform X2

    3. XM_047419803.1XP_047275759.1  zinc finger protein 273 isoform X2

    4. XM_047419809.1XP_047275765.1  zinc finger protein 273 isoform X2

    5. XM_047419812.1XP_047275768.1  zinc finger protein 273 isoform X2

    6. XM_047419814.1XP_047275770.1  zinc finger protein 273 isoform X2

    7. XM_047419806.1XP_047275762.1  zinc finger protein 273 isoform X2

    8. XM_047419817.1XP_047275773.1  zinc finger protein 273 isoform X2

    9. XM_047419821.1XP_047275777.1  zinc finger protein 273 isoform X2

    10. XM_047419804.1XP_047275760.1  zinc finger protein 273 isoform X2

    11. XM_047419818.1XP_047275774.1  zinc finger protein 273 isoform X2

    12. XM_024446635.2XP_024302403.1  zinc finger protein 273 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:126472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:132
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    13. XM_047419810.1XP_047275766.1  zinc finger protein 273 isoform X2

    14. XM_047419807.1XP_047275763.1  zinc finger protein 273 isoform X2

    15. XM_047419819.1XP_047275775.1  zinc finger protein 273 isoform X2

    16. XM_047419815.1XP_047275771.1  zinc finger protein 273 isoform X2

    17. XM_047419822.1XP_047275778.1  zinc finger protein 273 isoform X2

    18. XM_047419811.1XP_047275767.1  zinc finger protein 273 isoform X2

    19. XM_047419802.1XP_047275758.1  zinc finger protein 273 isoform X2

    20. XM_047419808.1XP_047275764.1  zinc finger protein 273 isoform X2

    21. XM_047419801.1XP_047275757.1  zinc finger protein 273 isoform X2

    22. XM_047419805.1XP_047275761.1  zinc finger protein 273 isoform X2

    23. XM_047419816.1XP_047275772.1  zinc finger protein 273 isoform X2

    24. XM_047419820.1XP_047275776.1  zinc finger protein 273 isoform X2

    25. XM_047419799.1XP_047275755.1  zinc finger protein 273 isoform X1

    RNA

    1. XR_007059982.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      66083757..66137245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357132.1XP_054213107.1  zinc finger protein 273 isoform X2

    2. XM_054357126.1XP_054213101.1  zinc finger protein 273 isoform X2

    3. XM_054357133.1XP_054213108.1  zinc finger protein 273 isoform X2

    4. XM_054357130.1XP_054213105.1  zinc finger protein 273 isoform X2

    5. XM_054357138.1XP_054213113.1  zinc finger protein 273 isoform X2

    6. XM_054357134.1XP_054213109.1  zinc finger protein 273 isoform X2

    7. XM_054357127.1XP_054213102.1  zinc finger protein 273 isoform X2

    8. XM_054357125.1XP_054213100.1  zinc finger protein 273 isoform X2

    9. XM_054357131.1XP_054213106.1  zinc finger protein 273 isoform X2

    10. XM_054357129.1XP_054213104.1  zinc finger protein 273 isoform X2

    11. XM_054357137.1XP_054213112.1  zinc finger protein 273 isoform X2

    12. XM_054357136.1XP_054213111.1  zinc finger protein 273 isoform X2

    13. XM_054357135.1XP_054213110.1  zinc finger protein 273 isoform X2

    14. XM_054357139.1XP_054213114.1  zinc finger protein 273 isoform X2

    15. XM_054357128.1XP_054213103.1  zinc finger protein 273 isoform X2

    16. XM_054357124.1XP_054213099.1  zinc finger protein 273 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033548.1: Suppressed sequence

      Description
      NM_033548.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NR_003099.1: Suppressed sequence

      Description
      NR_003099.1: This RefSeq was removed because it is now thought that this transcript is protein coding.