Pak3 p21 (RAC1) activated kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pak3provided by RGD
Official Full Name: p21 (RAC1) activated kinase 3provided by RGD
Primary source: RGD:3251
See related: Ensembl:ENSRNOG00000004676 AllianceGenome:RGD:3251
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: beta-PAK
Summary: Enables GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Located in endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 136.9), Testes (RPKM 64.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq33

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (111912967..112171037)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (107116308..107374342)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (114784452..115042683)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

specific loss of PAK3 expression and pharmacological inhibition of PAK both disrupt activity-dependent phosphorylation of S863 in cortical neurons
Title: Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation.
Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts.
Title: p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.
PAK3 regulates activity-mediated rearrangement of synaptic connectivity associated with learning, suggesting that defects in spine formation and refinement during development could account for intellectual disability.
Title: Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
While PAK1 and PAK3 share distinct roles in the regulation of spine morphogenesis, their activity may overlap, allowing compensation of the PAK3 deficit by PAK1.
Title: Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis.
the Cdc42/PAK3 is a key module in dendritic spine formation and synaptic plasticity
Title: The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.
A normal signaling pathway mediated by the interaction of amyloid precursor protein [APP], PAK3, and heterotrimeric Go protein is constitutively activated in neurons by familial Alzheimer mutations in APP causing cell cycle entry and consequent apoptosis
Title: DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.
Antisense and small interfering RNA-mediated suppression of PAK3 in rat hippocampal organotypic slice cultures results in the formation of abnormally elongated dendritic spines and filopodia-like protrusions and a decrease in mature spine synapses.
Title: The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

dxrat19 (e-PCR)
- UniSTS:120592

U39738 (e-PCR)
- UniSTS:125742

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 3

Names: PAK-3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p65-PAK

NP_062083.1

EC 2.7.11.1

XP_006257395.1

EC 2.7.11.1

XP_006257401.1

EC 2.7.11.1

XP_008771626.1

EC 2.7.11.1

XP_017457426.1

EC 2.7.11.1

XP_017457428.1

EC 2.7.11.1

XP_017457429.1

EC 2.7.11.1

XP_017457431.1

EC 2.7.11.1

XP_038955465.1

EC 2.7.11.1

XP_063135912.1

EC 2.7.11.1

XP_063135913.1

EC 2.7.11.1

XP_063135914.1

EC 2.7.11.1

XP_063135915.1

EC 2.7.11.1

XP_063135916.1

EC 2.7.11.1

XP_063135917.1

EC 2.7.11.1

XP_063135918.1

EC 2.7.11.1

XP_063135919.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019210.2 → NP_062083.1 serine/threonine-protein kinase PAK 3

See identical proteins and their annotated locations for NP_062083.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q62829

UniProtKB/TrEMBL

A0A8I5ZSQ0, A6KG82

Related

ENSRNOP00000006459.4, ENSRNOT00000006459.6

Conserved Domains (3) summary

cd06656
Location:248 → 544

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

smart00220
Location:268 → 519

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00786
Location:69 → 124

PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

111912967..112171037

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279845.1 → XP_063135915.1 serine/threonine-protein kinase PAK 3 isoform X4

UniProtKB/Swiss-Prot

Q62829

UniProtKB/TrEMBL

A6KG82
XM_063279849.1 → XP_063135919.1 serine/threonine-protein kinase PAK 3 isoform X4

UniProtKB/Swiss-Prot

Q62829

UniProtKB/TrEMBL

A6KG82
XM_017601940.3 → XP_017457429.1 serine/threonine-protein kinase PAK 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSQ0

Conserved Domains (2) summary

cd06656
Location:284 → 580

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

pfam00786
Location:69 → 162

PBD; P21-Rho-binding domain
XM_063279842.1 → XP_063135912.1 serine/threonine-protein kinase PAK 3 isoform X2
XM_039099537.2 → XP_038955465.1 serine/threonine-protein kinase PAK 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSQ0

Conserved Domains (2) summary

cd06656
Location:284 → 580

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

pfam00786
Location:69 → 162

PBD; P21-Rho-binding domain
XM_063279843.1 → XP_063135913.1 serine/threonine-protein kinase PAK 3 isoform X3

UniProtKB/TrEMBL

A0A8L2RA18
XM_017601937.3 → XP_017457426.1 serine/threonine-protein kinase PAK 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSQ0

Conserved Domains (2) summary

cd06656
Location:284 → 580

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

pfam00786
Location:69 → 162

PBD; P21-Rho-binding domain
XM_008773404.4 → XP_008771626.1 serine/threonine-protein kinase PAK 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSQ0

Conserved Domains (2) summary

cd06656
Location:284 → 580

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

pfam00786
Location:69 → 162

PBD; P21-Rho-binding domain
XM_017601942.3 → XP_017457431.1 serine/threonine-protein kinase PAK 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSQ0

Conserved Domains (2) summary

cd06656
Location:284 → 580

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

pfam00786
Location:69 → 162

PBD; P21-Rho-binding domain
XM_006257333.5 → XP_006257395.1 serine/threonine-protein kinase PAK 3 isoform X3

See identical proteins and their annotated locations for XP_006257395.1

UniProtKB/TrEMBL

A0A8I5ZSQ0, A0A8L2RA18

Related

ENSRNOP00000075221.2

Conserved Domains (2) summary

cd06656
Location:263 → 559

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

pfam00786
Location:69 → 141

PBD; P21-Rho-binding domain
XM_063279848.1 → XP_063135918.1 serine/threonine-protein kinase PAK 3 isoform X4

UniProtKB/Swiss-Prot

Q62829

UniProtKB/TrEMBL

A6KG82
XM_006257339.5 → XP_006257401.1 serine/threonine-protein kinase PAK 3 isoform X4

See identical proteins and their annotated locations for XP_006257401.1

UniProtKB/Swiss-Prot

Q62829

UniProtKB/TrEMBL

A0A8I5ZSQ0, A6KG82

Conserved Domains (3) summary

cd06656
Location:248 → 544

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

smart00220
Location:268 → 519

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00786
Location:69 → 124

PBD; P21-Rho-binding domain
XM_063279846.1 → XP_063135916.1 serine/threonine-protein kinase PAK 3 isoform X4

UniProtKB/Swiss-Prot

Q62829

UniProtKB/TrEMBL

A6KG82
XM_063279847.1 → XP_063135917.1 serine/threonine-protein kinase PAK 3 isoform X4

UniProtKB/Swiss-Prot

Q62829

UniProtKB/TrEMBL

A6KG82
XM_063279844.1 → XP_063135914.1 serine/threonine-protein kinase PAK 3 isoform X3

UniProtKB/TrEMBL

A0A8L2RA18
XM_017601939.3 → XP_017457428.1 serine/threonine-protein kinase PAK 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSQ0

Conserved Domains (2) summary

cd06656
Location:284 → 580

STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3

pfam00786
Location:69 → 162

PBD; P21-Rho-binding domain