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PAK3 p21 (RAC1) activated kinase 3 [ Homo sapiens (human) ]

Gene ID: 5063, updated on 25-Nov-2021

Summary

Official Symbol
PAK3provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 3provided by HGNC
Primary source
HGNC:HGNC:8592
See related
Ensembl:ENSG00000077264 MIM:300142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; XLID30; PAK3beta; beta-PAK
Summary
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Expression
Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues See more
Orthologs
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Genomic context

See PAK3 in Genome Data Viewer
Location:
Xq23
Exon count:
29
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (110944324..111227361)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (110187625..110470589)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene M6PR pseudogene 1 Neighboring gene chordin like 1 Neighboring gene FCF1 pseudogene 4 Neighboring gene glutamate dehydrogenase 1 pseudogene 9 Neighboring gene calpain 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mental retardation 30, X-linked
MedGen: C0796237 OMIM: 300558 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2019-12-09)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated 2019-12-09)

ClinGen Genome Curation PagePubMed

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686E11117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic spine morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in synapse organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 3
Names
adriamycin resistance-associated
oligophrenin-3
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
NP_001121638.1
NP_001121639.1
NP_001121640.1
NP_001121644.1
NP_001121645.1
NP_001311254.1
NP_001311255.1
NP_001311256.1
NP_001311257.1
NP_001311258.1
NP_001311259.1
NP_001311260.1
NP_001311261.1
NP_001311262.1
NP_001311263.1
NP_002569.1
XP_005262189.1
XP_005262190.1
XP_006724717.1
XP_006724718.1
XP_011529264.1
XP_011529269.1
XP_011529270.1
XP_011529271.1
XP_011529273.1
XP_016885046.1
XP_016885047.1
XP_016885048.1
XP_016885049.1
XP_016885050.1
XP_016885051.1
XP_016885052.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008288.2 RefSeqGene

    Range
    156907..288077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128166.3NP_001121638.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121638.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AK315284, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000410853.1, ENST00000446737.5
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  2. NM_001128167.3NP_001121639.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121639.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000401982.1, ENST00000425146.5
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  3. NM_001128168.3NP_001121640.1  serine/threonine-protein kinase PAK 3 isoform b

    See identical proteins and their annotated locations for NP_001121640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and contains two alternate in-frame exons compared to variant 1. The encoded isoform (b, also known as ab) is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48151.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000353864.4, ENST00000360648.8
    Conserved Domains (2) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69162
    PBD; P21-Rho-binding domain
  4. NM_001128172.2NP_001121644.1  serine/threonine-protein kinase PAK 3 isoform c

    See identical proteins and their annotated locations for NP_001121644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter 5' UTR and contains an alternate in-frame exon compared to variant 1. It encodes isoform c which is longer than isoform a.
    Source sequence(s)
    AK290504, AL031117, AM943852, BC117353, DB563607
    Consensus CDS
    CCDS48152.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000389172.1, ENST00000417227.5
    Conserved Domains (2) summary
    cd06656
    Location:269565
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69147
    PBD; P21-Rho-binding domain
  5. NM_001128173.3NP_001121645.1  serine/threonine-protein kinase PAK 3 isoform d

    See identical proteins and their annotated locations for NP_001121645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and contains alternate in-frame exon compared to variant 1. It encodes isoform d (also known as b) which is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  6. NM_001324325.2NP_001311254.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  7. NM_001324326.2NP_001311255.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  8. NM_001324327.2NP_001311256.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  9. NM_001324328.2NP_001311257.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000262836.4, ENST00000262836.6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  10. NM_001324329.2NP_001311258.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000361080.1, ENST00000372010.5
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  11. NM_001324330.2NP_001311259.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  12. NM_001324331.2NP_001311260.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  13. NM_001324332.2NP_001311261.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  14. NM_001324333.2NP_001311262.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  15. NM_001324334.2NP_001311263.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  16. NM_002578.5NP_002569.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_002569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AK290504, AL031117, BC117353, DA022842, DA957724, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000361077.4, ENST00000372007.10
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain

RNA

  1. NR_136740.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  2. NR_136741.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  3. NR_136742.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  4. NR_136743.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  5. NR_136744.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  6. NR_136745.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  7. NR_136746.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  8. NR_136747.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) represents use of an alternate promoter and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
  9. NR_136748.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is shorter at the 5' end and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL357774, BC143544

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    110944324..111227361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029557.1XP_016885046.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  2. XM_011530969.1XP_011529271.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529271.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  3. XM_017029559.1XP_016885048.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  4. XM_011530968.2XP_011529270.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529270.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  5. XM_017029561.2XP_016885050.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  6. XM_011530967.2XP_011529269.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529269.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  7. XM_006724655.2XP_006724718.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724718.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  8. XM_017029560.1XP_016885049.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  9. XM_017029563.1XP_016885052.1  serine/threonine-protein kinase PAK 3 isoform X7

    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000428921.1, ENST00000518291.5
    Conserved Domains (2) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69162
    PBD; P21-Rho-binding domain
  10. XM_017029562.1XP_016885051.1  serine/threonine-protein kinase PAK 3 isoform X5

  11. XM_005262132.2XP_005262189.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_005262189.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  12. XM_005262133.3XP_005262190.1  serine/threonine-protein kinase PAK 3 isoform X3

    See identical proteins and their annotated locations for XP_005262190.1

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  13. XM_011530971.2XP_011529273.1  serine/threonine-protein kinase PAK 3 isoform X6

    Conserved Domains (2) summary
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
    cl21453
    Location:262292
    PKc_like; Protein Kinases, catalytic domain
  14. XM_011530962.1XP_011529264.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529264.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  15. XM_006724654.2XP_006724717.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724717.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  16. XM_017029558.1XP_016885047.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
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