Format

Send to:

Choose Destination

PAK3 p21 (RAC1) activated kinase 3 [ Homo sapiens (human) ]

Gene ID: 5063, updated on 3-Jun-2018
Official Symbol
PAK3provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 3provided by HGNC
Primary source
HGNC:HGNC:8592
See related
Ensembl:ENSG00000077264 MIM:300142; Vega:OTTHUMG00000022202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta; beta-PAK
Summary
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Expression
Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues See more
Orthologs
See PAK3 in Genome Data Viewer
Location:
Xq23
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (110944241..111227361)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (110187513..110470590)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene mannose-6-phosphate receptor, cation dependent pseudogene Neighboring gene chordin like 1 Neighboring gene FCF1 pseudogene 4 Neighboring gene glutamate dehydrogenase 1 pseudogene 9 Neighboring gene calpain 6

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Mental retardation 30, X-linked
MedGen: C0796237 OMIM: 300558 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-05-10)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated (2012-05-10)

ClinGen Genome Curation PagePubMed
  • Activation of Rac, organism-specific biosystem (from REACTOME)
    Activation of Rac, organism-specific biosystemA low level of Rac activity is essential to maintain axon outgrowth and Robo activation recruits Sos, a dual specificity GEF to the plasma membrane via Dock to activate Rac during midline repulsion.
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
    C-type lectin receptors (CLRs), organism-specific biosystemPathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised ...
  • CD209 (DC-SIGN) signaling, organism-specific biosystem (from REACTOME)
    CD209 (DC-SIGN) signaling, organism-specific biosystemCD209 (also called as DC-SIGN (DC-specific intracellular adhesion molecule-3-grabbing non-integrin)) is a type II transmembrane C-type lectin receptor preferentially expressed on dendritic cells (DCs...
  • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
    CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
  • CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
    CD28 dependent Vav1 pathway, organism-specific biosystemCD28 binds to several intracellular proteins including PI3 kinase, Grb-2, Gads and ITK. Grb-2 specifically co-operates with Vav-1 in the up-regulation of NFAT/AP-1 transcription. CD28 costimulation r...
  • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
    Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • Ephrin signaling, organism-specific biosystem (from REACTOME)
    Ephrin signaling, organism-specific biosystemThe interaction between ephrin (EFN) ligands and EPH receptors results not only in forward signaling through the EPH receptor, but also in 'reverse' signaling through the EFN ligand itself. Reverse s...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
  • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
    Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Regulation of p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of p38-alpha and p38-beta, organism-specific biosystem
    Regulation of p38-alpha and p38-beta
  • Renal cell carcinoma, organism-specific biosystem (from KEGG)
    Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Renal cell carcinoma, conserved biosystem (from KEGG)
    Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
    Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • TCR signaling, organism-specific biosystem (from REACTOME)
    TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686E11117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Rac GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine morphogenesis TAS
Traceable Author Statement
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
synapse organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
serine/threonine-protein kinase PAK 3
Names
adriamycin resistance-associated
oligophrenin-3
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
NP_001121638.1
NP_001121639.1
NP_001121640.1
NP_001121644.1
NP_001121645.1
NP_001311254.1
NP_001311255.1
NP_001311256.1
NP_001311257.1
NP_001311258.1
NP_001311259.1
NP_001311260.1
NP_001311261.1
NP_001311262.1
NP_001311263.1
NP_002569.1
XP_005262189.1
XP_005262190.1
XP_006724717.1
XP_006724718.1
XP_011529264.1
XP_011529269.1
XP_011529270.1
XP_011529271.1
XP_011529273.1
XP_016885046.1
XP_016885047.1
XP_016885048.1
XP_016885049.1
XP_016885050.1
XP_016885051.1
XP_016885052.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008288.2 RefSeqGene

    Range
    156858..288077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128166.2NP_001121638.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121638.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AK315284, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000410853.1, ENST00000446737.5
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  2. NM_001128167.2NP_001121639.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121639.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000401982.1, ENST00000425146.5
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  3. NM_001128168.2NP_001121640.1  serine/threonine-protein kinase PAK 3 isoform b

    See identical proteins and their annotated locations for NP_001121640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and contains two alternate in-frame exons compared to variant 1. The encoded isoform (b, also known as ab) is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48151.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69162
    PBD; P21-Rho-binding domain
  4. NM_001128172.2NP_001121644.1  serine/threonine-protein kinase PAK 3 isoform c

    See identical proteins and their annotated locations for NP_001121644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter 5' UTR and contains an alternate in-frame exon compared to variant 1. It encodes isoform c which is longer than isoform a.
    Source sequence(s)
    AK290504, AL031117, AM943852, BC117353, DB563607
    Consensus CDS
    CCDS48152.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000389172.1, ENST00000417227.5
    Conserved Domains (2) summary
    cd06656
    Location:269565
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69147
    PBD; P21-Rho-binding domain
  5. NM_001128173.2NP_001121645.1  serine/threonine-protein kinase PAK 3 isoform d

    See identical proteins and their annotated locations for NP_001121645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and contains alternate in-frame exon compared to variant 1. It encodes isoform d (also known as b) which is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  6. NM_001324325.1NP_001311254.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  7. NM_001324326.1NP_001311255.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  8. NM_001324327.1NP_001311256.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  9. NM_001324328.1NP_001311257.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000262836.4, ENST00000262836.6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  10. NM_001324329.1NP_001311258.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000361080.1, OTTHUMP00000023856, ENST00000372010.5, OTTHUMT00000057918
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  11. NM_001324330.1NP_001311259.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  12. NM_001324331.1NP_001311260.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  13. NM_001324332.1NP_001311261.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  14. NM_001324333.1NP_001311262.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  15. NM_001324334.1NP_001311263.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  16. NM_002578.4NP_002569.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_002569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AK290504, AL031117, BC117353, DA022842, DA957724, DB053586, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000361077.4, OTTHUMP00000023855, ENST00000372007.9, OTTHUMT00000057917
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain

RNA

  1. NR_136740.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  2. NR_136741.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  3. NR_136742.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  4. NR_136743.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  5. NR_136744.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  6. NR_136745.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  7. NR_136746.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  8. NR_136747.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) represents use of an alternate promoter and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
  9. NR_136748.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is shorter at the 5' end and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL357774, BC143544

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    110944241..111227361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029557.1XP_016885046.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  2. XM_011530969.1XP_011529271.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529271.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  3. XM_017029559.1XP_016885048.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  4. XM_011530968.2XP_011529270.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529270.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  5. XM_017029561.2XP_016885050.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/Swiss-Prot
    O75914
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  6. XM_011530967.2XP_011529269.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529269.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  7. XM_006724655.2XP_006724718.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724718.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  8. XM_017029560.1XP_016885049.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  9. XM_017029563.1XP_016885052.1  serine/threonine-protein kinase PAK 3 isoform X7

    UniProtKB/Swiss-Prot
    O75914
    Related
    ENSP00000428921.1, OTTHUMP00000226622, ENST00000518291.5, OTTHUMT00000378588
    Conserved Domains (2) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69162
    PBD; P21-Rho-binding domain
  10. XM_017029562.1XP_016885051.1  serine/threonine-protein kinase PAK 3 isoform X5

  11. XM_005262132.2XP_005262189.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_005262189.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  12. XM_005262133.3XP_005262190.1  serine/threonine-protein kinase PAK 3 isoform X3

    See identical proteins and their annotated locations for XP_005262190.1

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  13. XM_011530971.2XP_011529273.1  serine/threonine-protein kinase PAK 3 isoform X6

    Conserved Domains (2) summary
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
    cl21453
    Location:262292
    PKc_like; Protein Kinases, catalytic domain
  14. XM_011530962.1XP_011529264.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529264.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  15. XM_006724654.2XP_006724717.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724717.1

    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  16. XM_017029558.1XP_016885047.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
Support Center