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Pak3 p21 (RAC1) activated kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 18481, updated on 20-May-2024

Summary

Official Symbol
Pak3provided by MGI
Official Full Name
p21 (RAC1) activated kinase 3provided by MGI
Primary source
MGI:MGI:1339656
See related
Ensembl:ENSMUSG00000031284 AllianceGenome:MGI:1339656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stk4; PAK-3; Pak65beta; Pak65alpha
Summary
Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis and dendritic spine morphogenesis. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; gonad; liver; lung; and retina. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 8.0), whole brain E14.5 (RPKM 6.4) and 8 other tissues See more
Orthologs
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Genomic context

See Pak3 in Genome Data Viewer
Location:
X F2; X 64.5 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (142301370..142580792)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (143518366..143797796)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene chordin-like 1 Neighboring gene predicted gene, 23325 Neighboring gene STARR-seq mESC enhancer starr_48031 Neighboring gene calpain 6 Neighboring gene doublecortin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IC
Inferred by Curator
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 3
Names
CDC42/RAC effector kinase PAK-B
beta-PAK
p21 protein (Cdc42/Rac)-activated kinase 3
p21-activated kinase 3
NP_001181975.1
NP_001181976.1
NP_001181977.1
NP_001181978.1
NP_032804.2
XP_006528815.1
XP_006528816.1
XP_006528817.1
XP_011246092.1
XP_030107108.1
XP_030107109.1
XP_030107110.1
XP_030107111.1
XP_036017734.1
XP_036017735.1
XP_036017736.1
XP_036017737.1
XP_036017738.1
XP_036017739.1
XP_036017740.1
XP_036017741.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195046.1NP_001181975.1  serine/threonine-protein kinase PAK 3 isoform A

    See identical proteins and their annotated locations for NP_001181975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (A).
    Source sequence(s)
    AL691499, BX530055, BX813331
    UniProtKB/TrEMBL
    B1GX81
    Conserved Domains (2) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    cd01093
    Location:68149
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_001195047.1NP_001181976.1  serine/threonine-protein kinase PAK 3 isoform B

    See identical proteins and their annotated locations for NP_001181976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AL691499, BX530055, BX813331
    UniProtKB/TrEMBL
    B1GX80
    Conserved Domains (3) summary
    cd06656
    Location:269565
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    smart00220
    Location:289540
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:69145
    PBD; P21-Rho-binding domain
  3. NM_001195048.1NP_001181977.1  serine/threonine-protein kinase PAK 3 isoform C

    See identical proteins and their annotated locations for NP_001181977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform C), compared to isoform A.
    Source sequence(s)
    AK158893, AL691499, BX530055, BX813331
    Consensus CDS
    CCDS57779.1
    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Related
    ENSMUSP00000033640.8, ENSMUST00000033640.14
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  4. NM_001195049.1NP_001181978.1  serine/threonine-protein kinase PAK 3 isoform D

    See identical proteins and their annotated locations for NP_001181978.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks two consecutive in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform D), compared to isoform A. Both variants 4 and 5 encode the same protein (isoform D).
    Source sequence(s)
    AL691499, BX530055, BX813331
    Consensus CDS
    CCDS30454.1
    UniProtKB/Swiss-Prot
    Q61036
    Related
    ENSMUSP00000108485.2, ENSMUST00000112864.8
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  5. NM_008778.3NP_032804.2  serine/threonine-protein kinase PAK 3 isoform D

    See identical proteins and their annotated locations for NP_032804.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks two consecutive in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform D), compared to isoform A. Both variants 4 and 5 encode the same protein (isoform D).
    Source sequence(s)
    AL691499, BX322533, BX530055, BX813331
    Consensus CDS
    CCDS30454.1
    UniProtKB/Swiss-Prot
    Q61036
    Related
    ENSMUSP00000126562.3, ENSMUST00000172330.3
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    142301370..142580792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161842.1XP_036017735.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  2. XM_036161844.1XP_036017737.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  3. XM_036161841.1XP_036017734.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  4. XM_036161846.1XP_036017739.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  5. XM_036161847.1XP_036017740.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  6. XM_011247790.4XP_011246092.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_011246092.1

    UniProtKB/Swiss-Prot
    Q61036
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  7. XM_030251249.2XP_030107109.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  8. XM_036161843.1XP_036017736.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Related
    ENSMUSP00000108484.2, ENSMUST00000112863.8
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  9. XM_030251248.2XP_030107108.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  10. XM_006528752.5XP_006528815.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006528815.1

    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  11. XM_030251251.2XP_030107111.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  12. XM_006528753.4XP_006528816.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_006528816.1

    UniProtKB/Swiss-Prot
    Q61036
    Related
    ENSMUSP00000108486.2, ENSMUST00000112865.8
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  13. XM_006528754.5XP_006528817.1  serine/threonine-protein kinase PAK 3 isoform X2

    See identical proteins and their annotated locations for XP_006528817.1

    UniProtKB/Swiss-Prot
    Q61036
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  14. XM_036161845.1XP_036017738.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/Swiss-Prot
    O88645, Q61036, Q8K1R5, Q8K1R6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  15. XM_030251250.2XP_030107110.1  serine/threonine-protein kinase PAK 3 isoform X2

    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  16. XM_036161848.1XP_036017741.1  serine/threonine-protein kinase PAK 3 isoform X3

    Conserved Domains (1) summary
    cd06656
    Location:230526
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3