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    STMN1 stathmin 1 [ Homo sapiens (human) ]

    Gene ID: 3925, updated on 4-Oct-2020

    Summary

    Official Symbol
    STMN1provided by HGNC
    Official Full Name
    stathmin 1provided by HGNC
    Primary source
    HGNC:HGNC:6510
    See related
    Ensembl:ENSG00000117632 MIM:151442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
    Summary
    This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
    Expression
    Broad expression in brain (RPKM 118.2), testis (RPKM 64.4) and 20 other tissues See more
    Orthologs

    Genomic context

    See STMN1 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (25884179..25906880, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26210670..26233368, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial fission regulator 1 like Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene Sharpr-MPRA regulatory region 13744 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 7 Neighboring gene uncharacterized LOC105376885 Neighboring gene microRNA 3917 Neighboring gene CRISPRi-validated cis-regulatory element chr1.3691 Neighboring gene RNA, U6 small nuclear 110, pseudogene Neighboring gene platelet activating factor acetylhydrolase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies STMN1, a factor involved in microtubule organization, as IN-binding partner PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ32206, MGC138869, MGC138870

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of thrombin-activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cellular component movement IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of microtubule polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    stathmin
    Names
    leukemia-associated phosphoprotein p18
    metablastin
    oncoprotein 18
    phosphoprotein 19
    phosphoprotein p19
    prosolin
    stathmin 1/oncoprotein 18
    testicular tissue protein Li 189
    transmembrane protein C1orf215

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145454.3NP_001138926.1  stathmin isoform b

      See identical proteins and their annotated locations for NP_001138926.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript, and encodes the longer isoform (b).
      Source sequence(s)
      AK303692, AL033528, BC028398, BG493669
      Consensus CDS
      CCDS44090.1
      UniProtKB/Swiss-Prot
      P16949
      UniProtKB/TrEMBL
      A0A140VJW2
      Related
      ENSP00000410452.2, ENST00000426559.6
      Conserved Domains (1) summary
      pfam00836
      Location:9126
      Stathmin; Stathmin family
    2. NM_005563.4NP_005554.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_005554.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, BG030679, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      P16949
      Related
      ENSP00000387858.2, ENST00000455785.7
      Conserved Domains (1) summary
      pfam00836
      Location:5139
      Stathmin; Stathmin family
    3. NM_203399.2NP_981944.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_981944.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, AL033528, BG030679, BM563894, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      P16949
      Related
      ENSP00000350531.2, ENST00000357865.6
      Conserved Domains (1) summary
      pfam00836
      Location:5139
      Stathmin; Stathmin family
    4. NM_203401.2NP_981946.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_981946.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, BG030679, BQ428400, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      P16949
      Related
      ENSP00000382633.1, ENST00000399728.5
      Conserved Domains (1) summary
      pfam00836
      Location:5139
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      25884179..25906880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152497.1: Suppressed sequence

      Description
      NM_152497.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Support Center