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Stmn1 stathmin 1 [ Mus musculus (house mouse) ]

Gene ID: 16765, updated on 8-Jan-2023

Summary

Official Symbol
Stmn1provided by MGI
Official Full Name
stathmin 1provided by MGI
Primary source
MGI:MGI:96739
See related
Ensembl:ENSMUSG00000028832 AllianceGenome:MGI:96739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
19k; Lag; P18; P19; Pig; Smn; Op18; Pp17; Pp18; Pp19; Pr22; Lap18
Summary
Predicted to enable tubulin binding activity. Acts upstream of or within several processes, including axonogenesis; mitotic cytokinesis; and negative regulation of microtubule polymerization. Located in cytosol and membrane. Is expressed in several structures, including genitourinary system; lung; nervous system; olfactory epithelium; and retina. Orthologous to human STMN1 (stathmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 553.0), CNS E14 (RPKM 443.2) and 11 other tissues See more
Orthologs
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Genomic context

See Stmn1 in Genome Data Viewer
Location:
4 D2.3; 4 66.76 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134195631..134201154)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134468320..134473843)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30453 Neighboring gene RIKEN cDNA 1700021N21 gene Neighboring gene ribosomal protein 10 pseudogene Neighboring gene progestin and adipoQ receptor family member VII

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of thrombin-activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
stathmin
Names
leukemia-associated gene protein
leukemia-associated phosphoprotein p18
metablastin
oncoprotein 18
oncoprotein18
phosphoprotein p19
prosolin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019641.4NP_062615.1  stathmin

    See identical proteins and their annotated locations for NP_062615.1

    Status: VALIDATED

    Source sequence(s)
    AL669982, BC031831
    Consensus CDS
    CCDS18772.1
    UniProtKB/Swiss-Prot
    P54227
    UniProtKB/TrEMBL
    A0A6P5PKA0, A0A8C6GA43, Q545B6
    Related
    ENSMUSP00000030636.5, ENSMUST00000030636.11
    Conserved Domains (1) summary
    pfam00836
    Location:5140
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134195631..134201154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)