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STMN1 stathmin 1 [ Homo sapiens (human) ]

Gene ID: 3925, updated on 11-Sep-2019

Summary

Official Symbol
STMN1provided by HGNC
Official Full Name
stathmin 1provided by HGNC
Primary source
HGNC:HGNC:6510
See related
Ensembl:ENSG00000117632 MIM:151442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
Summary
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Expression
Broad expression in brain (RPKM 118.2), testis (RPKM 64.4) and 20 other tissues See more
Orthologs

Genomic context

See STMN1 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (25884179..25906877, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26210670..26233368, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial fission regulator 1 like Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene Sharpr-MPRA regulatory region 13744 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 7 Neighboring gene uncharacterized LOC105376885 Neighboring gene microRNA 3917 Neighboring gene RNA, U6 small nuclear 110, pseudogene Neighboring gene platelet activating factor acetylhydrolase 2 Neighboring gene uncharacterized LOC101928216 Neighboring gene exostosin like glycosyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies STMN1, a factor involved in microtubule organization, as IN-binding partner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
    Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
  • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
    Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.
  • Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem
    Signaling mediated by p38-gamma and p38-delta

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32206, MGC138869, MGC138870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
tubulin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of thrombin-activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cellular component movement IEA
Inferred from Electronic Annotation
more info
 
regulation of cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
stathmin
Names
leukemia-associated phosphoprotein p18
metablastin
oncoprotein 18
phosphoprotein 19
phosphoprotein p19
prosolin
stathmin 1/oncoprotein 18
testicular tissue protein Li 189
transmembrane protein C1orf215

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145454.3NP_001138926.1  stathmin isoform b

    See identical proteins and their annotated locations for NP_001138926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript, and encodes the longer isoform (b).
    Source sequence(s)
    AK303692, AL033528, BC028398, BG493669
    Consensus CDS
    CCDS44090.1
    UniProtKB/Swiss-Prot
    P16949
    UniProtKB/TrEMBL
    A0A140VJW2
    Related
    ENSP00000410452.2, ENST00000426559.6
    Conserved Domains (1) summary
    pfam00836
    Location:9126
    Stathmin; Stathmin family
  2. NM_005563.4NP_005554.1  stathmin isoform a

    See identical proteins and their annotated locations for NP_005554.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK054594, BG030679, BQ772197
    Consensus CDS
    CCDS269.1
    UniProtKB/Swiss-Prot
    P16949
    Related
    ENSP00000387858.2, ENST00000455785.7
    Conserved Domains (1) summary
    pfam00836
    Location:5140
    Stathmin; Stathmin family
  3. NM_203399.1NP_981944.1  stathmin isoform a

    See identical proteins and their annotated locations for NP_981944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK054594, BG030679, BM563894, BQ772197
    Consensus CDS
    CCDS269.1
    UniProtKB/Swiss-Prot
    P16949
    Related
    ENSP00000350531.2, ENST00000357865.6
    Conserved Domains (1) summary
    pfam00836
    Location:5140
    Stathmin; Stathmin family
  4. NM_203401.1NP_981946.1  stathmin isoform a

    See identical proteins and their annotated locations for NP_981946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK054594, BG030679, BQ428400, BQ772197
    Consensus CDS
    CCDS269.1
    UniProtKB/Swiss-Prot
    P16949
    Related
    ENSP00000382633.1, ENST00000399728.5
    Conserved Domains (1) summary
    pfam00836
    Location:5140
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    25884179..25906877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152497.1: Suppressed sequence

    Description
    NM_152497.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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