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RO60 Ro60, Y RNA binding protein [ Homo sapiens (human) ]

Gene ID: 6738, updated on 12-May-2019

Summary

Official Symbol
RO60provided by HGNC
Official Full Name
Ro60, Y RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:11313
See related
Ensembl:ENSG00000116747 MIM:600063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSA2; RORNP; TROVE2
Expression
Ubiquitous expression in brain (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See RO60 in Genome Data Viewer
Location:
1q31.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (193059422..193091777)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (193028552..193060907)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 101 pseudogene 2 Neighboring gene ubiquitin C-terminal hydrolase L5 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene uncharacterized LOC101929160 Neighboring gene glutaredoxin 2 Neighboring gene cell division cycle 73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
    Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
  • Systemic lupus erythematosus, conserved biosystem (from KEGG)
    Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
U2 snRNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
immune system development IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
response to UV IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase III TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60 kDa SS-A/Ro ribonucleoprotein
Names
60 kDa ribonucleoprotein Ro
Ro/SSA 60kDa
Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro)
TROVE domain family member 2
gastric cancer multi-drug resistance protein
ro60 autoantigen
sjoegren syndrome type A antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042369.2NP_001035828.1  60 kDa SS-A/Ro ribonucleoprotein isoform 1

    See identical proteins and their annotated locations for NP_001035828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI433657, CX761715, M25077
    Consensus CDS
    CCDS41449.1
    UniProtKB/Swiss-Prot
    P10155
    Related
    ENSP00000356414.3, ENST00000367444.7
    Conserved Domains (2) summary
    pfam05731
    Location:17369
    TROVE; TROVE domain
    cl00057
    Location:370505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_001042370.2NP_001035829.2  60 kDa SS-A/Ro ribonucleoprotein isoform 3

    See identical proteins and their annotated locations for NP_001035829.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI433657, AL136370, AY205315, CX761715
    Consensus CDS
    CCDS41450.2
    UniProtKB/Swiss-Prot
    P10155
    Related
    ENSP00000356415.3, ENST00000367445.7
    Conserved Domains (2) summary
    pfam05731
    Location:17369
    TROVE; TROVE domain
    cl00057
    Location:370505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. NM_001173524.1NP_001166995.1  60 kDa SS-A/Ro ribonucleoprotein isoform 2

    See identical proteins and their annotated locations for NP_001166995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, the 3' coding region and the 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1. Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AK314594, AL136370, BC036658, DA518443, M25077
    Consensus CDS
    CCDS1379.1
    UniProtKB/Swiss-Prot
    P10155
    UniProtKB/TrEMBL
    A0A024R983
    Related
    ENSP00000383752.2, ENST00000400968.6
    Conserved Domains (2) summary
    cd00198
    Location:372489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:17369
    TROVE; TROVE domain
  4. NM_001173525.1NP_001166996.1  60 kDa SS-A/Ro ribonucleoprotein isoform 4

    See identical proteins and their annotated locations for NP_001166996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI433657, AL136370, AY205314, CX761715
    Consensus CDS
    CCDS53451.1
    UniProtKB/Swiss-Prot
    P10155
    Related
    ENSP00000356413.1, ENST00000367443.5
    Conserved Domains (2) summary
    pfam05731
    Location:17369
    TROVE; TROVE domain
    cl00057
    Location:370505
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  5. NM_001331020.1NP_001317949.1  60 kDa SS-A/Ro ribonucleoprotein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL136370
    Consensus CDS
    CCDS86042.1
    UniProtKB/TrEMBL
    G5E9R9
    Related
    ENSP00000472298.1, ENST00000432079.5
    Conserved Domains (2) summary
    cd00198
    Location:97214
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:194
    TROVE; TROVE domain
  6. NM_004600.5NP_004591.2  60 kDa SS-A/Ro ribonucleoprotein isoform 2

    See identical proteins and their annotated locations for NP_004591.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL136370, BC036658, CX761715
    Consensus CDS
    CCDS1379.1
    UniProtKB/Swiss-Prot
    P10155
    UniProtKB/TrEMBL
    A0A024R983
    Related
    ENSP00000356416.3, ENST00000367446.7
    Conserved Domains (2) summary
    cd00198
    Location:372489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:17369
    TROVE; TROVE domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    193059422..193091777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002183.1XP_016857672.1  60 kDa SS-A/Ro ribonucleoprotein isoform X3

    UniProtKB/TrEMBL
    G5E9R9
    Conserved Domains (2) summary
    cd00198
    Location:97214
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:194
    TROVE; TROVE domain
  2. XM_006711495.4XP_006711558.1  60 kDa SS-A/Ro ribonucleoprotein isoform X1

    See identical proteins and their annotated locations for XP_006711558.1

    Conserved Domains (2) summary
    pfam05731
    Location:17391
    TROVE; TROVE domain
    cl00057
    Location:392527
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. XM_017002181.2XP_016857670.1  60 kDa SS-A/Ro ribonucleoprotein isoform X2

    UniProtKB/Swiss-Prot
    P10155
    UniProtKB/TrEMBL
    A0A024R983
    Conserved Domains (2) summary
    cd00198
    Location:372489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:17369
    TROVE; TROVE domain
  4. XM_006711496.3XP_006711559.1  60 kDa SS-A/Ro ribonucleoprotein isoform X1

    See identical proteins and their annotated locations for XP_006711559.1

    Conserved Domains (2) summary
    pfam05731
    Location:17391
    TROVE; TROVE domain
    cl00057
    Location:392527
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  5. XM_006711497.3XP_006711560.1  60 kDa SS-A/Ro ribonucleoprotein isoform X2

    See identical proteins and their annotated locations for XP_006711560.1

    UniProtKB/Swiss-Prot
    P10155
    UniProtKB/TrEMBL
    A0A024R983
    Conserved Domains (2) summary
    cd00198
    Location:372489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:17369
    TROVE; TROVE domain
  6. XM_011509922.2XP_011508224.1  60 kDa SS-A/Ro ribonucleoprotein isoform X3

    See identical proteins and their annotated locations for XP_011508224.1

    UniProtKB/TrEMBL
    G5E9R9
    Conserved Domains (2) summary
    cd00198
    Location:97214
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:194
    TROVE; TROVE domain
  7. XM_017002180.1XP_016857669.1  60 kDa SS-A/Ro ribonucleoprotein isoform X1

    Conserved Domains (2) summary
    pfam05731
    Location:17391
    TROVE; TROVE domain
    cl00057
    Location:392527
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  8. XM_017002182.1XP_016857671.1  60 kDa SS-A/Ro ribonucleoprotein isoform X2

    UniProtKB/Swiss-Prot
    P10155
    UniProtKB/TrEMBL
    A0A024R983
    Conserved Domains (2) summary
    cd00198
    Location:372489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:17369
    TROVE; TROVE domain
  9. XM_024449332.1XP_024305100.1  60 kDa SS-A/Ro ribonucleoprotein isoform X2

    Conserved Domains (2) summary
    cd00198
    Location:372489
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam05731
    Location:17369
    TROVE; TROVE domain
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