npas1 neuronal PAS domain protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: npas1provided by ZNC
Official Full Name: neuronal PAS domain protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-934
See related: Ensembl:ENSDARG00000015876 AllianceGenome:ZFIN:ZDB-GENE-060503-934
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: npas3b; si:dkeyp-13e2.1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Orthologous to human NPAS1 (neuronal PAS domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (8425662..8517376, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (8449591..8541305, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G40747 (e-PCR)
- UniSTS:58015

z9214 (e-PCR), detects polymorphism
- UniSTS:205003

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal PAS domain-containing protein 1

Names: neuronal PAS domain protein 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328383.1 → NP_001315312.1 neuronal PAS domain-containing protein 1

Status: VALIDATED

Source sequence(s)

BX296539

UniProtKB/TrEMBL

A0A2R8Q2I0, A0A8M1P3S8

Related

ENSDARP00000146804.1, ENSDART00000186289.1

Conserved Domains (5) summary

smart00091
Location:130 → 188

PAS; PAS domain

cd00083
Location:37 → 94

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:307 → 401

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:131 → 188

PAS; PAS fold

pfam14598
Location:310 → 414

PAS_11; PAS domain