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NPAS1 neuronal PAS domain protein 1 [ Homo sapiens (human) ]

Gene ID: 4861, updated on 1-Aug-2020

Summary

Official Symbol
NPAS1provided by HGNC
Official Full Name
neuronal PAS domain protein 1provided by HGNC
Primary source
HGNC:HGNC:7894
See related
Ensembl:ENSG00000130751 MIM:603346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOP5; PASD5; bHLHe11
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.1), stomach (RPKM 0.8) and 8 other tissues See more
Orthologs

Genomic context

See NPAS1 in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47019837..47045775)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47523077..47549033)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit sigma 1 Neighboring gene Rho GTPase activating protein 35 Neighboring gene Sharpr-MPRA regulatory region 8906 Neighboring gene transmembrane protein 160

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
startle response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neuronal PAS domain-containing protein 1
Names
PAS domain-containing protein 5
basic-helix-loop-helix-PAS protein MOP5
class E basic helix-loop-helix protein 11
member of PAS protein 5
member of PAS superfamily 5
neuronal PAS1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321086.2NP_001308015.1  neuronal PAS domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008755, AK299128, BC039016
    Consensus CDS
    CCDS82371.1
    UniProtKB/Swiss-Prot
    Q99742
    Related
    ENSP00000398689.2, ENST00000439365.6
    Conserved Domains (1) summary
    smart00091
    Location:119178
    PAS; PAS domain
  2. NM_002517.4NP_002508.2  neuronal PAS domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_002508.2

    Status: REVIEWED

    Source sequence(s)
    AC008755, BC039016, CA420408
    Consensus CDS
    CCDS12694.1
    UniProtKB/Swiss-Prot
    Q99742
    Related
    ENSP00000469142.1, ENST00000602212.6
    Conserved Domains (3) summary
    smart00091
    Location:141198
    PAS; PAS domain
    cd00083
    Location:4596
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08447
    Location:315386
    PAS_3; PAS fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47019837..47045775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026844.1XP_016882333.1  neuronal PAS domain-containing protein 1 isoform X1

  2. XM_024451524.1XP_024307292.1  neuronal PAS domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam08447
    Location:189255
    PAS_3; PAS fold
  3. XM_024451525.1XP_024307293.1  neuronal PAS domain-containing protein 1 isoform X3

    Related
    ENSP00000472679.1, ENST00000602189.5
    Conserved Domains (1) summary
    smart00091
    Location:120179
    PAS; PAS domain
  4. XM_024451527.1XP_024307295.1  neuronal PAS domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    smart00091
    Location:119178
    PAS; PAS domain
  5. XM_024451526.1XP_024307294.1  neuronal PAS domain-containing protein 1 isoform X4

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