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NPAS1 neuronal PAS domain protein 1 [ Homo sapiens (human) ]

Gene ID: 4861, updated on 23-Nov-2023

Summary

Official Symbol
NPAS1provided by HGNC
Official Full Name
neuronal PAS domain protein 1provided by HGNC
Primary source
HGNC:HGNC:7894
See related
Ensembl:ENSG00000130751 MIM:603346; AllianceGenome:HGNC:7894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOP5; PASD5; bHLHe11
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.1), stomach (RPKM 0.8) and 8 other tissues See more
Orthologs
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Genomic context

See NPAS1 in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47019837..47045775)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49845776..49871084)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47523094..47549033)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47341466-47341966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47358600-47359538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47359539-47360475 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10833 Neighboring gene adaptor related protein complex 2 subunit sigma 1 Neighboring gene Rho GTPase activating protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10834 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:47466169-47467368 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47479369-47480226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47480227-47481082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47505718-47506463 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47506464-47507210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47508684-47509262 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47514658-47514871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10835 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47533967-47534068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47534993-47535494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10836 Neighboring gene Sharpr-MPRA regulatory region 8906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47552307-47552824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47552825-47553342 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47557751-47558307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47562983-47563503 Neighboring gene MPRA-validated peak3531 silencer Neighboring gene transmembrane protein 160 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47613025-47613752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47615210-47615938 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47615939-47616666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14858

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in central nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in maternal behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in startle response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuronal PAS domain-containing protein 1
Names
PAS domain-containing protein 5
basic-helix-loop-helix-PAS protein MOP5
class E basic helix-loop-helix protein 11
member of PAS protein 5
member of PAS superfamily 5
neuronal PAS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321086.2NP_001308015.1  neuronal PAS domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008755, AK299128, BC039016
    Consensus CDS
    CCDS82371.1
    UniProtKB/TrEMBL
    M0R1R8
    Related
    ENSP00000398689.2, ENST00000439365.6
    Conserved Domains (1) summary
    smart00091
    Location:119178
    PAS; PAS domain
  2. NM_002517.4NP_002508.2  neuronal PAS domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_002508.2

    Status: REVIEWED

    Source sequence(s)
    AC008755, BC039016, CA420408
    Consensus CDS
    CCDS12694.1
    UniProtKB/Swiss-Prot
    B4DR69, Q99632, Q99742, Q9BY83
    Related
    ENSP00000469142.1, ENST00000602212.6
    Conserved Domains (3) summary
    smart00091
    Location:141198
    PAS; PAS domain
    cd00083
    Location:4596
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08447
    Location:315386
    PAS_3; PAS fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    47019837..47045775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438882.1XP_047294838.1  neuronal PAS domain-containing protein 1 isoform X2

  2. XM_047438885.1XP_047294841.1  neuronal PAS domain-containing protein 1 isoform X7

  3. XM_047438881.1XP_047294837.1  neuronal PAS domain-containing protein 1 isoform X1

  4. XM_047438886.1XP_047294842.1  neuronal PAS domain-containing protein 1 isoform X8

  5. XM_024451526.2XP_024307294.2  neuronal PAS domain-containing protein 1 isoform X5

  6. XM_047438883.1XP_047294839.1  neuronal PAS domain-containing protein 1 isoform X3

  7. XM_017026844.2XP_016882333.1  neuronal PAS domain-containing protein 1 isoform X4

  8. XM_047438884.1XP_047294840.1  neuronal PAS domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    M0R2M8
  9. XM_047438887.1XP_047294843.1  neuronal PAS domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    M0R2M8
    Related
    ENSP00000472679.1, ENST00000602189.5
  10. XM_047438889.1XP_047294845.1  neuronal PAS domain-containing protein 1 isoform X11

  11. XM_047438888.1XP_047294844.1  neuronal PAS domain-containing protein 1 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49845776..49871084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321110.1XP_054177085.1  neuronal PAS domain-containing protein 1 isoform X2

  2. XM_054321115.1XP_054177090.1  neuronal PAS domain-containing protein 1 isoform X7

  3. XM_054321109.1XP_054177084.1  neuronal PAS domain-containing protein 1 isoform X1

  4. XM_054321111.1XP_054177086.1  neuronal PAS domain-containing protein 1 isoform X3

  5. XM_054321116.1XP_054177091.1  neuronal PAS domain-containing protein 1 isoform X8

  6. XM_054321113.1XP_054177088.1  neuronal PAS domain-containing protein 1 isoform X5

  7. XM_054321112.1XP_054177087.1  neuronal PAS domain-containing protein 1 isoform X4

  8. XM_054321114.1XP_054177089.1  neuronal PAS domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    M0R2M8
  9. XM_054321118.1XP_054177093.1  neuronal PAS domain-containing protein 1 isoform X10

  10. XM_054321117.1XP_054177092.1  neuronal PAS domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    M0R2M8
  11. XM_054321119.1XP_054177094.1  neuronal PAS domain-containing protein 1 isoform X11