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Npas1 neuronal PAS domain protein 1 [ Mus musculus (house mouse) ]

Gene ID: 18142, updated on 7-May-2024

Summary

Official Symbol
Npas1provided by MGI
Official Full Name
neuronal PAS domain protein 1provided by MGI
Primary source
MGI:MGI:109205
See related
Ensembl:ENSMUSG00000001988 AllianceGenome:MGI:109205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOP5; bHLHe11
Summary
Enables protein heterodimerization activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within maternal behavior; negative regulation of transcription by RNA polymerase II; and startle response. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and limb. Orthologous to human NPAS1 (neuronal PAS domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 4.5), cortex adult (RPKM 2.8) and 15 other tissues See more
Orthologs
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Genomic context

See Npas1 in Genome Data Viewer
Location:
7 A2; 7 9.14 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16189643..16210741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16455721..16476822, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18133 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E347 Neighboring gene transmembrane protein 160 Neighboring gene nuclear encoded rRNA 5S 151 Neighboring gene STARR-positive B cell enhancer ABC_E10425 Neighboring gene Rho GTPase activating protein 35 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 17981

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
neuronal PAS domain-containing protein 1
Names
neuronal PAS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417027.1NP_001403956.1  neuronal PAS domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164880
  2. NM_008718.2NP_032744.1  neuronal PAS domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_032744.1

    Status: VALIDATED

    Source sequence(s)
    AC164880, BC137863, BY279348
    Consensus CDS
    CCDS20850.1
    UniProtKB/Swiss-Prot
    P97459
    UniProtKB/TrEMBL
    A2RSH6
    Related
    ENSMUSP00000002053.9, ENSMUST00000002053.9
    Conserved Domains (3) summary
    smart00091
    Location:141198
    PAS; PAS domain
    pfam08447
    Location:316387
    PAS_3; PAS fold
    cd19731
    Location:43116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16189643..16210741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152765.1XP_036008658.1  neuronal PAS domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    smart00091
    Location:141198
    PAS; PAS domain
    cd19731
    Location:43116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins
  2. XM_017322022.3XP_017177511.1  neuronal PAS domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    smart00091
    Location:141198
    PAS; PAS domain
    cd19731
    Location:43116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins
  3. XM_017322021.3XP_017177510.1  neuronal PAS domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P97459
    UniProtKB/TrEMBL
    A2RSH6
    Related
    ENSMUSP00000147412.2, ENSMUST00000210748.2
    Conserved Domains (3) summary
    smart00091
    Location:141198
    PAS; PAS domain
    pfam08447
    Location:316387
    PAS_3; PAS fold
    cd19731
    Location:43116
    bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins