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    NMT2 N-myristoyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 9397, updated on 11-Apr-2024

    Summary

    Official Symbol
    NMT2provided by HGNC
    Official Full Name
    N-myristoyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:7858
    See related
    Ensembl:ENSG00000152465 MIM:603801; AllianceGenome:HGNC:7858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in fat (RPKM 9.3), testis (RPKM 5.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NMT2 in Genome Data Viewer
    Location:
    10p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15105700..15168693, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15119744..15183186, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15147769..15210692, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15138899-15139470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3091 Neighboring gene RPP38 divergent transcript Neighboring gene ribonuclease P/MRP subunit p38 Neighboring gene uncharacterized LOC105376431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3093 Neighboring gene uncharacterized LOC107984210 Neighboring gene peptidylprolyl isomerase A pseudogene 30 Neighboring gene MPRA-validated peak871 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2169 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene uncharacterized LOC105376434 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:15242369-15243568

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The N-terminal methionine of HIV-1 Nef is myristoylated by N-myristoyltransferase PubMed
    matrix gag HIV-1 Matrix is myristoylated on its N-terminal glycine residue by N-myristoyltransferase, a chemical modification important for membrane targeting of Gag/Matrix, for facilitating Matrix multimerization, and for virus particle formation and budding PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in host cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 2
    Names
    NMT 2
    myristoyl-CoA:protein N-myristoyltransferase 2
    peptide N-myristoyltransferase 2
    protein-lysine myristoyltransferase NMT2
    type II N-myristoyltransferase
    NP_001295224.1
    NP_004799.1
    XP_005252699.1
    XP_006717602.1
    XP_016872438.1
    XP_016872440.1
    XP_024304030.1
    XP_047281975.1
    XP_054223165.1
    XP_054223166.1
    XP_054223167.1
    XP_054223168.1
    XP_054223169.1
    XP_054223170.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308295.2NP_001295224.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 2

      See identical proteins and their annotated locations for NP_001295224.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon which results in the use of an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF043325, AF086423, AK094904, AL590365, DB465189
      Consensus CDS
      CCDS76284.1
      UniProtKB/TrEMBL
      B3KT39, Q5VUC6
      Related
      ENSP00000367392.1, ENST00000378150.1
      Conserved Domains (1) summary
      cl27359
      Location:106473
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    2. NM_004808.3NP_004799.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_004799.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF043325, AL590365
      Consensus CDS
      CCDS7109.1
      UniProtKB/Swiss-Prot
      B0YJ49, O60551, Q53Y38, Q5VUC8, Q9BRB4
      UniProtKB/TrEMBL
      B2RCF3
      Related
      ENSP00000367407.3, ENST00000378165.9
      Conserved Domains (1) summary
      cl27359
      Location:119486
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      15105700..15168693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426019.1XP_047281975.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

    2. XM_005252642.6XP_005252699.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      B2RCF3
      Conserved Domains (2) summary
      pfam01233
      Location:140294
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:310485
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    3. XM_017016949.3XP_016872438.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      B3KT39
    4. XM_006717539.5XP_006717602.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

      UniProtKB/TrEMBL
      B2RCF3
      Conserved Domains (2) summary
      pfam01233
      Location:140256
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:253428
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    5. XM_017016951.3XP_016872440.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X5

      UniProtKB/TrEMBL
      B3KT39
    6. XM_024448262.2XP_024304030.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X6

      UniProtKB/TrEMBL
      B3KT39, B4DHU9
      Conserved Domains (1) summary
      cl27359
      Location:32399
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      15119744..15183186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367192.1XP_054223167.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

    2. XM_054367194.1XP_054223169.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X5

    3. XM_054367195.1XP_054223170.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X6

    4. XM_054367193.1XP_054223168.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

    5. XM_054367190.1XP_054223165.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

    6. XM_054367191.1XP_054223166.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2